Protein family
Protein sequence
Protein function
Catalytic activity
EC number
EC number description
2.3.1.48
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups;
histone acetyltransferase
2.7.11.1
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases;
non-specific serine/threonine protein kinase
PDB | Resolution (Å) | PDB name |
---|---|---|
1EQF | 2.1 | CRYSTAL STRUCTURE OF THE DOUBLE BROMODOMAIN MODULE FROM HUMAN TAFII250 |
3AAD | 3.3 | Structure of the histone chaperone CIA/ASF1-double bromodomain complex linking histone modifications and site-specific histone eviction |
3UV4 | 1.89 | Crystal Structure of the second bromodomain of human Transcription initiation factor TFIID subunit 1 (TAF1) |
3UV5 | 2.03 | Crystal Structure of the tandem bromodomains of human Transcription initiation factor TFIID subunit 1 (TAF1) |
4RGW | 2.301 | Crystal Structure of a TAF1-TAF7 Complex in Human Transcription Factor IID |
4YYM | 1.5 | Crystal structure of TAF1 BD2 Bromodomain bound to a butyryllysine peptide |
4YYN | 1.85 | Crystal structure of TAF1 BD2 Bromodomain bound to a crotonyllysine peptide |
5FUR | 8.5 | Structure of human TFIID-IIA bound to core promoter DNA |
5I1Q | 1.5 | Second bromodomain of TAF1 bound to a pyrrolopyridone compound |
5I29 | 1.21 | TAF1(2) bound to a pyrrolopyridone compound |
5MG2 | 1.75 | Crystal structure of the second bromodomain of human TAF1 in complex with BAY-299 chemical probe |
6BQD | 2.136 | TAF1-BD2 bromodomain in complex with (E)-3-(6-(but-2-en-1-yl)-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)-N,N-dimethylbenzamide |
6FIC | 2.18 | Bivalent Inhibitor UNC4512 Bound to the TAF1 Bromodomain Tandem |
6MZD | 9.8 | Human TFIID Lobe A canonical |
6MZL | 23.0 | Human TFIID canonical state |
6MZM | 7.5 | Human TFIID bound to promoter DNA and TFIIA |
6P38 | 2.8 | Crystal Structure Analysis of TAF1 Bromodomain |
6P39 | 2.941 | Crystal Structure Analysis of TAF1 Bromodomain |
6P3A | 2.99 | Crystal Structure Analysis of TAF1 Bromodomain |
7EDX | 4.5 | p53-bound TFIID-based core PIC on HDM2 promoter |
7EG7 | 6.2 | TFIID-based core PIC on SCP promoter |
7EG8 | 7.4 | TFIID-based core PIC on PUMA promoter |
7EG9 | 3.7 | TFIID-based intermediate PIC on SCP promoter |
7EGA | 4.1 | TFIID-based intermediate PIC on PUMA promoter |
7EGB | 3.3 | TFIID-based holo PIC on SCP promoter |
7EGC | 3.9 | p53-bound TFIID-based holo PIC on HDM2 promoter |
7EGD | 6.75 | SCP promoter-bound TFIID-TFIIA in initial TBP-loading state |
7EGE | 9.0 | TFIID in canonical conformation |
7EGH | 3.04 | TFIID lobe C subcomplex |
7EGI | 9.82 | TFIID in rearranged conformation |
7EGJ | 8.64 | SCP promoter-bound TFIID-TFIIA in post TBP-loading state |
7ENA | 4.07 | TFIID-based PIC-Mediator holo-complex in pre-assembled state (pre-hPIC-MED) |
7ENC | 4.13 | TFIID-based PIC-Mediator holo-complex in fully-assembled state (hPIC-MED) |
7JJG | 1.6 | Crystal structure of the second bromodomain (BD2) of human TAF1 bound to ATR kinase inhibitor AZ20 |
7JJH | 2.1 | Crystal structure of the unliganded tandem bromodomain (BD1, BD2) of human TAF1 |
7JSP | 1.7 | Crystal structure of the second bromodomain (BD2) of human TAF1 bound to ATR kinase inhibitor AZD6738 |
7JTC | 2.05 | Crystal structure of the second bromodomain (BD2) of human TAF1 bound to ZS1-322 |
7K03 | 1.6 | Crystal structure of the tandem bromodomain (BD1 and BD2) of human TAF1 bound to ATR kinase inhibitor AZD6738 |
7K0D | 2.2 | Crystal structure of the tandem bromodomain (BD1, BD2) of human TAF1 bound to mTORC1/2 inhibitor AZD3147 |
7K0U | 2.52 | Crystal structure of the second bromodomain (BD2) of human TAF1 bound to PLK1 kinase inhibitor BI2536 |
7K1P | 2.45 | Crystal structure of the second bromodomain (BD2) of human TAF1 bound to bromosporine |
7K27 | 1.5 | Crystal structure of the tandem bromodomain (BD1, BD2) of human TAF1 bound to ATR inhibitor AZ20 |
