Protein family
Protein sequence
Protein function
Catalytic activity
EC number
EC number description
4.2.99.18
Lyases;
Carbon-oxygen lyases;
Other carbon-oxygen lyases;
DNA-(apurinic or apyrimidinic site) lyase
PDB | Resolution (Å) | PDB name |
---|---|---|
1WH9 | Solution structure of the KH domain of human ribosomal protein S3 | |
4UG0 | 3.6 | STRUCTURE OF THE HUMAN 80S RIBOSOME |
4V6X | 5.0 | Structure of the human 80S ribosome |
5A2Q | 3.9 | Structure of the HCV IRES bound to the human ribosome |
5AJ0 | 3.5 | Cryo electron microscopy of actively translating human polysomes (POST state). |
5FLX | 3.9 | Mammalian 40S HCV-IRES complex |
5LKS | 3.6 | Structure-function insights reveal the human ribosome as a cancer target for antibiotics |
5OA3 | 4.2 | Human 40S-eIF2D-re-initiation complex |
5T2C | 3.6 | CryoEM structure of the human ribosome at 3.6 Angstrom resolution |
5VYC | 6.0 | Crystal structure of the human 40S ribosomal subunit in complex with DENR-MCT-1. |
6FEC | 6.3 | Human cap-dependent 48S pre-initiation complex |
6G51 | 4.1 | Cryo-EM structure of a late human pre-40S ribosomal subunit - State D |
6G53 | 4.5 | Cryo-EM structure of a late human pre-40S ribosomal subunit - State E |
6G5H | 3.6 | Cryo-EM structure of a late human pre-40S ribosomal subunit - Mature |
6G5I | 3.5 | Cryo-EM structure of a late human pre-40S ribosomal subunit - State R |
6IP5 | 3.9 | Cryo-EM structure of the CMV-stalled human 80S ribosome (Structure ii) |
6IP6 | 4.5 | Cryo-EM structure of the CMV-stalled human 80S ribosome with HCV IRES (Structure iii) |
6IP8 | 3.9 | Cryo-EM structure of the HCV IRES dependently initiated CMV-stalled 80S ribosome (Structure iv) |
6OLE | 3.1 | Human ribosome nascent chain complex (CDH1-RNC) stalled by a drug-like molecule with AP and PE tRNAs |
6OLF | 3.9 | Human ribosome nascent chain complex (CDH1-RNC) stalled by a drug-like molecule with AA and PE tRNAs |
6OLG | 3.4 | Human ribosome nascent chain complex stalled by a drug-like small molecule (CDH1_RNC with PP tRNA) |
6OLI | 3.5 | Structure of human ribosome nascent chain complex selectively stalled by a drug-like small molecule (USO1-RNC) |
6OLZ | 3.9 | Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like molecule with PP tRNA |
6OM0 | 3.1 | Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like molecule with AP and PE tRNAs |
6OM7 | 3.7 | Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like small molecule with AA and PE tRNAs |
6QZP | 2.9 | High-resolution cryo-EM structure of the human 80S ribosome |
6XA1 | 2.8 | Structure of a drug-like compound stalled human translation termination complex |
6Y0G | 3.2 | Structure of human ribosome in classical-PRE state |
6Y2L | 3.0 | Structure of human ribosome in POST state |
6Y57 | 3.5 | Structure of human ribosome in hybrid-PRE state |
6YBS | 3.1 | Structure of a human 48S translational initiation complex - head |
6Z6L | 3.0 | Cryo-EM structure of human CCDC124 bound to 80S ribosomes |
6Z6M | 3.1 | Cryo-EM structure of human 80S ribosomes bound to EBP1, eEF2 and SERBP1 |
6Z6N | 2.9 | Cryo-EM structure of human EBP1-80S ribosomes (focus on EBP1) |
6ZLW | 2.6 | SARS-CoV-2 Nsp1 bound to the human 40S ribosomal subunit |
6ZM7 | 2.7 | SARS-CoV-2 Nsp1 bound to the human CCDC124-80S-EBP1 ribosome complex |
6ZME | 3.0 | SARS-CoV-2 Nsp1 bound to the human CCDC124-80S-eERF1 ribosome complex |
6ZMI | 2.6 | SARS-CoV-2 Nsp1 bound to the human LYAR-80S ribosome complex |
