Protein family
Protein sequence
Protein function
Catalytic activity
EC number
EC number description
3.1.3.2
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases;
acid phosphatase
3.1.3.48
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases;
protein-tyrosine-phosphatase
| PDB | Resolution (Å) | PDB name |
|---|---|---|
| 1XWW | 1.63 | Crystal Structure of Human B-form Low Molecular Weight Phosphotyrosyl Phosphatase at 1.6 Angstrom Resolution |
| 3N8I | 1.5 | Crystal structure of the A isoform of human cytoplasmic protein tyrosine phosphatase (HCPTP-A) in complex with 1-naphtylacetic acid |
| 4Z99 | 2.3 | Crystal structure of the apo Low Molecular Weight Protein Tyrosine Phosphatase isoform A |
| 4Z9A | 2.1 | Crystal structure of Low Molecular Weight Protein Tyrosine Phosphatase isoform A complexed with phenylmethanesulfonic acid |
| 4Z9B | 2.41 | Crystal structure of Low Molecular Weight Protein Tyrosine Phosphatase isoform A complexed with benzylphosphonic acid |
| 5JNR | 2.0 | Crystal structure of human low molecular weight protein tyrosine phosphatase (LMPTP) type A |
| 5JNS | 1.8 | Crystal structure of human low molecular weight protein tyrosine phosphatase (LMPTP) type A complexed with phosphate |
| 5JNT | 1.45 | Crystal structure of human low molecular weight protein tyrosine phosphatase (LMPTP) type A complexed with MES |
| 5KQG | 1.5 | Co-crystal structure of LMW-PTP in complex with 2-(benzothiazol-2-ylamino)-2-oxo-1-phenylethanesulfonic acid |
| 5KQL | 1.45 | Co-crystal structure of LMW-PTP in complex with 2-oxo-1-phenyl-2-(phenylamino)ethanesulfonic acid |
| 5KQM | 1.91 | Co-crystal structure of LMW-PTP in complex with MES |
| 5KQP | 2.052 | Crystal structure of Apo-form LMW-PTP |
| 5PNT | 2.2 | CRYSTAL STRUCTURE OF A HUMAN LOW MOLECULAR WEIGHT PHOSPHOTYROSYL PHOSPHATASE. IMPLICATIONS FOR SUBSTRATE SPECIFICITY |
| 6Y2V | 2.0 | Crystal structure of the double mutant L13R I16K of Low Molecular Weight Protein Tyrosine Phosphatase (LMW-PTP) |
| 6Y2W | 1.77 | Crystal structure of the single mutant I16K of Low Molecular Weight Protein Tyrosine Phosphatase (LMW-PTP) |
| 7KH8 | 1.3 | Human LMPTP in complex with inhibitor |
| 7UW6 | 1.5 | The co-crystal structure of low molecular weight protein tyrosine phosphatase (LMW-PTP) with a small molecule inhibitor SPAA-2 |
| GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0006470 | protein dephosphorylation |
| Molecular Function | GO:0003993 | acid phosphatase activity |
| Molecular Function | GO:0004726 | non-membrane spanning protein tyrosine phosphatase activity |
| Molecular Function | GO:0004725 | protein tyrosine phosphatase activity |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0009898 | cytoplasmic side of plasma membrane |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0042383 | sarcolemma |
| InterPro
|
InterPro name |
|---|---|
| IPR002115 | Protein-tyrosine phosphatase, low molecular weight, mammalian |
| IPR017867 | Protein-tyrosine phosphatase, low molecular weight |
| IPR023485 | Phosphotyrosine protein phosphatase I |
| IPR036196 | Phosphotyrosine protein phosphatase I superfamily |
| Pfam
|
Pfam name |
|---|---|
| PF01451 | Low molecular weight phosphotyrosine protein phosphatase |