MultifacetedProtDB - Bologna Biocomputing Group

EC number	EC number description
2.3.2.-	Transferases; Acyltransferases; Aminoacyltransferases;
3.4.19.12	Hydrolases; Acting on peptide bonds (peptidases); Omega peptidases; ubiquitinyl hydrolase 1

Structure

PDB	Resolution (Å)	PDB name
2EQE		Solution structure of the fourth A20-type zinc finger domain from human tumor necrosis factor, alpha-induced protein3
2EQF		Solution structure of the 7th A20-type zinc finger domain from human tumor necrosis factor, alpha-induced protein3
2EQG		Solution structure of the first A20-type zinc finger domain from human tumor necrosis factor, alpha-induced protein3
2VFJ	3.2	Structure of the A20 Ovarian Tumour (OTU) domain
3DKB	2.5	Crystal Structure of A20, 2.5 angstrom
3OJ3	2.5	Crystal structure of the A20 ZnF4 and ubiquitin complex
3OJ4	3.4	Crystal structure of the A20 ZnF4, ubiquitin and UbcH5A complex
3VUW	1.95	Crystal structure of A20 ZF7 in complex with linear ubiquitin, form I
3VUX	1.699	Crystal structure of A20 ZF7 in complex with linear ubiquitin, form II
3VUY	1.981	Crystal structure of A20 ZF7 in complex with linear tetraubiquitin
3ZJD	1.87	A20 OTU domain in reduced, active state at 1.87 A resolution
3ZJE	1.84	A20 OTU domain in reversibly oxidised (SOH) state
3ZJF	2.2	A20 OTU domain with irreversibly oxidised Cys103 from 270 min H2O2 soak.
3ZJG	1.92	A20 OTU domain with irreversibly oxidised Cys103 from 60 min H2O2 soak.
5LRX	2.85	Structure of A20 OTU domain bound to ubiquitin
5V3B	3.0	Human A20 OTU domain (WT) with acetamidylated C103
5V3P	2.5	Human A20 OTU domain (I325N) with acetamidylated C103