6ZMO | 3.1 | SARS-CoV-2 Nsp1 bound to the human LYAR-80S-eEF1a ribosome complex |
6ZMT | 3.0 | SARS-CoV-2 Nsp1 bound to a pre-40S-like ribosome complex |
6ZMW | 3.7 | Structure of a human 48S translational initiation complex |
6ZN5 | 3.2 | SARS-CoV-2 Nsp1 bound to a pre-40S-like ribosome complex - state 2 |
6ZOJ | 2.8 | SARS-CoV-2-Nsp1-40S complex, composite map |
6ZOL | 2.8 | SARS-CoV-2-Nsp1-40S complex, focused on head |
6ZON | 3.0 | SARS-CoV-2 Nsp1 bound to a human 43S preinitiation ribosome complex - state 1 |
6ZP4 | 2.9 | SARS-CoV-2 Nsp1 bound to a human 43S preinitiation ribosome complex - state 2 |
6ZUO | 3.1 | Human RIO1(kd)-StHA late pre-40S particle, structural state A (pre 18S rRNA cleavage) |
6ZV6 | 2.9 | Human RIO1(kd)-StHA late pre-40S particle, structural state B (post 18S rRNA cleavage) |
6ZVH | 2.9 | EDF1-ribosome complex |
6ZVJ | 3.8 | Structure of a human ABCE1-bound 43S pre-initiation complex - State II |
6ZXD | 3.2 | Cryo-EM structure of a late human pre-40S ribosomal subunit - State F1 |
6ZXE | 3.0 | Cryo-EM structure of a late human pre-40S ribosomal subunit - State F2 |
6ZXF | 3.7 | Cryo-EM structure of a late human pre-40S ribosomal subunit - State G |
6ZXG | 2.6 | Cryo-EM structure of a late human pre-40S ribosomal subunit - State H1 |
6ZXH | 2.7 | Cryo-EM structure of a late human pre-40S ribosomal subunit - State H2 |
7A09 | 3.5 | Structure of a human ABCE1-bound 43S pre-initiation complex - State III |
7K5I | 2.9 | SARS-COV-2 nsp1 in complex with human 40S ribosome |
7QP6 | 4.7 | Structure of the human 48S initiation complex in open state (h48S AUG open) |
7QP7 | 3.7 | Structure of the human 48S initiation complex in closed state (h48S AUG closed) |
7QVP | 3.0 | Human collided disome (di-ribosome) stalled on XBP1 mRNA |
7R4X | 2.15 | Cryo-EM reconstruction of the human 40S ribosomal subunit - Full map |
7TQL | 3.2 | CryoEM structure of the human 40S small ribosomal subunit in complex with translation initiation factors eIF1A and eIF5B. |
GO ontology | GO term | GO description |
---|---|---|
Biological Process | GO:0006974 | DNA damage response |
Biological Process | GO:0006281 | DNA repair |
Biological Process | GO:0006915 | apoptotic process |
Biological Process | GO:0051301 | cell division |
Biological Process | GO:0070301 | cellular response to hydrogen peroxide |
Biological Process | GO:0034614 | cellular response to reactive oxygen species |
Biological Process | GO:0071356 | cellular response to tumor necrosis factor |
Biological Process | GO:0007059 | chromosome segregation |
Biological Process | GO:0002181 | cytoplasmic translation |
Biological Process | GO:0045738 | negative regulation of DNA repair |
Biological Process | GO:0031397 | negative regulation of protein ubiquitination |
Biological Process | GO:0017148 | negative regulation of translation |
Biological Process | GO:1902546 | positive regulation of DNA N-glycosylase activity |
Biological Process | GO:0045739 | positive regulation of DNA repair |
Biological Process | GO:0043507 | positive regulation of JUN kinase activity |
Biological Process | GO:0051092 | positive regulation of NF-kappaB transcription factor activity |
Biological Process | GO:1901224 | positive regulation of NIK/NF-kappaB signaling |
Biological Process | GO:0050862 | positive regulation of T cell receptor signaling pathway |
Biological Process | GO:0042104 | positive regulation of activated T cell proliferation |
