Protein family
Protein sequence
Protein function
Catalytic activity
EC number
EC number description
6.1.1.2
Ligases;
Forming carbon-oxygen bonds;
Ligases forming aminoacyl-tRNA and related compounds;
tryptophan—tRNA ligase
PDB | Resolution (Å) | PDB name |
---|---|---|
1O5T | 2.5 | Crystal structure of the aminoacylation catalytic fragment of human tryptophanyl-tRNA synthetase |
1R6T | 2.1 | crystal structure of human tryptophanyl-tRNA synthetase |
1R6U | 2.0 | Crystal structure of an active fragment of human tryptophanyl-tRNA synthetase with cytokine activity |
1ULH | 2.31 | A short peptide insertion crucial for angiostatic activity of human tryptophanyl-tRNA synthetase |
2AKE | 3.1 | Structure of human tryptophanyl-tRNA synthetase in complex with tRNA(Trp) |
2AZX | 2.8 | Charged and uncharged tRNAs adopt distinct conformations when complexed with human tryptophanyl-tRNA synthetase |
2DR2 | 3.0 | Structure of human tryptophanyl-tRNA synthetase in complex with tRNA(Trp) |
2QUH | 2.4 | Crystal structures of human tryptophanyl-tRNA synthetase in complex with Trp |
2QUI | 2.4 | Crystal structures of human tryptophanyl-tRNA synthetase in complex with Tryptophanamide and ATP |
2QUJ | 2.42 | Crystal structures of human tryptophanyl-tRNA synthetase in complex with TrpAMP |
2QUK | 2.8 | Crystal structures of human tryptophanyl-tRNA synthetase in complex with ATP(putative) |
5UJI | 2.79 | Crystal structure of human T2-Tryptophanyl-tRNA synthetase with H130R mutation |
5UJJ | 2.1 | Crystal structure of human H130R tryptophanyl-tRNA synthetase in complex with TrpAMP |
GO ontology | GO term | GO description |
---|---|---|
Biological Process | GO:0001525 | angiogenesis |
Biological Process | GO:0008285 | negative regulation of cell population proliferation |
Biological Process | GO:0006469 | negative regulation of protein kinase activity |
Biological Process | GO:0010628 | positive regulation of gene expression |
Biological Process | GO:0031334 | positive regulation of protein-containing complex assembly |
Biological Process | GO:0045765 | regulation of angiogenesis |
Biological Process | GO:0006412 | translation |
Biological Process | GO:0006436 | tryptophanyl-tRNA aminoacylation |
Molecular Function | GO:0005524 | ATP binding |
Molecular Function | GO:0019210 | kinase inhibitor activity |
Molecular Function | GO:0019904 | protein domain specific binding |
Molecular Function | GO:0042803 | protein homodimerization activity |
Molecular Function | GO:0019901 | protein kinase binding |
Molecular Function | GO:0004830 | tryptophan-tRNA ligase activity |
Cellular Component | GO:0005737 | cytoplasm |
Cellular Component | GO:0005829 | cytosol |
Cellular Component | GO:0070062 | extracellular exosome |
Cellular Component | GO:0005634 | nucleus |
Cellular Component | GO:0032991 | protein-containing complex |
InterPro | InterPro name |
---|---|
IPR000738 | WHEP-TRS domain |
IPR001412 | Aminoacyl-tRNA synthetase, class I, conserved site |
IPR002305 | Aminoacyl-tRNA synthetase, class Ic |
IPR002306 | Tryptophan-tRNA ligase |
IPR009068 | S15/NS1, RNA-binding |
IPR014729 | Rossmann-like alpha/beta/alpha sandwich fold |
Pfam | Pfam name |
---|---|
PF00458 | WHEP-TRS domain |
PF00579 | tRNA synthetases class I (W and Y) |
Reactome | Reactome Name | Node type | Reactome Root | Reactome Root Name |
---|---|---|---|---|
R-HSA-379716 | Cytosolic tRNA aminoacylation | Leaf | R-HSA-392499 | Metabolism of proteins |
HPO ID | HPO name |
---|---|
HP:0000006 | Autosomal dominant inheritance |
HP:0001265 | Hyporeflexia |
HP:0001761 | Pes cavus |
HP:0002355 | Difficulty walking |
HP:0003438 | Absent Achilles reflex |
HP:0003621 | Juvenile onset |
HP:0003677 | Slowly progressive |
HP:0006844 | Absent patellar reflexes |
HP:0007002 | Motor axonal neuropathy |
HP:0007149 | Distal upper limb amyotrophy |
HP:0008944 | Distal lower limb amyotrophy |
HP:0008959 | Distal upper limb muscle weakness |
HP:0009053 | Distal lower limb muscle weakness |
Disease name | MONDO ID | ICD10 | ICD10 chapter | OMIM | Orphanet |
---|---|---|---|---|---|
neuronopathy, distal hereditary motor, type 9 | MONDO:0060585 | G12 | chapter6, Diseases of the nervous system | OMIM:617721 | |
neuronopathy, distal hereditary motor, type 9 | MONDO:0060585 | G62 | chapter6, Diseases of the nervous system | OMIM:617721 |