Protein family
The protein has not catalytic activity
Protein sequence
Protein function
Publications
Catalytic activity
| PDB | Resolution (Å) | PDB name |
|---|---|---|
| 1YZQ | 1.78 | GppNHp-Bound Rab6 GTPase |
| 2GIL | 1.82 | Structure of the extremely slow GTPase Rab6A in the GTP bound form at 1.8 resolution |
| 3BBP | 3.0 | Rab6-GTP:GCC185 Rab binding domain complex |
| 3CWZ | 3.2 | Structure of RAB6(GTP)-R6IP1 complex |
| 4DKX | 1.9 | Crystal Structure of the Rab 6A'(Q72L) |
| 5LEF | 2.088 | Rab6A:Kif20A complex |
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0019882 | antigen processing and presentation |
| Biological Process | GO:0034498 | early endosome to Golgi transport |
| Biological Process | GO:0006891 | intra-Golgi vesicle-mediated transport |
| Biological Process | GO:0006886 | intracellular protein transport |
| Biological Process | GO:0051179 | localization |
| Biological Process | GO:0072385 | minus-end-directed organelle transport along microtubule |
| Biological Process | GO:0031175 | neuron projection development |
| Biological Process | GO:0018125 | peptidyl-cysteine methylation |
| Biological Process | GO:0034067 | protein localization to Golgi apparatus |
| Biological Process | GO:1903292 | protein localization to Golgi membrane |
| Biological Process | GO:0042147 | retrograde transport, endosome to Golgi |
| Biological Process | GO:0006890 | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum |
| Molecular Function | GO:0005525 | GTP binding |
| Molecular Function | GO:0003924 | GTPase activity |
| Molecular Function | GO:0031489 | myosin V binding |
| Molecular Function | GO:0019904 | protein domain specific binding |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0000139 | Golgi membrane |
| Cellular Component | GO:0002080 | acrosomal membrane |
| Cellular Component | GO:0031410 | cytoplasmic vesicle |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0012505 | endomembrane system |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0070381 | endosome to plasma membrane transport vesicle |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0030667 | secretory granule membrane |
| Cellular Component | GO:0005802 | trans-Golgi network |
| Cellular Component | GO:0032588 | trans-Golgi network membrane |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-1912420 | Pre-NOTCH Processing in Golgi | Leaf | R-HSA-162582 | Signal Transduction |
| R-HSA-6798695 | Neutrophil degranulation | Leaf | R-HSA-168256 | Immune System |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | Leaf | R-HSA-5653656 | Vesicle-mediated transport |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | Leaf | R-HSA-5653656 | Vesicle-mediated transport |
| R-HSA-8854214 | TBC/RABGAPs | Leaf | R-HSA-5653656 | Vesicle-mediated transport |
| R-HSA-8873719 | RAB geranylgeranylation | Leaf | R-HSA-392499 | Metabolism of proteins |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | Leaf | R-HSA-5653656 | Vesicle-mediated transport |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Cytoplasmic vesicle, secretory vesicle, acrosome membrane | ECO:0000250 | |
| Golgi apparatus membrane | ECO:0000269 | PubMed:11071909 |
| Golgi apparatus membrane | ECO:0000269 | PubMed:23091056 |
| Golgi apparatus membrane | ECO:0000269 | PubMed:25962623 |
| HPO ID
|
HPO name |
|---|
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adipose tissue | adipocytes | Low | Approved |
| adrenal gland | glandular cells | High | Approved |
| appendix | glandular cells | Medium | Approved |
| appendix | lymphoid tissue | Low | Approved |
| breast | glandular cells | Low | Approved |
| bronchus | respiratory epithelial cells | High | Approved |
| caudate | glial cells | Low | Approved |
| caudate | neuronal cells | Low | Approved |
| cerebellum | cells in molecular layer | Low | Approved |
| cerebral cortex | endothelial cells | Low | Approved |
| cerebral cortex | glial cells | Low | Approved |
| cerebral cortex | neuronal cells | Medium | Approved |
| cervix | glandular cells | Medium | Approved |
| cervix | squamous epithelial cells | High | Approved |
| colon | glandular cells | Medium | Approved |
| duodenum | glandular cells | High | Approved |
| endometrium 1 | cells in endometrial stroma | High | Approved |
| endometrium 1 | glandular cells | High | Approved |
| endometrium 2 | cells in endometrial stroma | High | Approved |
| endometrium 2 | glandular cells | High | Approved |
| epididymis | glandular cells | Medium | Approved |
| esophagus | squamous epithelial cells | High | Approved |
| fallopian tube | glandular cells | High | Approved |
| gallbladder | glandular cells | Medium | Approved |
| hippocampus | neuronal cells | Low | Approved |
| kidney | cells in glomeruli | Medium | Approved |
| kidney | cells in tubules | Low | Approved |
| liver | hepatocytes | Low | Approved |
| lung | macrophages | Low | Approved |
| lymph node | non-germinal center cells | Low | Approved |
| nasopharynx | respiratory epithelial cells | High | Approved |
| oral mucosa | squamous epithelial cells | Medium | Approved |
| pancreas | exocrine glandular cells | High | Approved |
| parathyroid gland | glandular cells | Low | Approved |
| placenta | decidual cells | High | Approved |
| placenta | trophoblastic cells | High | Approved |
| prostate | glandular cells | High | Approved |
| rectum | glandular cells | High | Approved |
| salivary gland | glandular cells | Medium | Approved |
| seminal vesicle | glandular cells | High | Approved |
| skeletal muscle | myocytes | Low | Approved |
| skin 1 | keratinocytes | Medium | Approved |
| skin 1 | melanocytes | Low | Approved |
| skin 2 | epidermal cells | Medium | Approved |
| small intestine | glandular cells | High | Approved |
| smooth muscle | smooth muscle cells | Low | Approved |
| soft tissue 1 | fibroblasts | Low | Approved |
| soft tissue 1 | peripheral nerve | Low | Approved |
| soft tissue 2 | fibroblasts | Low | Approved |
| soft tissue 2 | peripheral nerve | Low | Approved |
| spleen | cells in red pulp | Medium | Approved |
| stomach 1 | glandular cells | Medium | Approved |
| stomach 2 | glandular cells | Medium | Approved |
| testis | pachytene spermatocytes | High | Approved |
| testis | preleptotene spermatocytes | High | Approved |
| testis | round or early spermatids | High | Approved |
| testis | sertoli cells | Low | Approved |
| testis | spermatogonia cells | High | Approved |
| thyroid gland | glandular cells | Low | Approved |
| tonsil | germinal center cells | Medium | Approved |
| tonsil | non-germinal center cells | Medium | Approved |
| tonsil | squamous epithelial cells | Low | Approved |
| urinary bladder | urothelial cells | High | Approved |
| vagina | squamous epithelial cells | Medium | Approved |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|