Protein family
Protein sequence
Protein function
Publications
Catalytic activity
EC number
EC number description
1.14.99.1
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
Miscellaneous;
prostaglandin-endoperoxide synthase
| PDB | Resolution (Å) | PDB name |
|---|---|---|
| 6Y3C | 3.361 | Human COX-1 Crystal Structure |
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0019371 | cyclooxygenase pathway |
| Biological Process | GO:0001516 | prostaglandin biosynthetic process |
| Biological Process | GO:0008217 | regulation of blood pressure |
| Biological Process | GO:0042127 | regulation of cell population proliferation |
| Biological Process | GO:0006979 | response to oxidative stress |
| Molecular Function | GO:0020037 | heme binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0016702 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen |
| Molecular Function | GO:0004601 | peroxidase activity |
| Molecular Function | GO:0004666 | prostaglandin-endoperoxide synthase activity |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0043231 | intracellular membrane-bounded organelle |
| Cellular Component | GO:0043005 | neuron projection |
| Cellular Component | GO:0001750 | photoreceptor outer segment |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-140180 | COX reactions | Leaf | R-HSA-1430728 | Metabolism |
| R-HSA-2162123 | Synthesis of Prostaglandins (PG) and Thromboxanes (TX) | Leaf | R-HSA-1430728 | Metabolism |
| HPO ID
|
HPO name |
|---|
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| appendix | endocrine cells | High | Enhanced |
| appendix | enterocytes | Low | Enhanced |
| appendix | germinal center cells | Medium | Enhanced |
| appendix | non-germinal center cells | Low | Enhanced |
| bone marrow | hematopoietic cells | Medium | Enhanced |
| breast | glandular cells | Low | Enhanced |
| breast | myoepithelial cells | Low | Enhanced |
| caudate | glial cells | Medium | Enhanced |
| cerebellum | cells in granular layer | Low | Enhanced |
| cerebellum | cells in molecular layer | Medium | Enhanced |
| cerebral cortex | glial cells | Medium | Enhanced |
| cerebral cortex | neuronal cells | Low | Enhanced |
| cervix | glandular cells | Low | Enhanced |
| cervix | squamous epithelial cells | Medium | Enhanced |
| colon | endocrine cells | High | Enhanced |
| colon | endothelial cells | High | Enhanced |
| colon | enterocytes | Medium | Enhanced |
| colon | mucosal lymphoid cells | High | Enhanced |
| duodenum | endocrine cells | High | Enhanced |
| endometrium 1 | cells in endometrial stroma | Low | Enhanced |
| endometrium 1 | glandular cells | High | Enhanced |
| endometrium 2 | cells in endometrial stroma | Low | Enhanced |
| endometrium 2 | glandular cells | Medium | Enhanced |
| epididymis | glandular cells | Low | Enhanced |
| esophagus | squamous epithelial cells | Medium | Enhanced |
| fallopian tube | glandular cells | High | Enhanced |
| gallbladder | glandular cells | Low | Enhanced |
| hippocampus | glial cells | Medium | Enhanced |
| hippocampus | neuronal cells | Medium | Enhanced |
| kidney | cells in glomeruli | Low | Enhanced |
| liver | cholangiocytes | Low | Enhanced |
| lung | endothelial cells | High | Enhanced |
| lung | macrophages | Medium | Enhanced |
| lymph node | non-germinal center cells | Medium | Enhanced |
| oral mucosa | squamous epithelial cells | Medium | Enhanced |
| pancreas | exocrine glandular cells | Low | Enhanced |
| pancreas | pancreatic endocrine cells | Low | Enhanced |
| placenta | trophoblastic cells | Low | Enhanced |
| rectum | endocrine cells | High | Enhanced |
| rectum | endothelial cells | High | Enhanced |
| rectum | mucosal lymphoid cells | High | Enhanced |
| seminal vesicle | glandular cells | Medium | Enhanced |
| skeletal muscle | myocytes | Low | Enhanced |
| skin 1 | cells in granular layer | High | Enhanced |
| skin 1 | cells in spinous layer | High | Enhanced |
| skin 1 | endothelial cells | High | Enhanced |
| skin 1 | fibrohistiocytic cells | High | Enhanced |
| skin 1 | langerhans cells | High | Enhanced |
| skin 1 | lymphocytes | High | Enhanced |
| skin 1 | melanocytes | Medium | Enhanced |
| skin 2 | cells in granular layer | High | Enhanced |
| skin 2 | cells in spinous layer | High | Enhanced |
| skin 2 | endothelial cells | High | Enhanced |
| skin 2 | fibrohistiocytic cells | High | Enhanced |
| skin 2 | langerhans cells | High | Enhanced |
| skin 2 | lymphocytes | High | Enhanced |
| small intestine | endocrine cells | High | Enhanced |
| small intestine | paneth cells | Low | Enhanced |
| smooth muscle | smooth muscle cells | Medium | Enhanced |
| stomach 1 | glandular cells | Low | Enhanced |
| stomach 2 | glandular cells | Low | Enhanced |
| testis | Leydig cells | Low | Enhanced |
| tonsil | non-germinal center cells | Medium | Enhanced |
| tonsil | squamous epithelial cells | High | Enhanced |
| urinary bladder | urothelial cells | Low | Enhanced |
| vagina | squamous epithelial cells | Low | Enhanced |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|