Protein family
Protein sequence
Protein function
Catalytic activity
EC number
EC number description
2.3.1.155
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups;
acetyl-CoA C-myristoyltransferase
2.3.1.16
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups;
acetyl-CoA C-acyltransferase
2.3.1.176
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups;
propanoyl-CoA C-acyltransferase
GO ontology | GO term | GO description |
---|---|---|
Biological Process | GO:0036109 | alpha-linolenic acid metabolic process |
Biological Process | GO:0006699 | bile acid biosynthetic process |
Biological Process | GO:0008206 | bile acid metabolic process |
Biological Process | GO:0006635 | fatty acid beta-oxidation |
Biological Process | GO:0033540 | fatty acid beta-oxidation using acyl-CoA oxidase |
Biological Process | GO:0032959 | inositol trisphosphate biosynthetic process |
Biological Process | GO:0032367 | intracellular cholesterol transport |
Biological Process | GO:1901373 | lipid hydroperoxide transport |
Biological Process | GO:0015914 | phospholipid transport |
Biological Process | GO:0032385 | positive regulation of intracellular cholesterol transport |
Biological Process | GO:0045940 | positive regulation of steroid metabolic process |
Biological Process | GO:0006701 | progesterone biosynthetic process |
Biological Process | GO:0072659 | protein localization to plasma membrane |
Biological Process | GO:0071071 | regulation of phospholipid biosynthetic process |
Biological Process | GO:0006694 | steroid biosynthetic process |
Molecular Function | GO:0003988 | acetyl-CoA C-acyltransferase activity |
Molecular Function | GO:0050633 | acetyl-CoA C-myristoyltransferase activity |
Molecular Function | GO:0015485 | cholesterol binding |
Molecular Function | GO:0120020 | cholesterol transfer activity |
Molecular Function | GO:0000062 | fatty-acyl-CoA binding |
Molecular Function | GO:0036042 | long-chain fatty acyl-CoA binding |
Molecular Function | GO:0070538 | oleic acid binding |
Molecular Function | GO:0120019 | phosphatidylcholine transfer activity |
Molecular Function | GO:0008526 | phosphatidylinositol transfer activity |
Molecular Function | GO:0033814 | propanoyl-CoA C-acyltransferase activity |
Molecular Function | GO:0050632 | propionyl-CoA C2-trimethyltridecanoyltransferase activity |
Molecular Function | GO:0005102 | signaling receptor binding |
Molecular Function | GO:0032934 | sterol binding |
Cellular Component | GO:0005737 | cytoplasm |
Cellular Component | GO:0005829 | cytosol |
Cellular Component | GO:0005783 | endoplasmic reticulum |
Cellular Component | GO:0043231 | intracellular membrane-bounded organelle |
Cellular Component | GO:0016020 | membrane |
Cellular Component | GO:0005739 | mitochondrion |
Cellular Component | GO:0005654 | nucleoplasm |
Cellular Component | GO:0005782 | peroxisomal matrix |
Cellular Component | GO:0005777 | peroxisome |
Cellular Component | GO:0032991 | protein-containing complex |
InterPro | InterPro name |
---|---|
IPR003033 | SCP2 sterol-binding domain |
IPR016039 | Thiolase-like |
IPR020613 | Thiolase, conserved site |
IPR020615 | Thiolase, acyl-enzyme intermediate active site |
IPR020616 | Thiolase, N-terminal |
IPR020617 | Thiolase, C-terminal |
IPR036527 | SCP2 sterol-binding domain superfamily |
Pfam | Pfam name |
---|---|
PF00108 | Thiolase, N-terminal domain |
PF02036 | SCP-2 sterol transfer family |
PF02803 | Thiolase, C-terminal domain |
Reactome | Reactome Name | Node type | Reactome Root | Reactome Root Name |
---|---|---|---|---|
R-HSA-193368 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | Leaf | R-HSA-1430728 | Metabolism |
R-HSA-2046106 | alpha-linolenic acid (ALA) metabolism | Leaf | R-HSA-1430728 | Metabolism |
R-HSA-389887 | Beta-oxidation of pristanoyl-CoA | Leaf | R-HSA-1430728 | Metabolism |
R-HSA-9033241 | Peroxisomal protein import | Internal node | R-HSA-9609507 | Protein localization |
R-HSA-9033500 | TYSND1 cleaves peroxisomal proteins | Leaf | R-HSA-9609507 | Protein localization |
Location | ECO term | Pubmed |
---|---|---|
Cytoplasm | ECO:0000269 | PubMed:10706581 |
Cytoplasm | ECO:0000269 | PubMed:17157249 |
Endoplasmic reticulum | ECO:0000250 | |
Mitochondrion | ECO:0000269 | PubMed:17157249 |
Peroxisome | ECO:0000250 |
HPO ID | HPO name |
---|---|
HP:0000007 | Autosomal recessive inheritance |
HP:0000027 | Azoospermia |
HP:0000365 | Hearing impairment |
HP:0000473 | Torticollis |
HP:0000514 | Slow saccadic eye movements |
HP:0000815 | Hypergonadotropic hypogonadism |
HP:0001332 | Dystonia |
HP:0002080 | Intention tremor |
HP:0002346 | Head tremor |
HP:0002352 | Leukoencephalopathy |
HP:0002495 | Impaired vibratory sensation |
HP:0003431 | Decreased motor nerve conduction velocity |
HP:0003621 | Juvenile onset |
HP:0004409 | Hyposmia |
HP:0009830 | Peripheral neuropathy |
HP:0012692 | Focal T2 hyperintense thalamic lesion |
HP:0034721 | Elevated circulating pristanic acid concentration |
Disease name | MONDO ID | ICD10 | ICD10 chapter | OMIM | Orphanet |
---|---|---|---|---|---|
sterol carrier protein 2 deficiency | MONDO:0013391 | E75 | chapter4, Endocrine, nutritional and metabolic diseases | OMIM:613724 | Orphanet:163684 |