Protein family
Protein sequence
Protein function
Catalytic activity
EC number
EC number description
2.5.1.18
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date);
glutathione transferase
PDB | Resolution (Å) | PDB name |
---|---|---|
3GTU | 2.8 | LIGAND-FREE HETERODIMERIC HUMAN GLUTATHIONE S-TRANSFERASE M2-3 (EC 2.5.1.18), MONOCLINIC CRYSTAL FORM |
GO ontology | GO term | GO description |
---|---|---|
Biological Process | GO:0070458 | cellular detoxification of nitrogen compound |
Biological Process | GO:0008065 | establishment of blood-nerve barrier |
Biological Process | GO:0006749 | glutathione metabolic process |
Biological Process | GO:0018916 | nitrobenzene metabolic process |
Biological Process | GO:0043627 | response to estrogen |
Biological Process | GO:0042178 | xenobiotic catabolic process |
Molecular Function | GO:0019899 | enzyme binding |
Molecular Function | GO:0043295 | glutathione binding |
Molecular Function | GO:0004364 | glutathione transferase activity |
Molecular Function | GO:0042802 | identical protein binding |
Molecular Function | GO:0042803 | protein homodimerization activity |
Cellular Component | GO:0005737 | cytoplasm |
Cellular Component | GO:0005829 | cytosol |
Cellular Component | GO:0070062 | extracellular exosome |
Cellular Component | GO:0045171 | intercellular bridge |
Cellular Component | GO:0005634 | nucleus |
Cellular Component | GO:0035686 | sperm fibrous sheath |
InterPro | InterPro name |
---|---|
IPR003081 | Glutathione S-transferase, Mu class |
IPR004045 | Glutathione S-transferase, N-terminal |
IPR004046 | Glutathione S-transferase, C-terminal |
IPR010987 | Glutathione S-transferase, C-terminal-like |
IPR036249 | Thioredoxin-like superfamily |
IPR036282 | Glutathione S-transferase, C-terminal domain superfamily |
IPR040079 | Glutathione transferase family |
Pfam | Pfam name |
---|---|
PF00043 | Glutathione S-transferase, C-terminal domain |
PF02798 | Glutathione S-transferase, N-terminal domain |
Reactome | Reactome Name | Node type | Reactome Root | Reactome Root Name |
---|---|---|---|---|
R-HSA-156590 | Glutathione conjugation | Internal node | R-HSA-1430728 | Metabolism |
HPO ID | HPO name |
---|---|
HP:0000246 | Sinusitis |
HP:0000365 | Hearing impairment |
HP:0000716 | Depression |
HP:0000739 | Anxiety |
HP:0000787 | Nephrolithiasis |
HP:0000938 | Osteopenia |
HP:0000939 | Osteoporosis |
HP:0001392 | Abnormality of the liver |
HP:0001394 | Cirrhosis |
HP:0001508 | Failure to thrive |
HP:0001738 | Exocrine pancreatic insufficiency |
HP:0002020 | Gastroesophageal reflux |
HP:0002024 | Malabsorption |
HP:0002035 | Rectal prolapse |
HP:0002099 | Asthma |
HP:0002105 | Hemoptysis |
HP:0002107 | Pneumothorax |
HP:0002110 | Bronchiectasis |
HP:0002205 | Recurrent respiratory infections |
HP:0002570 | Steatorrhea |
HP:0002724 | Recurrent Aspergillus infections |
HP:0002726 | Recurrent Staphylococcus aureus infections |
HP:0002842 | Recurrent Burkholderia cepacia infections |
HP:0002910 | Elevated hepatic transaminase |
HP:0004401 | Meconium ileus |
HP:0005376 | Recurrent Haemophilus influenzae infections |
HP:0006536 | Airway obstruction |
HP:0012236 | Elevated sweat chloride |
HP:0012873 | Absent vas deferens |
HP:0032261 | Nontuberculous mycobacterial pulmonary infection |
HP:0032342 | Reduced forced expiratory volume in one second |
HP:0045082 | Decreased body mass index |
HP:0100582 | Nasal polyposis |