Biological Process | GO:2001235 | positive regulation of apoptotic signaling pathway |
Biological Process | GO:1905053 | positive regulation of base-excision repair |
Biological Process | GO:2001272 | positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis |
Biological Process | GO:0032079 | positive regulation of endodeoxyribonuclease activity |
Biological Process | GO:0010628 | positive regulation of gene expression |
Biological Process | GO:0032743 | positive regulation of interleukin-2 production |
Biological Process | GO:1902231 | positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage |
Biological Process | GO:0031116 | positive regulation of microtubule polymerization |
Biological Process | GO:0031334 | positive regulation of protein-containing complex assembly |
Biological Process | GO:0042981 | regulation of apoptotic process |
Biological Process | GO:0061481 | response to TNF agonist |
Biological Process | GO:0051225 | spindle assembly |
Biological Process | GO:0006412 | translation |
Biological Process | GO:0006413 | translational initiation |
Molecular Function | GO:0003677 | DNA binding |
Molecular Function | GO:0004520 | DNA endonuclease activity |
Molecular Function | GO:0003906 | DNA-(apurinic or apyrimidinic site) endonuclease activity |
Molecular Function | GO:0140297 | DNA-binding transcription factor binding |
Molecular Function | GO:0030544 | Hsp70 protein binding |
Molecular Function | GO:0051879 | Hsp90 protein binding |
Molecular Function | GO:0003723 | RNA binding |
Molecular Function | GO:0140078 | class I DNA-(apurinic or apyrimidinic site) endonuclease activity |
Molecular Function | GO:0003684 | damaged DNA binding |
Molecular Function | GO:0019899 | enzyme binding |
Molecular Function | GO:0051536 | iron-sulfur cluster binding |
Molecular Function | GO:0019900 | kinase binding |
Molecular Function | GO:0003729 | mRNA binding |
Molecular Function | GO:0008017 | microtubule binding |
Molecular Function | GO:0032357 | oxidized purine DNA binding |
Molecular Function | GO:0032358 | oxidized pyrimidine DNA binding |
Molecular Function | GO:0051018 | protein kinase A binding |
Molecular Function | GO:0019901 | protein kinase binding |
Molecular Function | GO:0044877 | protein-containing complex binding |
Molecular Function | GO:0070181 | small ribosomal subunit rRNA binding |
Molecular Function | GO:0003735 | structural constituent of ribosome |
Molecular Function | GO:0097100 | supercoiled DNA binding |
Molecular Function | GO:0015631 | tubulin binding |
Molecular Function | GO:0044390 | ubiquitin-like protein conjugating enzyme binding |
Cellular Component | GO:0071159 | NF-kappaB complex |
Cellular Component | GO:0005737 | cytoplasm |
Cellular Component | GO:0005829 | cytosol |
Cellular Component | GO:0022626 | cytosolic ribosome |
Cellular Component | GO:0022627 | cytosolic small ribosomal subunit |
Cellular Component | GO:0005783 | endoplasmic reticulum |
Cellular Component | GO:0070062 | extracellular exosome |
Cellular Component | GO:0005925 | focal adhesion |
Cellular Component | GO:0016020 | membrane |
Cellular Component | GO:0005743 | mitochondrial inner membrane |
Cellular Component | GO:0005759 | mitochondrial matrix |
Cellular Component | GO:0072686 | mitotic spindle |
Cellular Component | GO:0005730 | nucleolus |
Cellular Component | GO:0005654 | nucleoplasm |
Cellular Component | GO:0005634 | nucleus |
Cellular Component | GO:0005886 | plasma membrane |
