MultifacetedProtDB - Bologna Biocomputing Group

EC number	EC number description
2.7.13.3	Transferases; Transferring phosphorus-containing groups; Protein-histidine kinases; histidine kinase
2.7.4.6	Transferases; Transferring phosphorus-containing groups; Phosphotransferases with a phosphate group as acceptor; nucleoside-diphosphate kinase

Structure

PDB	Resolution (Å)	PDB name
1NSK	2.8	THE CRYSTAL STRUCTURE OF A HUMAN NUCLEOSIDE DIPHOSPHATE KINASE, NM23-H2
1NUE	2.0	X-RAY STRUCTURE OF NM23 HUMAN NUCLEOSIDE DIPHOSPHATE KINASE B COMPLEXED WITH GDP AT 2 ANGSTROMS RESOLUTION
3BBB	1.3	Crystal structure of the NM23-H2 transcription factor complex with dinucleotide d(AG)
3BBC	1.7	Crystal structure of R88A mutant of the NM23-H2 transcription factor
3BBF	1.7	Crystal structure of the NM23-H2 transcription factor complex with GDP
7KPF	2.23	NME2 bound to myristoyl-CoA

GO term

GO ontology	GO term	GO description
Biological Process	GO:0006241	CTP biosynthetic process
Biological Process	GO:0006183	GTP biosynthetic process
Biological Process	GO:0006228	UTP biosynthetic process
Biological Process	GO:0007155	cell adhesion
Biological Process	GO:0007229	integrin-mediated signaling pathway
Biological Process	GO:0043066	negative regulation of apoptotic process
Biological Process	GO:0009142	nucleoside triphosphate biosynthetic process
Biological Process	GO:0045893	positive regulation of DNA-templated transcription
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation
Biological Process	GO:0045618	positive regulation of keratinocyte differentiation
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II
Biological Process	GO:0042981	regulation of apoptotic process
Biological Process	GO:0045682	regulation of epidermis development
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0003677	DNA binding
Molecular Function	GO:0051880	G-quadruplex DNA binding
Molecular Function	GO:0019003	GDP binding
Molecular Function	GO:0046872	metal ion binding
Molecular Function	GO:0004550	nucleoside diphosphate kinase activity
Molecular Function	GO:0004673	protein histidine kinase activity
Molecular Function	GO:0003713	transcription coactivator activity
Cellular Component	GO:0071944	cell periphery
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0005576	extracellular region
Cellular Component	GO:1904813	ficolin-1-rich granule lumen
Cellular Component	GO:0030027	lamellipodium
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0048471	perinuclear region of cytoplasm
Cellular Component	GO:0001726	ruffle
Cellular Component	GO:0034774	secretory granule lumen

InterPro / Pfam

InterPro	InterPro name
IPR001564	Nucleoside diphosphate kinase
IPR023005	Nucleoside diphosphate kinase, active site
IPR034907	Nucleoside diphosphate kinase-like domain
IPR036850	Nucleoside diphosphate kinase-like domain superfamily

Pfam	Pfam name
PF00334	Nucleoside diphosphate kinase

Reactome

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-499943	Interconversion of nucleotide di- and triphosphates	Leaf	R-HSA-1430728	Metabolism
R-HSA-6798695	Neutrophil degranulation	Leaf	R-HSA-168256	Immune System
R-HSA-9748787	Azathioprine ADME	Leaf	R-HSA-9748784	Drug ADME
R-HSA-9755088	Ribavirin ADME	Leaf	R-HSA-9748784	Drug ADME

Subcellular location

Location	ECO term	Pubmed
Cell projection, lamellipodium	ECO:0000269	PubMed:11919189
Cell projection, ruffle	ECO:0000269	PubMed:11919189
Cytoplasm	ECO:0000269	PubMed:16442775
Cytoplasm	ECO:0000269	PubMed:17532299
Cytoplasm, perinuclear region	ECO:0000269	PubMed:16442775
Nucleus	ECO:0000269	PubMed:16442775

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Tissue	Cell type	Expression level	Reliability
adrenal gland	glandular cells	Medium	Approved
appendix	glandular cells	Medium	Approved
appendix	lymphoid tissue	Medium	Approved
bone marrow	hematopoietic cells	Medium	Approved
breast	glandular cells	Low	Approved
bronchus	respiratory epithelial cells	Medium	Approved
caudate	neuronal cells	Medium	Approved
cerebellum	Purkinje cells	Medium	Approved
cerebellum	cells in granular layer	Medium	Approved
cerebral cortex	neuronal cells	Medium	Approved
cerebral cortex	neuropil	Medium	Approved
cervix	glandular cells	Medium	Approved
cervix	squamous epithelial cells	Medium	Approved
colon	endothelial cells	Medium	Approved
colon	glandular cells	Medium	Approved
colon	peripheral nerve/ganglion	Medium	Approved
duodenum	glandular cells	Medium	Approved
endometrium 1	glandular cells	Medium	Approved
endometrium 2	cells in endometrial stroma	Medium	Approved
endometrium 2	glandular cells	High	Approved
epididymis	glandular cells	Medium	Approved
esophagus	squamous epithelial cells	Medium	Approved
fallopian tube	glandular cells	Medium	Approved
gallbladder	glandular cells	Low	Approved
hippocampus	glial cells	Medium	Approved
hippocampus	neuronal cells	Medium	Approved
kidney	cells in tubules	High	Approved
liver	cholangiocytes	Low	Approved
liver	hepatocytes	Low	Approved
lung	macrophages	Low	Approved
lymph node	germinal center cells	Medium	Approved
lymph node	non-germinal center cells	High	Approved
nasopharynx	respiratory epithelial cells	High	Approved
oral mucosa	squamous epithelial cells	Medium	Approved
ovary	ovarian stroma cells	Low	Approved
pancreas	exocrine glandular cells	Medium	Approved
pancreas	pancreatic endocrine cells	Low	Approved
parathyroid gland	glandular cells	Medium	Approved
placenta	decidual cells	Low	Approved
placenta	trophoblastic cells	Medium	Approved
prostate	glandular cells	High	Approved
rectum	glandular cells	High	Approved
salivary gland	glandular cells	Medium	Approved
seminal vesicle	glandular cells	Medium	Approved
skin 1	fibroblasts	Medium	Approved
skin 1	melanocytes	Medium	Approved
skin 2	epidermal cells	Medium	Approved
small intestine	glandular cells	Medium	Approved
soft tissue 1	peripheral nerve	Low	Approved
soft tissue 2	chondrocytes	High	Approved
spleen	cells in red pulp	Low	Approved
spleen	cells in white pulp	Medium	Approved
stomach 1	glandular cells	High	Approved
stomach 2	glandular cells	Medium	Approved
testis	Leydig cells	Medium	Approved
testis	cells in seminiferous ducts	Medium	Approved
thyroid gland	glandular cells	Medium	Approved
tonsil	germinal center cells	Medium	Approved
tonsil	non-germinal center cells	Low	Approved
tonsil	squamous epithelial cells	Low	Approved
urinary bladder	urothelial cells	High	Approved
vagina	squamous epithelial cells	Medium	Approved

Disease

Summary of P22392

Gene: NME2, NM23B
Protein: Nucleoside diphosphate kinase B

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of P22392

Gene: NME2, NM23B Protein: Nucleoside diphosphate kinase B

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: NME2, NM23B
Protein: Nucleoside diphosphate kinase B