GO term

GO ontology	GO term	GO description
Biological Process	GO:0001922	B-1 B cell homeostasis
Biological Process	GO:0006915	apoptotic process
Biological Process	GO:0016477	cell migration
Biological Process	GO:0070301	cellular response to hydrogen peroxide
Biological Process	GO:0071222	cellular response to lipopolysaccharide
Biological Process	GO:0007010	cytoskeleton organization
Biological Process	GO:0072666	establishment of protein localization to vacuole
Biological Process	GO:0006954	inflammatory response
Biological Process	GO:0050869	negative regulation of B cell activation
Biological Process	GO:2000349	negative regulation of CD40 signaling pathway
Biological Process	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity
Biological Process	GO:0045779	negative regulation of bone resorption
Biological Process	GO:0002677	negative regulation of chronic inflammatory response
Biological Process	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity
Biological Process	GO:2000352	negative regulation of endothelial cell apoptotic process
Biological Process	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
Biological Process	GO:0050728	negative regulation of inflammatory response
Biological Process	GO:0045824	negative regulation of innate immune response
Biological Process	GO:0032691	negative regulation of interleukin-1 beta production
Biological Process	GO:0032703	negative regulation of interleukin-2 production
Biological Process	GO:0032715	negative regulation of interleukin-6 production
Biological Process	GO:0070429	negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
Biological Process	GO:0070433	negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
Biological Process	GO:0090291	negative regulation of osteoclast proliferation
Biological Process	GO:0031397	negative regulation of protein ubiquitination
Biological Process	GO:0048662	negative regulation of smooth muscle cell proliferation
Biological Process	GO:0034136	negative regulation of toll-like receptor 2 signaling pathway
Biological Process	GO:0034140	negative regulation of toll-like receptor 3 signaling pathway
Biological Process	GO:0034144	negative regulation of toll-like receptor 4 signaling pathway
Biological Process	GO:0034148	negative regulation of toll-like receptor 5 signaling pathway
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production
Biological Process	GO:0070423	nucleotide-binding oligomerization domain containing signaling pathway
Biological Process	GO:0030177	positive regulation of Wnt signaling pathway
Biological Process	GO:2000347	positive regulation of hepatocyte proliferation
Biological Process	GO:0045732	positive regulation of protein catabolic process
Biological Process	GO:0035871	protein K11-linked deubiquitination
Biological Process	GO:0035523	protein K29-linked deubiquitination
Biological Process	GO:1990168	protein K33-linked deubiquitination
Biological Process	GO:0071108	protein K48-linked deubiquitination
Biological Process	GO:0070936	protein K48-linked ubiquitination
Biological Process	GO:0070536	protein K63-linked deubiquitination
Biological Process	GO:0016579	protein deubiquitination
Biological Process	GO:0071947	protein deubiquitination involved in ubiquitin-dependent protein catabolic process
Biological Process	GO:0050691	regulation of defense response to virus by host
Biological Process	GO:0002634	regulation of germinal center formation
Biological Process	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway
Biological Process	GO:0061043	regulation of vascular wound healing
Biological Process	GO:0002237	response to molecule of bacterial origin
Biological Process	GO:0032495	response to muramyl dipeptide
Biological Process	GO:0072573	tolerance induction to lipopolysaccharide
Molecular Function	GO:0003677	DNA binding
Molecular Function	GO:0061578	K63-linked deubiquitinase activity
Molecular Function	GO:0070530	K63-linked polyubiquitin modification-dependent protein binding
Molecular Function	GO:0004843	cysteine-type deubiquitinase activity
Molecular Function	GO:0042802	identical protein binding
Molecular Function	GO:0019900	kinase binding
Molecular Function	GO:0002020	protease binding
Molecular Function	GO:0043621	protein self-association
Molecular Function	GO:0043130	ubiquitin binding
Molecular Function	GO:0004842	ubiquitin-protein transferase activity
Molecular Function	GO:0008270	zinc ion binding
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0005764	lysosome
Cellular Component	GO:0005634	nucleus

InterPro / Pfam

InterPro	InterPro name
IPR002653	Zinc finger, A20-type
IPR003323	OTU domain

Pfam	Pfam name
PF01754	A20-like zinc finger
PF02338	OTU-like cysteine protease

Reactome

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-168638	NOD1/2 Signaling Pathway	Leaf	R-HSA-168256	Immune System
R-HSA-5357786	TNFR1-induced proapoptotic signaling	Leaf	R-HSA-162582	Signal Transduction
R-HSA-5357905	Regulation of TNFR1 signaling	Leaf	R-HSA-162582	Signal Transduction
R-HSA-5357956	TNFR1-induced NFkappaB signaling pathway	Leaf	R-HSA-162582	Signal Transduction
R-HSA-5689896	Ovarian tumor domain proteases	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-936440	Negative regulators of DDX58/IFIH1 signaling	Leaf	R-HSA-168256	Immune System

Subcellular location

Interactor | Variant | Drug

Phenotype

HPO ID	HPO name
HP:0000006	Autosomal dominant inheritance
HP:0000155	Oral ulcer
HP:0000988	Skin rash
HP:0001873	Thrombocytopenia
HP:0001878	Hemolytic anemia
HP:0001888	Lymphopenia
HP:0001954	Recurrent fever
HP:0002072	Chorea
HP:0002583	Colitis
HP:0003249	Genital ulcers
HP:0003493	Antinuclear antibody positivity
HP:0003593	Infantile onset
HP:0003621	Juvenile onset
HP:0005764	Polyarticular arthritis
HP:0011462	Young adult onset
HP:0011463	Childhood onset
HP:0012122	Anterior uveitis
HP:0025343	Lupus anticoagulant
HP:0032024	Ileal ulcer