Cellular Component | GO:0005844 | polysome |
Cellular Component | GO:0014069 | postsynaptic density |
Cellular Component | GO:1990904 | ribonucleoprotein complex |
Cellular Component | GO:0005840 | ribosome |
Cellular Component | GO:0032587 | ruffle membrane |
InterPro | InterPro name |
---|---|
IPR001351 | Ribosomal protein S3, C-terminal |
IPR004044 | K Homology domain, type 2 |
IPR005703 | Ribosomal protein S3, eukaryotic/archaeal |
IPR009019 | K homology domain superfamily, prokaryotic type |
IPR015946 | K homology domain-like, alpha/beta |
IPR018280 | Ribosomal protein S3, conserved site |
IPR036419 | Ribosomal protein S3, C-terminal domain superfamily |
Pfam | Pfam name |
---|---|
PF00189 | Ribosomal protein S3, C-terminal domain |
PF07650 | KH domain |
Reactome | Reactome Name | Node type | Reactome Root | Reactome Root Name |
---|---|---|---|---|
R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | Leaf | R-HSA-392499 | Metabolism of proteins |
R-HSA-156902 | Peptide chain elongation | Leaf | R-HSA-392499 | Metabolism of proteins |
R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | Leaf | R-HSA-392499 | Metabolism of proteins |
R-HSA-192823 | Viral mRNA Translation | Leaf | R-HSA-1643685 | Disease |
R-HSA-2408557 | Selenocysteine synthesis | Leaf | R-HSA-1430728 | Metabolism |
R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | Leaf | R-HSA-8953854 | Metabolism of RNA |
R-HSA-72649 | Translation initiation complex formation | Leaf | R-HSA-392499 | Metabolism of proteins |
R-HSA-72689 | Formation of a pool of free 40S subunits | Leaf | R-HSA-392499 | Metabolism of proteins |
R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | Leaf | R-HSA-392499 | Metabolism of proteins |
R-HSA-72702 | Ribosomal scanning and start codon recognition | Leaf | R-HSA-392499 | Metabolism of proteins |
R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | Leaf | R-HSA-392499 | Metabolism of proteins |
R-HSA-72764 | Eukaryotic Translation Termination | Leaf | R-HSA-392499 | Metabolism of proteins |
R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | Leaf | R-HSA-1266738 | Developmental Biology |
R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | Leaf | R-HSA-8953897 | Cellular responses to stimuli |
R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | Leaf | R-HSA-1643685 | Disease |
R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | Leaf | R-HSA-1643685 | Disease |
R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | Leaf | R-HSA-8953854 | Metabolism of RNA |
R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | Leaf | R-HSA-8953854 | Metabolism of RNA |
Location | ECO term | Pubmed |
---|---|---|
Cytoplasm | ECO:0000269 | PubMed:16314389 |
Cytoplasm | ECO:0000269 | PubMed:17289661 |
Cytoplasm | ECO:0000269 | PubMed:17560175 |
Cytoplasm | ECO:0000269 | PubMed:18045535 |
Cytoplasm | ECO:0000269 | PubMed:20217897 |
Cytoplasm | ECO:0000269 | PubMed:21871177 |
Cytoplasm | ECO:0000269 | PubMed:23636399 |
Cytoplasm, cytoskeleton, spindle | ECO:0000269 | PubMed:23131551 |
Mitochondrion inner membrane | ECO:0000269 | PubMed:23911537 |
Nucleus | ECO:0000269 | PubMed:17560175 |
Nucleus | ECO:0000269 | PubMed:18045535 |
Nucleus | ECO:0000269 | PubMed:19460357 |
Nucleus | ECO:0000269 | PubMed:20217897 |
Nucleus | ECO:0000269 | PubMed:21871177 |
Nucleus, nucleolus | ECO:0000269 | PubMed:16314389 |
Nucleus, nucleolus | ECO:0000269 | PubMed:19460357 |