Protein family
Protein sequence
Protein function
Catalytic activity
EC number
EC number description
3.1.1.1
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases;
carboxylesterase
3.1.1.13
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases;
sterol esterase
3.1.1.56
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases;
methylumbelliferyl-acetate deacetylase
PDB | Resolution (Å) | PDB name |
---|---|---|
1MX1 | 2.4 | Crystal Structure of Human Liver Carboxylesterase in complex with tacrine |
1MX5 | 2.8 | Crystal Structure of Human Liver Carboxylesterase in complexed with homatropine, a cocaine analogue |
1MX9 | 2.9 | Crystal Structure of Human Liver Carboxylesterase in complexed with naloxone methiodide, a heroin analogue |
1YA4 | 3.2 | Crystal Structure of Human Liver Carboxylesterase 1 in complex with tamoxifen |
1YA8 | 3.0 | Crystal Structure of Human Liver Carboxylesterase in complex with cleavage products of Mevastatin |
1YAH | 3.0 | Crystal Structure of Human Liver Carboxylesterase complexed to Etyl Acetate; A Fatty Acid Ethyl Ester Analogue |
1YAJ | 3.2 | Crystal Structure of Human Liver Carboxylesterase in complex with benzil |
2DQY | 3.0 | Crystal structure of human carboxylesterase in complex with cholate and palmitate |
2DQZ | 2.8 | Crystal structure of human carboxylesterase in complex with homatropine, coenzyme A, and palmitate |
2DR0 | 3.2 | Crystal structure of human carboxylesterase in complex with taurocholate |
2H7C | 2.0 | Crystal structure of human carboxylesterase in complex with Coenzyme A |
2HRQ | 2.7 | Crystal structure of Human Liver Carboxylesterase 1 (hCE1) in covalent complex with the nerve agent Soman (GD) |
2HRR | 2.7 | Crystal structure of Human Liver Carboxylesterase 1 (hCE1) in covalent complex with the nerve agent Tabun (GA) |
3K9B | 3.1 | Crystal structure of human liver carboxylesterase 1 (hCE1) in covalent complex with the nerve agent Cyclosarin (GF) |
4AB1 | 2.2 | Recombinant Human Carboxylesterase 1 from whole Cabbage Loopers |
5A7F | 1.86 | Comparison of the structure and activity of glycosylated and aglycosylated Human Carboxylesterase 1 |
5A7G | 1.48 | Comparison of the structure and activity of glycosylated and aglycosylated Human Carboxylesterase 1 |
5A7H | 2.01 | Comparison of the structure and activity of glycosylated and aglycosylated Human Carboxylesterase 1 |
GO ontology | GO term | GO description |
---|---|---|
Biological Process | GO:0071397 | cellular response to cholesterol |
Biological Process | GO:0071404 | cellular response to low-density lipoprotein particle stimulus |
Biological Process | GO:0006695 | cholesterol biosynthetic process |
Biological Process | GO:0090122 | cholesterol ester hydrolysis involved in cholesterol transport |
Biological Process | GO:0042632 | cholesterol homeostasis |
Biological Process | GO:0008203 | cholesterol metabolic process |
Biological Process | GO:0030855 | epithelial cell differentiation |
Biological Process | GO:0016042 | lipid catabolic process |
Biological Process | GO:0051791 | medium-chain fatty acid metabolic process |
Biological Process | GO:0010887 | negative regulation of cholesterol storage |
Biological Process | GO:0010875 | positive regulation of cholesterol efflux |
Biological Process | GO:0090205 | positive regulation of cholesterol metabolic process |
Biological Process | GO:0070857 | regulation of bile acid biosynthetic process |
Biological Process | GO:0120188 | regulation of bile acid secretion |
Biological Process | GO:0009636 | response to toxic substance |
Biological Process | GO:0043691 | reverse cholesterol transport |
Molecular Function | GO:0106435 | carboxylesterase activity |
Molecular Function | GO:0052689 | carboxylic ester hydrolase activity |
Molecular Function | GO:0047374 | methylumbelliferyl-acetate deacetylase activity |
Molecular Function | GO:0004771 | sterol esterase activity |
Cellular Component | GO:0005737 | cytoplasm |
Cellular Component | GO:0005829 | cytosol |
Cellular Component | GO:0005783 | endoplasmic reticulum |
Cellular Component | GO:0005788 | endoplasmic reticulum lumen |
Cellular Component | GO:0005811 | lipid droplet |
Reactome | Reactome Name | Node type | Reactome Root | Reactome Root Name |
---|---|---|---|---|
R-HSA-2022377 | Metabolism of Angiotensinogen to Angiotensins | Leaf | R-HSA-392499 | Metabolism of proteins |
R-HSA-211945 | Phase I - Functionalization of compounds | Internal node | R-HSA-1430728 | Metabolism |
R-HSA-5578768 | Physiological factors | Leaf | R-HSA-397014 | Muscle contraction |
R-HSA-9749641 | Aspirin ADME | Leaf | R-HSA-9748784 | Drug ADME |
Location | ECO term | Pubmed |
---|---|---|
Cytoplasm | ECO:0000269 | PubMed:16024911 |
Endoplasmic reticulum lumen | ECO:0000269 | PubMed:10562416 |
Lipid droplet | ECO:0000269 | PubMed:16024911 |
HPO ID | HPO name |
---|---|
HP:0000006 | Autosomal dominant inheritance |
HP:0020169 | Abnormal drug response |