MultifacetedProtDB - Bologna Biocomputing Group

EC number	EC number description
4.2.1.3	Lyases; Carbon-oxygen lyases; Hydro-lyases; aconitate hydratase

PDB	Resolution (Å)	PDB name
2B3X	2.54	Structure of an orthorhombic crystal form of human cytosolic aconitase (IRP1)
2B3Y	1.85	Structure of a monoclinic crystal form of human cytosolic aconitase (IRP1)

GO ontology	GO term	GO description
Biological Process	GO:0006101	citrate metabolic process
Biological Process	GO:0050892	intestinal absorption
Biological Process	GO:0006879	intracellular iron ion homeostasis
Biological Process	GO:0009791	post-embryonic development
Biological Process	GO:0006417	regulation of translation
Biological Process	GO:0010040	response to iron(II) ion
Biological Process	GO:0006099	tricarboxylic acid cycle
Molecular Function	GO:0051538	3 iron, 4 sulfur cluster binding
Molecular Function	GO:0051539	4 iron, 4 sulfur cluster binding
Molecular Function	GO:0003723	RNA binding
Molecular Function	GO:0003994	aconitate hydratase activity
Molecular Function	GO:0047780	citrate dehydratase activity
Molecular Function	GO:0030350	iron-responsive element binding
Molecular Function	GO:0046872	metal ion binding
Cellular Component	GO:0005794	Golgi apparatus
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005783	endoplasmic reticulum
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0005739	mitochondrion

InterPro	InterPro name
IPR000573	Aconitase A/isopropylmalate dehydratase small subunit, swivel domain
IPR001030	Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain
IPR006249	Aconitase/Iron-responsive element-binding protein 2
IPR015928	Aconitase/3-isopropylmalate dehydratase, swivel
IPR015931	Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3
IPR018136	Aconitase family, 4Fe-4S cluster binding site
IPR036008	Aconitase, iron-sulfur domain
IPR044137	Aconitase A, swivel domain

Pfam	Pfam name
PF00330	Aconitase family (aconitate hydratase)
PF00694	Aconitase C-terminal domain

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-917937	Iron uptake and transport	Internal node	R-HSA-382551	Transport of small molecules

Location	ECO term	Pubmed
Cytoplasm, cytosol	ECO:0000269	PubMed:1281544

Tissue	Cell type	Expression level	Reliability
adipose tissue	adipocytes	High	Enhanced
adrenal gland	glandular cells	Medium	Enhanced
appendix	glandular cells	Medium	Enhanced
appendix	lymphoid tissue	Low	Enhanced
caudate	glial cells	Low	Enhanced
caudate	neuronal cells	Medium	Enhanced
cerebral cortex	glial cells	Low	Enhanced
cerebral cortex	neuronal cells	Low	Enhanced
colon	glandular cells	Medium	Enhanced
duodenum	glandular cells	High	Enhanced
endometrium 1	glandular cells	Low	Enhanced
epididymis	glandular cells	Medium	Enhanced
gallbladder	glandular cells	Medium	Enhanced
heart muscle	cardiomyocytes	Medium	Enhanced
hippocampus	glial cells	Low	Enhanced
hippocampus	neuronal cells	Medium	Enhanced
kidney	collecting ducts	Low	Enhanced
kidney	distal tubules	Low	Enhanced
kidney	proximal tubules (cell body)	High	Enhanced
liver	cholangiocytes	Low	Enhanced
liver	hepatocytes	Medium	Enhanced
lung	macrophages	Medium	Enhanced
ovary	follicle cells	Medium	Enhanced
pancreas	exocrine glandular cells	Medium	Enhanced
pancreas	pancreatic endocrine cells	Low	Enhanced
parathyroid gland	glandular cells	Low	Enhanced
placenta	trophoblastic cells	Medium	Enhanced
prostate	glandular cells	Medium	Enhanced
rectum	glandular cells	Low	Enhanced
skeletal muscle	myocytes	Low	Enhanced
small intestine	glandular cells	High	Enhanced
stomach 1	glandular cells	High	Enhanced
stomach 2	glandular cells	High	Enhanced
testis	Leydig cells	High	Enhanced
testis	sertoli cells	High	Enhanced
thyroid gland	glandular cells	Medium	Enhanced
tonsil	germinal center cells	Low	Enhanced
urinary bladder	urothelial cells	Medium	Enhanced