Protein family
Protein sequence
Protein function
Catalytic activity
EC number
EC number description
2.5.1.18
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date);
glutathione transferase
| PDB | Resolution (Å) | PDB name |
|---|---|---|
| 3GTU | 2.8 | LIGAND-FREE HETERODIMERIC HUMAN GLUTATHIONE S-TRANSFERASE M2-3 (EC 2.5.1.18), MONOCLINIC CRYSTAL FORM |
| GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0070458 | cellular detoxification of nitrogen compound |
| Biological Process | GO:0008065 | establishment of blood-nerve barrier |
| Biological Process | GO:0006749 | glutathione metabolic process |
| Biological Process | GO:0018916 | nitrobenzene metabolic process |
| Biological Process | GO:0043627 | response to estrogen |
| Biological Process | GO:0042178 | xenobiotic catabolic process |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0043295 | glutathione binding |
| Molecular Function | GO:0004364 | glutathione transferase activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0045171 | intercellular bridge |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0035686 | sperm fibrous sheath |
| InterPro
|
InterPro name |
|---|---|
| IPR003081 | Glutathione S-transferase, Mu class |
| IPR004045 | Glutathione S-transferase, N-terminal |
| IPR004046 | Glutathione S-transferase, C-terminal |
| IPR010987 | Glutathione S-transferase, C-terminal-like |
| IPR036249 | Thioredoxin-like superfamily |
| IPR036282 | Glutathione S-transferase, C-terminal domain superfamily |
| IPR040079 | Glutathione transferase family |
| Pfam
|
Pfam name |
|---|---|
| PF00043 | Glutathione S-transferase, C-terminal domain |
| PF02798 | Glutathione S-transferase, N-terminal domain |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-156590 | Glutathione conjugation | Internal node | R-HSA-1430728 | Metabolism |
| HPO ID
|
HPO name |
|---|---|
| HP:0000246 | Sinusitis |
| HP:0000365 | Hearing impairment |
| HP:0000716 | Depression |
| HP:0000739 | Anxiety |
| HP:0000787 | Nephrolithiasis |
| HP:0000938 | Osteopenia |
| HP:0000939 | Osteoporosis |
| HP:0001392 | Abnormality of the liver |
| HP:0001394 | Cirrhosis |
| HP:0001508 | Failure to thrive |
| HP:0001738 | Exocrine pancreatic insufficiency |
| HP:0002020 | Gastroesophageal reflux |
| HP:0002024 | Malabsorption |
| HP:0002035 | Rectal prolapse |
| HP:0002099 | Asthma |
| HP:0002105 | Hemoptysis |
| HP:0002107 | Pneumothorax |
| HP:0002110 | Bronchiectasis |
| HP:0002205 | Recurrent respiratory infections |
| HP:0002570 | Steatorrhea |
| HP:0002724 | Recurrent Aspergillus infections |
| HP:0002726 | Recurrent Staphylococcus aureus infections |
| HP:0002842 | Recurrent Burkholderia cepacia infections |
| HP:0002910 | Elevated hepatic transaminase |
| HP:0004401 | Meconium ileus |
| HP:0005376 | Recurrent Haemophilus influenzae infections |
| HP:0006536 | Airway obstruction |
| HP:0012236 | Elevated sweat chloride |
| HP:0012873 | Absent vas deferens |
| HP:0032261 | Nontuberculous mycobacterial pulmonary infection |
| HP:0032342 | Reduced forced expiratory volume in one second |
| HP:0045082 | Decreased body mass index |
| HP:0100582 | Nasal polyposis |