Protein family
The protein has not catalytic activity
Protein sequence
Protein function
Publications
Catalytic activity
| PDB | Resolution (Å) | PDB name |
|---|---|---|
| 5AJ0 | 3.5 | Cryo electron microscopy of actively translating human polysomes (POST state). |
| 5FLX | 3.9 | Mammalian 40S HCV-IRES complex |
| 6OLG | 3.4 | Human ribosome nascent chain complex stalled by a drug-like small molecule (CDH1_RNC with PP tRNA) |
| 6OLZ | 3.9 | Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like molecule with PP tRNA |
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0006412 | translation |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0019843 | rRNA binding |
| Molecular Function | GO:0003735 | structural constituent of ribosome |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0022627 | cytosolic small ribosomal subunit |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005844 | polysome |
| InterPro
|
InterPro name |
|---|---|
| IPR000876 | Ribosomal protein S4e |
| IPR002942 | RNA-binding S4 domain |
| IPR005824 | KOW |
| IPR013843 | Ribosomal protein S4e, N-terminal |
| IPR013845 | Ribosomal protein S4e, central region |
| IPR014722 | Ribosomal protein L2, domain 2 |
| IPR018199 | Ribosomal protein S4e, N-terminal, conserved site |
| IPR032277 | 40S ribosomal protein S4, C-terminal domain |
| IPR036986 | RNA-binding S4 domain superfamily |
| IPR038237 | Ribosomal protein S4e, central domain superfamily |
| IPR041982 | Ribosomal protein S4, KOW domain |
| Pfam
|
Pfam name |
|---|---|
| PF00467 | KOW motif |
| PF00900 | Ribosomal family S4e |
| PF08071 | RS4NT (NUC023) domain |
| PF16121 | 40S ribosomal protein S4 C-terminus |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | Leaf | R-HSA-392499 | Metabolism of proteins |
| R-HSA-156902 | Peptide chain elongation | Leaf | R-HSA-392499 | Metabolism of proteins |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | Leaf | R-HSA-392499 | Metabolism of proteins |
| R-HSA-192823 | Viral mRNA Translation | Leaf | R-HSA-1643685 | Disease |
| R-HSA-2408557 | Selenocysteine synthesis | Leaf | R-HSA-1430728 | Metabolism |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | Leaf | R-HSA-8953854 | Metabolism of RNA |
| R-HSA-72649 | Translation initiation complex formation | Leaf | R-HSA-392499 | Metabolism of proteins |
| R-HSA-72689 | Formation of a pool of free 40S subunits | Leaf | R-HSA-392499 | Metabolism of proteins |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | Leaf | R-HSA-392499 | Metabolism of proteins |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | Leaf | R-HSA-392499 | Metabolism of proteins |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | Leaf | R-HSA-392499 | Metabolism of proteins |
| R-HSA-72764 | Eukaryotic Translation Termination | Leaf | R-HSA-392499 | Metabolism of proteins |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | Leaf | R-HSA-1266738 | Developmental Biology |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | Leaf | R-HSA-8953897 | Cellular responses to stimuli |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | Leaf | R-HSA-1643685 | Disease |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | Leaf | R-HSA-1643685 | Disease |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | Leaf | R-HSA-8953854 | Metabolism of RNA |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | Leaf | R-HSA-8953854 | Metabolism of RNA |
| Location
|
ECO term
|
Pubmed |
|---|
| HPO ID
|
HPO name |
|---|
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adipose tissue | adipocytes | Medium | Approved |
| adrenal gland | glandular cells | High | Approved |
| appendix | glandular cells | High | Approved |
| appendix | lymphoid tissue | Low | Approved |
| bone marrow | hematopoietic cells | High | Approved |
| breast | glandular cells | Medium | Approved |
| breast | myoepithelial cells | Medium | Approved |
| bronchus | respiratory epithelial cells | High | Approved |
| caudate | neuronal cells | Medium | Approved |
| cerebellum | Purkinje cells | High | Approved |
| cerebellum | cells in granular layer | Low | Approved |
| cerebellum | cells in molecular layer | Medium | Approved |
| cerebral cortex | neuronal cells | High | Approved |
| cervix | glandular cells | Medium | Approved |
| cervix | squamous epithelial cells | Medium | Approved |
| colon | endothelial cells | High | Approved |
| colon | glandular cells | High | Approved |
| duodenum | glandular cells | High | Approved |
| endometrium 1 | cells in endometrial stroma | Medium | Approved |
| endometrium 1 | glandular cells | High | Approved |
| endometrium 2 | cells in endometrial stroma | Medium | Approved |
| endometrium 2 | glandular cells | High | Approved |
| epididymis | glandular cells | Medium | Approved |
| esophagus | squamous epithelial cells | High | Approved |
| fallopian tube | glandular cells | Medium | Approved |
| gallbladder | glandular cells | Medium | Approved |
| heart muscle | cardiomyocytes | Low | Approved |
| hippocampus | glial cells | Low | Approved |
| hippocampus | neuronal cells | Medium | Approved |
| kidney | cells in glomeruli | Low | Approved |
| kidney | cells in tubules | Medium | Approved |
| liver | cholangiocytes | Low | Approved |
| liver | hepatocytes | Low | Approved |
| lung | alveolar cells | Low | Approved |
| lung | macrophages | High | Approved |
| lymph node | germinal center cells | High | Approved |
| lymph node | non-germinal center cells | Medium | Approved |
| nasopharynx | respiratory epithelial cells | High | Approved |
| oral mucosa | squamous epithelial cells | High | Approved |
| ovary | follicle cells | Low | Approved |
| ovary | ovarian stroma cells | Low | Approved |
| pancreas | exocrine glandular cells | High | Approved |
| pancreas | pancreatic endocrine cells | Medium | Approved |
| parathyroid gland | glandular cells | Low | Approved |
| placenta | trophoblastic cells | High | Approved |
| prostate | glandular cells | Medium | Approved |
| rectum | glandular cells | Medium | Approved |
| salivary gland | glandular cells | High | Approved |
| seminal vesicle | glandular cells | Medium | Approved |
| skin 1 | Langerhans | Medium | Approved |
| skin 1 | keratinocytes | Medium | Approved |
| skin 2 | epidermal cells | High | Approved |
| small intestine | glandular cells | High | Approved |
| soft tissue 1 | fibroblasts | Medium | Approved |
| soft tissue 1 | peripheral nerve | Low | Approved |
| spleen | cells in red pulp | Medium | Approved |
| spleen | cells in white pulp | High | Approved |
| stomach 1 | glandular cells | High | Approved |
| stomach 2 | glandular cells | High | Approved |
| testis | Leydig cells | High | Approved |
| testis | cells in seminiferous ducts | High | Approved |
| thyroid gland | glandular cells | Medium | Approved |
| tonsil | germinal center cells | High | Approved |
| tonsil | non-germinal center cells | Medium | Approved |
| tonsil | squamous epithelial cells | Medium | Approved |
| urinary bladder | urothelial cells | High | Approved |
| vagina | squamous epithelial cells | Medium | Approved |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|