Tissue and cell type

Tissue	Cell type	Expression level	Reliability
adipose tissue	adipocytes	Medium	Approved
adrenal gland	glandular cells	Medium	Approved
appendix	glandular cells	Low	Approved
appendix	lymphoid tissue	Medium	Approved
bone marrow	hematopoietic cells	Medium	Approved
breast	adipocytes	Low	Approved
breast	glandular cells	Low	Approved
breast	myoepithelial cells	Low	Approved
bronchus	respiratory epithelial cells	Medium	Approved
caudate	neuronal cells	Medium	Approved
cerebellum	Purkinje cells	Medium	Approved
cerebellum	cells in molecular layer	Low	Approved
cerebral cortex	endothelial cells	Low	Approved
cerebral cortex	neuronal cells	Low	Approved
cerebral cortex	neuropil	Medium	Approved
cervix	glandular cells	Low	Approved
cervix	squamous epithelial cells	Low	Approved
colon	endothelial cells	Medium	Approved
colon	glandular cells	Low	Approved
colon	peripheral nerve/ganglion	Medium	Approved
duodenum	glandular cells	Low	Approved
endometrium 1	cells in endometrial stroma	Medium	Approved
endometrium 1	glandular cells	Medium	Approved
endometrium 2	cells in endometrial stroma	Low	Approved
endometrium 2	glandular cells	Medium	Approved
epididymis	glandular cells	Medium	Approved
esophagus	squamous epithelial cells	Low	Approved
fallopian tube	glandular cells	Medium	Approved
gallbladder	glandular cells	Low	Approved
heart muscle	cardiomyocytes	Low	Approved
hippocampus	neuronal cells	Medium	Approved
kidney	cells in glomeruli	Medium	Approved
kidney	cells in tubules	Low	Approved
liver	cholangiocytes	Low	Approved
liver	hepatocytes	Low	Approved
lung	alveolar cells	Low	Approved
lung	macrophages	High	Approved
lymph node	germinal center cells	Low	Approved
nasopharynx	respiratory epithelial cells	Medium	Approved
oral mucosa	squamous epithelial cells	Low	Approved
ovary	follicle cells	Low	Approved
ovary	ovarian stroma cells	High	Approved
pancreas	exocrine glandular cells	Low	Approved
pancreas	pancreatic endocrine cells	Low	Approved
parathyroid gland	glandular cells	Medium	Approved
placenta	decidual cells	Medium	Approved
placenta	trophoblastic cells	Low	Approved
prostate	glandular cells	Low	Approved
rectum	glandular cells	Low	Approved
salivary gland	glandular cells	Low	Approved
seminal vesicle	glandular cells	Low	Approved
skeletal muscle	myocytes	Medium	Approved
skin 1	Langerhans	Low	Approved
skin 1	fibroblasts	Medium	Approved
skin 1	melanocytes	Medium	Approved
skin 2	epidermal cells	Low	Approved
small intestine	glandular cells	Low	Approved
smooth muscle	smooth muscle cells	Low	Approved
soft tissue 1	chondrocytes	Low	Approved
soft tissue 1	fibroblasts	Medium	Approved
soft tissue 2	fibroblasts	Medium	Approved
stomach 1	glandular cells	Low	Approved
stomach 2	glandular cells	Low	Approved
testis	Leydig cells	Medium	Approved
testis	cells in seminiferous ducts	Medium	Approved
thyroid gland	glandular cells	Medium	Approved
urinary bladder	urothelial cells	Medium	Approved
vagina	squamous epithelial cells	Low	Approved

Location	ECO term	Pubmed
Cytoplasm
Lysosome
Nucleus

Summary of P21580

Gene: TNFAIP3, OTUD7C
Protein: Tumor necrosis factor alpha-induced protein 3

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of P21580

Gene: TNFAIP3, OTUD7C Protein: Tumor necrosis factor alpha-induced protein 3

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: TNFAIP3, OTUD7C
Protein: Tumor necrosis factor alpha-induced protein 3