Protein family
Protein sequence
Protein function
Catalytic activity
EC number
EC number description
3.1.1.1
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases;
carboxylesterase
3.1.1.13
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases;
sterol esterase
3.1.1.56
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases;
methylumbelliferyl-acetate deacetylase
| PDB | Resolution (Å) | PDB name |
|---|---|---|
| 1MX1 | 2.4 | Crystal Structure of Human Liver Carboxylesterase in complex with tacrine |
| 1MX5 | 2.8 | Crystal Structure of Human Liver Carboxylesterase in complexed with homatropine, a cocaine analogue |
| 1MX9 | 2.9 | Crystal Structure of Human Liver Carboxylesterase in complexed with naloxone methiodide, a heroin analogue |
| 1YA4 | 3.2 | Crystal Structure of Human Liver Carboxylesterase 1 in complex with tamoxifen |
| 1YA8 | 3.0 | Crystal Structure of Human Liver Carboxylesterase in complex with cleavage products of Mevastatin |
| 1YAH | 3.0 | Crystal Structure of Human Liver Carboxylesterase complexed to Etyl Acetate; A Fatty Acid Ethyl Ester Analogue |
| 1YAJ | 3.2 | Crystal Structure of Human Liver Carboxylesterase in complex with benzil |
| 2DQY | 3.0 | Crystal structure of human carboxylesterase in complex with cholate and palmitate |
| 2DQZ | 2.8 | Crystal structure of human carboxylesterase in complex with homatropine, coenzyme A, and palmitate |
| 2DR0 | 3.2 | Crystal structure of human carboxylesterase in complex with taurocholate |
| 2H7C | 2.0 | Crystal structure of human carboxylesterase in complex with Coenzyme A |
| 2HRQ | 2.7 | Crystal structure of Human Liver Carboxylesterase 1 (hCE1) in covalent complex with the nerve agent Soman (GD) |
| 2HRR | 2.7 | Crystal structure of Human Liver Carboxylesterase 1 (hCE1) in covalent complex with the nerve agent Tabun (GA) |
| 3K9B | 3.1 | Crystal structure of human liver carboxylesterase 1 (hCE1) in covalent complex with the nerve agent Cyclosarin (GF) |
| 4AB1 | 2.2 | Recombinant Human Carboxylesterase 1 from whole Cabbage Loopers |
| 5A7F | 1.86 | Comparison of the structure and activity of glycosylated and aglycosylated Human Carboxylesterase 1 |
| 5A7G | 1.48 | Comparison of the structure and activity of glycosylated and aglycosylated Human Carboxylesterase 1 |
| 5A7H | 2.01 | Comparison of the structure and activity of glycosylated and aglycosylated Human Carboxylesterase 1 |
| GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0071397 | cellular response to cholesterol |
| Biological Process | GO:0071404 | cellular response to low-density lipoprotein particle stimulus |
| Biological Process | GO:0006695 | cholesterol biosynthetic process |
| Biological Process | GO:0090122 | cholesterol ester hydrolysis involved in cholesterol transport |
| Biological Process | GO:0042632 | cholesterol homeostasis |
| Biological Process | GO:0008203 | cholesterol metabolic process |
| Biological Process | GO:0030855 | epithelial cell differentiation |
| Biological Process | GO:0016042 | lipid catabolic process |
| Biological Process | GO:0051791 | medium-chain fatty acid metabolic process |
| Biological Process | GO:0010887 | negative regulation of cholesterol storage |
| Biological Process | GO:0010875 | positive regulation of cholesterol efflux |
| Biological Process | GO:0090205 | positive regulation of cholesterol metabolic process |
| Biological Process | GO:0070857 | regulation of bile acid biosynthetic process |
| Biological Process | GO:0120188 | regulation of bile acid secretion |
| Biological Process | GO:0009636 | response to toxic substance |
| Biological Process | GO:0043691 | reverse cholesterol transport |
| Molecular Function | GO:0106435 | carboxylesterase activity |
| Molecular Function | GO:0052689 | carboxylic ester hydrolase activity |
| Molecular Function | GO:0047374 | methylumbelliferyl-acetate deacetylase activity |
| Molecular Function | GO:0004771 | sterol esterase activity |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005788 | endoplasmic reticulum lumen |
| Cellular Component | GO:0005811 | lipid droplet |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-2022377 | Metabolism of Angiotensinogen to Angiotensins | Leaf | R-HSA-392499 | Metabolism of proteins |
| R-HSA-211945 | Phase I - Functionalization of compounds | Internal node | R-HSA-1430728 | Metabolism |
| R-HSA-5578768 | Physiological factors | Leaf | R-HSA-397014 | Muscle contraction |
| R-HSA-9749641 | Aspirin ADME | Leaf | R-HSA-9748784 | Drug ADME |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Cytoplasm | ECO:0000269 | PubMed:16024911 |
| Endoplasmic reticulum lumen | ECO:0000269 | PubMed:10562416 |
| Lipid droplet | ECO:0000269 | PubMed:16024911 |
| HPO ID
|
HPO name |
|---|---|
| HP:0000006 | Autosomal dominant inheritance |
| HP:0020169 | Abnormal drug response |