7K3O | 1.7 | Crystal structure of the unliganded second bromodomain (BD2) of human TAF1 |
7K42 | 1.7 | Crystal structure of the second bromodomain (BD2) of human TAF1 bound to dioxane |
7K6F | 1.86 | Crystal structure of the tandem bromodomain (BD1, BD2) of human TAF1 in complex with MES (2-(N-morpholino)ethanesulfonic acid) |
7L6X | 2.75 | Crystal structure of the tandem bromodomain (BD1, BD2) of human TAF1 bound to GNE-371 |
7LB0 | 2.33 | Crystal structure of the tandem bromodomain (BD1, BD2) of human TAF1 bound to ZS1-295 |
7LB1 | 1.35 | Crystal structure of the tandem bromodomain (BD1, BD2) of human TAF1 bound to ZS1-585 |
7LB2 | 1.7 | Crystal structure of the tandem bromodomain (BD1, BD2) of human TAF1 bound to ZS1-589 |
7LB3 | 1.9 | Crystal structure of the second bromodomain (BD2) of human TAF1 bound to ZS1-580 |
7N42 | 1.9 | Crystal structure of the tandem bromodomain of human TAF1 (TAF1-T) bound to ZS1-681 |
7P4S | 2.17 | BROMODOMAIN OF HUMAN TAF1 (2) WITH naphthyridinone compound |
7T2I | 1.89 | Crystal structure of the tandem bromodomain (BD1, BD2) of human TAF1 bound to ZS1-588 |
7T36 | 1.65 | Crystal structure of the tandem bromodomain (BD1 and BD2) of human TAF1 bound to ZS1-322 |
8GXQ | 5.04 | PIC-Mediator in complex with +1 nucleosome (T40N) in MH-binding state |
8GXS | 4.16 | PIC-Mediator in complex with +1 nucleosome (T40N) in H-binding state |
GO ontology | GO term | GO description |
---|---|---|
Biological Process | GO:0006974 | DNA damage response |
Biological Process | GO:0051123 | RNA polymerase II preinitiation complex assembly |
Biological Process | GO:0007049 | cell cycle |
Biological Process | GO:0071318 | cellular response to ATP |
Biological Process | GO:0034644 | cellular response to UV |
Biological Process | GO:0042789 | mRNA transcription by RNA polymerase II |
Biological Process | GO:0030901 | midbrain development |
Biological Process | GO:0043433 | negative regulation of DNA-binding transcription factor activity |
Biological Process | GO:1903026 | negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding |
Biological Process | GO:0010629 | negative regulation of gene expression |
Biological Process | GO:1905524 | negative regulation of protein autoubiquitination |
Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
Biological Process | GO:2000059 | negative regulation of ubiquitin-dependent protein catabolic process |
Biological Process | GO:0018105 | peptidyl-serine phosphorylation |
Biological Process | GO:0018107 | peptidyl-threonine phosphorylation |
Biological Process | GO:2000825 | positive regulation of androgen receptor activity |
Biological Process | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
Biological Process | GO:0032092 | positive regulation of protein binding |
Biological Process | GO:0060261 | positive regulation of transcription initiation by RNA polymerase II |
Biological Process | GO:0046777 | protein autophosphorylation |
Biological Process | GO:0006468 | protein phosphorylation |
Biological Process | GO:0000209 | protein polyubiquitination |
Biological Process | GO:0050821 | protein stabilization |
Biological Process | GO:1902806 | regulation of cell cycle G1/S phase transition |
Biological Process | GO:1901796 | regulation of signal transduction by p53 class mediator |
Biological Process | GO:0006366 | transcription by RNA polymerase II |
Biological Process | GO:0036369 | transcription factor catabolic process |
Biological Process | GO:0006361 | transcription initiation at RNA polymerase I promoter |
Biological Process | GO:0006367 | transcription initiation at RNA polymerase II promoter |
Biological Process | GO:0006511 | ubiquitin-dependent protein catabolic process |
Molecular Function | GO:0005524 | ATP binding |
Molecular Function | GO:0001181 | RNA polymerase I general transcription initiation factor activity |
Molecular Function | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding |
Molecular Function | GO:0016251 | RNA polymerase II general transcription initiation factor activity |
Molecular Function | GO:0001091 | RNA polymerase II general transcription initiation factor binding |
Molecular Function | GO:0061629 | RNA polymerase II-specific DNA-binding transcription factor binding |
Molecular Function | GO:0017025 | TBP-class protein binding |
Molecular Function | GO:0004402 | histone acetyltransferase activity |
Molecular Function | GO:0016301 | kinase activity |
Molecular Function | GO:0070577 | lysine-acetylated histone binding |
Molecular Function | GO:0016922 | nuclear receptor binding |
Molecular Function | GO:0002039 | p53 binding |
Molecular Function | GO:0046982 | protein heterodimerization activity |
Molecular Function | GO:0004672 | protein kinase activity |
Molecular Function | GO:0106310 | protein serine kinase activity |
Molecular Function | GO:0004674 | protein serine/threonine kinase activity |
Molecular Function | GO:0043565 | sequence-specific DNA binding |
Molecular Function | GO:0140416 | transcription regulator inhibitor activity |
Molecular Function | GO:0061631 | ubiquitin conjugating enzyme activity |
Cellular Component | GO:0071339 | MLL1 complex |
Cellular Component | GO:0000785 | chromatin |
Cellular Component | GO:0005654 | nucleoplasm |
Cellular Component | GO:0005634 | nucleus |
Cellular Component | GO:0005669 | transcription factor TFIID complex |
Cellular Component | GO:0005667 | transcription regulator complex |
InterPro | InterPro name |
---|---|
IPR001487 | Bromodomain |
IPR009067 | TAFII-230 TBP-binding |
IPR011177 | Transcription initiation factor TFIID subunit 1, animal |
IPR018359 | Bromodomain, conserved site |
IPR022591 | Transcription initiation factor TFIID subunit 1, histone acetyltransferase domain |
IPR036427 | Bromodomain-like superfamily |
IPR036741 | TAFII-230 TBP-binding domain superfamily |
IPR040240 | Transcription initiation factor TFIID subunit 1 |
IPR041670 | Zinc knuckle |
Pfam | Pfam name |
---|---|
PF00439 | Bromodomain |
PF09247 | TATA box-binding protein binding |
PF12157 | Protein of unknown function (DUF3591) |
PF15288 | Zinc knuckle |
Reactome | Reactome Name | Node type | Reactome Root | Reactome Root Name |
---|---|---|---|---|
R-HSA-167161 | HIV Transcription Initiation | Leaf | R-HSA-1643685 | Disease |
R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | Leaf | R-HSA-1643685 | Disease |
R-HSA-167172 | Transcription of the HIV genome | Internal node | R-HSA-1643685 | Disease |
R-HSA-674695 | RNA Polymerase II Pre-transcription Events | Leaf | R-HSA-74160 | Gene expression (Transcription) |
R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | Leaf | R-HSA-74160 | Gene expression (Transcription) |
R-HSA-73776 | RNA Polymerase II Promoter Escape | Leaf | R-HSA-74160 | Gene expression (Transcription) |
R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | Leaf | R-HSA-74160 | Gene expression (Transcription) |
R-HSA-75953 | RNA Polymerase II Transcription Initiation | Leaf | R-HSA-74160 | Gene expression (Transcription) |
R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | Internal node | R-HSA-74160 | Gene expression (Transcription) |
Location | ECO term | Pubmed |
---|---|---|
Nucleus | ECO:0000269 | PubMed:2038334 |
Nucleus | ECO:0000269 | PubMed:25593309 |
Nucleus | ECO:0000269 | PubMed:27007846 |
HPO ID | HPO name |
---|---|
HP:0000218 | High palate |
HP:0000219 | Thin upper lip vermilion |
HP:0000252 | Microcephaly |
HP:0000276 | Long face |
HP:0000286 | Epicanthus |
HP:0000307 | Pointed chin |
HP:0000308 | Microretrognathia |
HP:0000316 | Hypertelorism |
HP:0000336 | Prominent supraorbital ridges |
HP:0000343 | Long philtrum |
HP:0000347 | Micrognathia |
HP:0000365 | Hearing impairment |
HP:0000369 | Low-set ears |
HP:0000389 | Chronic otitis media |
HP:0000391 | Thickened helices |
HP:0000400 | Macrotia |
HP:0000411 | Protruding ear |
