MultifacetedProtDB - Bologna Biocomputing Group

Structure

PDB	Resolution (Å)	PDB name
2F5H		Solution structure of the alpha-domain of human Metallothionein-3
2FJ4		SOLUTION STRUCTURE OF a-domain of HUMAN Metallothionein-3 (MT-3)
2FJ5		SOLUTION STRUCTURE OF sole a-domain of HUMAN Metallothionein-3 (MT-3)

GO term

GO ontology	GO term	GO description
Biological Process	GO:0070371	ERK1 and ERK2 cascade
Biological Process	GO:0032148	activation of protein kinase B activity
Biological Process	GO:0007420	brain development
Biological Process	GO:0071280	cellular response to copper ion
Biological Process	GO:0071456	cellular response to hypoxia
Biological Process	GO:0034599	cellular response to oxidative stress
Biological Process	GO:0034614	cellular response to reactive oxygen species
Biological Process	GO:0006112	energy reserve metabolic process
Biological Process	GO:0030003	intracellular monoatomic cation homeostasis
Biological Process	GO:0006882	intracellular zinc ion homeostasis
Biological Process	GO:0033210	leptin-mediated signaling pathway
Biological Process	GO:0043066	negative regulation of apoptotic process
Biological Process	GO:0030517	negative regulation of axon extension
Biological Process	GO:0030308	negative regulation of cell growth
Biological Process	GO:2000117	negative regulation of cysteine-type endopeptidase activity
Biological Process	GO:2000296	negative regulation of hydrogen peroxide catabolic process
Biological Process	GO:0060547	negative regulation of necrotic cell death
Biological Process	GO:0043524	negative regulation of neuron apoptotic process
Biological Process	GO:0010977	negative regulation of neuron projection development
Biological Process	GO:0051354	negative regulation of oxidoreductase activity
Biological Process	GO:2000378	negative regulation of reactive oxygen species metabolic process
Biological Process	GO:0045893	positive regulation of DNA-templated transcription
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade
Biological Process	GO:0010628	positive regulation of gene expression
Biological Process	GO:0010940	positive regulation of necrotic cell death
Biological Process	GO:2000376	positive regulation of oxygen metabolic process
Biological Process	GO:0001934	positive regulation of protein phosphorylation
Biological Process	GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway
Biological Process	GO:0043491	protein kinase B signaling
Biological Process	GO:0050821	protein stabilization
Biological Process	GO:0032095	regulation of response to food
Biological Process	GO:0019430	removal of superoxide radicals
Biological Process	GO:0001666	response to hypoxia
Biological Process	GO:0006829	zinc ion transport
Molecular Function	GO:0016209	antioxidant activity
Molecular Function	GO:0046870	cadmium ion binding
Molecular Function	GO:0005507	copper ion binding
Molecular Function	GO:0030295	protein kinase activator activity
Molecular Function	GO:0008270	zinc ion binding
Cellular Component	GO:0097450	astrocyte end-foot
Cellular Component	GO:0030424	axon
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0043197	dendritic spine
Cellular Component	GO:0005615	extracellular space
Cellular Component	GO:0016234	inclusion body
Cellular Component	GO:0005874	microtubule
Cellular Component	GO:0005741	mitochondrial outer membrane
Cellular Component	GO:0048471	perinuclear region of cytoplasm
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0014069	postsynaptic density
Cellular Component	GO:0005840	ribosome
Cellular Component	GO:0005791	rough endoplasmic reticulum
Cellular Component	GO:0008021	synaptic vesicle

InterPro	InterPro name
IPR000006	Metallothionein, vertebrate
IPR003019	Metallothionein
IPR017854	Metallothionein domain superfamily
IPR018064	Metallothionein, vertebrate, metal binding site
IPR023587	Metallothionein domain superfamily, vertebrate

Pfam	Pfam name
PF00131	Metallothionein

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-5661231	Metallothioneins bind metals	Leaf	R-HSA-8953897	Cellular responses to stimuli

Phenotype

Tissue and cell type

Tissue	Cell type	Expression level	Reliability
caudate	glial cells	High	Enhanced
caudate	neuronal cells	Medium	Enhanced
cerebellum	granular cells - cytoplasm/membrane	High	Enhanced
cerebellum	granular cells - nucleus	High	Enhanced
cerebellum	molecular layer - neuropil	Medium	Enhanced
cerebellum	molecular layer cells - cytoplasm/membrane	High	Enhanced
cerebellum	molecular layer cells - nucleus	High	Enhanced
cerebellum	processes in granular layer	High	Enhanced
cerebellum	processes in white matter	Medium	Enhanced
cerebellum	synaptic glomeruli - capsule	High	Enhanced
cerebellum	white matter cells - cytoplasm/membrane	High	Enhanced
cerebellum	white matter cells - nucleus	High	Enhanced
cerebral cortex	endothelial cells	Medium	Enhanced
cerebral cortex	glial cells	High	Enhanced
cerebral cortex	neuronal cells	Medium	Enhanced
cerebral cortex	neuropil	Medium	Enhanced
hippocampus	glial cells	High	Enhanced
hippocampus	neuronal cells	Low	Enhanced

Summary of P25713

Gene: MT3
Protein: Metallothionein-3

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of P25713

Gene: MT3 Protein: Metallothionein-3

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: MT3
Protein: Metallothionein-3