Protein family
Protein sequence
Protein function
Catalytic activity
EC number
EC number description
3.1.3.2
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases;
acid phosphatase
3.1.3.48
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases;
protein-tyrosine-phosphatase
PDB | Resolution (Å) | PDB name |
---|---|---|
1XWW | 1.63 | Crystal Structure of Human B-form Low Molecular Weight Phosphotyrosyl Phosphatase at 1.6 Angstrom Resolution |
3N8I | 1.5 | Crystal structure of the A isoform of human cytoplasmic protein tyrosine phosphatase (HCPTP-A) in complex with 1-naphtylacetic acid |
4Z99 | 2.3 | Crystal structure of the apo Low Molecular Weight Protein Tyrosine Phosphatase isoform A |
4Z9A | 2.1 | Crystal structure of Low Molecular Weight Protein Tyrosine Phosphatase isoform A complexed with phenylmethanesulfonic acid |
4Z9B | 2.41 | Crystal structure of Low Molecular Weight Protein Tyrosine Phosphatase isoform A complexed with benzylphosphonic acid |
5JNR | 2.0 | Crystal structure of human low molecular weight protein tyrosine phosphatase (LMPTP) type A |
5JNS | 1.8 | Crystal structure of human low molecular weight protein tyrosine phosphatase (LMPTP) type A complexed with phosphate |
5JNT | 1.45 | Crystal structure of human low molecular weight protein tyrosine phosphatase (LMPTP) type A complexed with MES |
5KQG | 1.5 | Co-crystal structure of LMW-PTP in complex with 2-(benzothiazol-2-ylamino)-2-oxo-1-phenylethanesulfonic acid |
5KQL | 1.45 | Co-crystal structure of LMW-PTP in complex with 2-oxo-1-phenyl-2-(phenylamino)ethanesulfonic acid |
5KQM | 1.91 | Co-crystal structure of LMW-PTP in complex with MES |
5KQP | 2.052 | Crystal structure of Apo-form LMW-PTP |
5PNT | 2.2 | CRYSTAL STRUCTURE OF A HUMAN LOW MOLECULAR WEIGHT PHOSPHOTYROSYL PHOSPHATASE. IMPLICATIONS FOR SUBSTRATE SPECIFICITY |
6Y2V | 2.0 | Crystal structure of the double mutant L13R I16K of Low Molecular Weight Protein Tyrosine Phosphatase (LMW-PTP) |
6Y2W | 1.77 | Crystal structure of the single mutant I16K of Low Molecular Weight Protein Tyrosine Phosphatase (LMW-PTP) |
7KH8 | 1.3 | Human LMPTP in complex with inhibitor |
7UW6 | 1.5 | The co-crystal structure of low molecular weight protein tyrosine phosphatase (LMW-PTP) with a small molecule inhibitor SPAA-2 |
GO ontology | GO term | GO description |
---|---|---|
Biological Process | GO:0006470 | protein dephosphorylation |
Molecular Function | GO:0003993 | acid phosphatase activity |
Molecular Function | GO:0004726 | non-membrane spanning protein tyrosine phosphatase activity |
Molecular Function | GO:0004725 | protein tyrosine phosphatase activity |
Cellular Component | GO:0005737 | cytoplasm |
Cellular Component | GO:0009898 | cytoplasmic side of plasma membrane |
Cellular Component | GO:0005829 | cytosol |
Cellular Component | GO:0070062 | extracellular exosome |
Cellular Component | GO:0042383 | sarcolemma |
InterPro | InterPro name |
---|---|
IPR002115 | Protein-tyrosine phosphatase, low molecular weight, mammalian |
IPR017867 | Protein-tyrosine phosphatase, low molecular weight |
IPR023485 | Phosphotyrosine protein phosphatase I |
IPR036196 | Phosphotyrosine protein phosphatase I superfamily |
Pfam | Pfam name |
---|---|
PF01451 | Low molecular weight phosphotyrosine protein phosphatase |