HP:0000414 | Bulbous nose |
HP:0000437 | Depressed nasal tip |
HP:0000455 | Broad nasal tip |
HP:0000463 | Anteverted nares |
HP:0000470 | Short neck |
HP:0000486 | Strabismus |
HP:0000490 | Deeply set eye |
HP:0000494 | Downslanted palpebral fissures |
HP:0000496 | Abnormality of eye movement |
HP:0000520 | Proptosis |
HP:0000527 | Long eyelashes |
HP:0000545 | Myopia |
HP:0000574 | Thick eyebrow |
HP:0000579 | Nasolacrimal duct obstruction |
HP:0000639 | Nystagmus |
HP:0000643 | Blepharospasm |
HP:0000664 | Synophrys |
HP:0000729 | Autistic behavior |
HP:0000739 | Anxiety |
HP:0000750 | Delayed speech and language development |
HP:0000767 | Pectus excavatum |
HP:0000938 | Osteopenia |
HP:0000960 | Sacral dimple |
HP:0000964 | Eczema |
HP:0001007 | Hirsutism |
HP:0001057 | Aplasia cutis congenita |
HP:0001249 | Intellectual disability |
HP:0001250 | Seizure |
HP:0001251 | Ataxia |
HP:0001257 | Spasticity |
HP:0001263 | Global developmental delay |
HP:0001264 | Spastic diplegia |
HP:0001272 | Cerebellar atrophy |
HP:0001288 | Gait disturbance |
HP:0001290 | Generalized hypotonia |
HP:0001304 | Torsion dystonia |
HP:0001315 | Reduced tendon reflexes |
HP:0001320 | Cerebellar vermis hypoplasia |
HP:0001321 | Cerebellar hypoplasia |
HP:0001332 | Dystonia |
HP:0001336 | Myoclonus |
HP:0001337 | Tremor |
HP:0001382 | Joint hypermobility |
HP:0001385 | Hip dysplasia |
HP:0001419 | X-linked recessive inheritance |
HP:0001511 | Intrauterine growth retardation |
HP:0001513 | Obesity |
HP:0001999 | Abnormal facial shape |
HP:0002019 | Constipation |
HP:0002020 | Gastroesophageal reflux |
HP:0002067 | Bradykinesia |
HP:0002072 | Chorea |
HP:0002079 | Hypoplasia of the corpus callosum |
HP:0002119 | Ventriculomegaly |
HP:0002141 | Gait imbalance |
HP:0002172 | Postural instability |
HP:0002194 | Delayed gross motor development |
HP:0002322 | Resting tremor |
HP:0002342 | Intellectual disability, moderate |
HP:0002355 | Difficulty walking |
HP:0002359 | Frequent falls |
HP:0002362 | Shuffling gait |
HP:0002378 | Hand tremor |
HP:0002395 | Lower limb hyperreflexia |
HP:0002451 | Limb dystonia |
HP:0002548 | Parkinsonism with favorable response to dopaminergic medication |
HP:0002650 | Scoliosis |
HP:0002705 | High, narrow palate |
HP:0002808 | Kyphosis |
HP:0003577 | Congenital onset |
HP:0003581 | Adult onset |
HP:0004373 | Focal dystonia |
HP:0004696 | Talipes cavus equinovarus |
HP:0005280 | Depressed nasal bridge |
HP:0005469 | Flat occiput |
HP:0006511 | Laryngeal stridor |
HP:0006863 | Severe expressive language delay |
HP:0006979 | Sleep-wake cycle disturbance |
HP:0007018 | Attention deficit hyperactivity disorder |
HP:0007158 | Progressive extrapyramidal muscular rigidity |
HP:0007375 | Abnormal septum pellucidum morphology |
HP:0008070 | Sparse hair |
HP:0008468 | Abnormal sacral segmentation |
HP:0008472 | Prominent protruding coccyx |
HP:0008897 | Postnatal growth retardation |
HP:0009894 | Thickened ears |
HP:0010808 | Protruding tongue |
HP:0011220 | Prominent forehead |
HP:0011410 | Caesarian section |
HP:0011822 | Broad chin |
HP:0011927 | Short digit |
HP:0011951 | Aspiration pneumonia |
HP:0012032 | Lipoma |
HP:0031162 | Impaired oropharyngeal swallow response |
HP:0040016 | Prominent coccyx |
HP:0100797 | Toenail dysplasia |
HP:0200136 | Oral-pharyngeal dysphagia |
Disease name | MONDO ID | ICD10 | ICD10 chapter | OMIM | Orphanet |
---|---|---|---|---|---|
intellectual disability, x-linked, syndromic 33 | MONDO:0010500 | F70 | chapter5, Mental and behavioural disorders | OMIM:300966 | |
x-linked dystonia-parkinsonism | MONDO:0010747 | G24 | chapter6, Diseases of the nervous system | OMIM:314250 | Orphanet:53351 |
x-linked intellectual disability-global development delay-facial dysmorphism-sacral caudal remnant syndrome | MONDO:0018823 | Q87 | chapter17, Congenital malformations, deformations and chromosomal abnormalities | Orphanet:480907 |