Protein family
The protein has not catalytic activity
Protein sequence
Protein function
Publications
Catalytic activity
| PDB | Resolution (Å) | PDB name |
|---|---|---|
| 4J8S | 1.55 | Crystal structure of human CNOT1 MIF4G domain in complex with a TTP peptide |
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0061158 | 3'-UTR-mediated mRNA destabilization |
| Biological Process | GO:0070935 | 3'-UTR-mediated mRNA stabilization |
| Biological Process | GO:0000165 | MAPK cascade |
| Biological Process | GO:0071364 | cellular response to epidermal growth factor stimulus |
| Biological Process | GO:0044344 | cellular response to fibroblast growth factor stimulus |
| Biological Process | GO:0071385 | cellular response to glucocorticoid stimulus |
| Biological Process | GO:0097011 | cellular response to granulocyte macrophage colony-stimulating factor stimulus |
| Biological Process | GO:0071222 | cellular response to lipopolysaccharide |
| Biological Process | GO:0071356 | cellular response to tumor necrosis factor |
| Biological Process | GO:0060218 | hematopoietic stem cell differentiation |
| Biological Process | GO:0006402 | mRNA catabolic process |
| Biological Process | GO:0051028 | mRNA transport |
| Biological Process | GO:0035278 | miRNA-mediated gene silencing by inhibition of translation |
| Biological Process | GO:0030099 | myeloid cell differentiation |
| Biological Process | GO:0045647 | negative regulation of erythrocyte differentiation |
| Biological Process | GO:1902037 | negative regulation of hematopoietic stem cell differentiation |
| Biological Process | GO:0050728 | negative regulation of inflammatory response |
| Biological Process | GO:0032703 | negative regulation of interleukin-2 production |
| Biological Process | GO:1904246 | negative regulation of polynucleotide adenylyltransferase activity |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0032897 | negative regulation of viral transcription |
| Biological Process | GO:0000288 | nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay |
| Biological Process | GO:0031086 | nuclear-transcribed mRNA catabolic process, deadenylation-independent decay |
| Biological Process | GO:0000289 | nuclear-transcribed mRNA poly(A) tail shortening |
| Biological Process | GO:0038066 | p38MAPK cascade |
| Biological Process | GO:1901835 | positive regulation of deadenylation-independent decapping of nuclear-transcribed mRNA |
| Biological Process | GO:0045600 | positive regulation of fat cell differentiation |
| Biological Process | GO:1904582 | positive regulation of intracellular mRNA localization |
| Biological Process | GO:2000637 | positive regulation of miRNA-mediated gene silencing |
| Biological Process | GO:1900153 | positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay |
| Biological Process | GO:0060213 | positive regulation of nuclear-transcribed mRNA poly(A) tail shortening |
| Biological Process | GO:1902172 | regulation of keratinocyte apoptotic process |
| Biological Process | GO:0045616 | regulation of keratinocyte differentiation |
| Biological Process | GO:0010837 | regulation of keratinocyte proliferation |
| Biological Process | GO:0043488 | regulation of mRNA stability |
| Biological Process | GO:0032680 | regulation of tumor necrosis factor production |
| Biological Process | GO:0042594 | response to starvation |
| Biological Process | GO:0009611 | response to wounding |
| Molecular Function | GO:0071889 | 14-3-3 protein binding |
| Molecular Function | GO:0019957 | C-C chemokine binding |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0070063 | RNA polymerase binding |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0031072 | heat shock protein binding |
| Molecular Function | GO:0035925 | mRNA 3'-UTR AU-rich region binding |
| Molecular Function | GO:0003729 | mRNA binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Cellular Component | GO:0030014 | CCR4-NOT complex |
| Cellular Component | GO:0000932 | P-body |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0010494 | cytoplasmic stress granule |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:1990904 | ribonucleoprotein complex |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | Leaf | R-HSA-8953854 | Metabolism of RNA |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Cytoplasm | ECO:0000269 | PubMed:10330172 |
| Cytoplasm | ECO:0000269 | PubMed:12115244 |
| Cytoplasm | ECO:0000269 | PubMed:14679154 |
| Cytoplasm | ECO:0000269 | PubMed:14766228 |
| Cytoplasm | ECO:0000269 | PubMed:15014438 |
| Cytoplasm | ECO:0000269 | PubMed:20221403 |
| Cytoplasm, P-body | ECO:0000269 | PubMed:17369404 |
| Cytoplasmic granule | ECO:0000269 | PubMed:15014438 |
| Nucleus | ECO:0000269 | PubMed:14679154 |
| Nucleus | ECO:0000269 | PubMed:15014438 |
| Nucleus | ECO:0000269 | PubMed:27182009 |
| HPO ID
|
HPO name |
|---|
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adipose tissue | adipocytes | Low | Approved |
| adrenal gland | glandular cells | Medium | Approved |
| appendix | glandular cells | Medium | Approved |
| appendix | lymphoid tissue | Low | Approved |
| breast | glandular cells | Medium | Approved |
| breast | myoepithelial cells | Medium | Approved |
| bronchus | respiratory epithelial cells | High | Approved |
| caudate | glial cells | Low | Approved |
| caudate | neuronal cells | High | Approved |
| cerebellum | Purkinje cells | High | Approved |
| cerebellum | cells in granular layer | Low | Approved |
| cerebellum | cells in molecular layer | Medium | Approved |
| cerebral cortex | endothelial cells | Low | Approved |
| cerebral cortex | glial cells | Low | Approved |
| cerebral cortex | neuronal cells | High | Approved |
| cervix | squamous epithelial cells | High | Approved |
| colon | endothelial cells | Medium | Approved |
| colon | glandular cells | Low | Approved |
| colon | peripheral nerve/ganglion | Low | Approved |
| duodenum | glandular cells | Low | Approved |
| endometrium 1 | cells in endometrial stroma | Low | Approved |
| endometrium 1 | glandular cells | Low | Approved |
| endometrium 2 | cells in endometrial stroma | Low | Approved |
| endometrium 2 | glandular cells | Low | Approved |
| epididymis | glandular cells | Low | Approved |
| esophagus | squamous epithelial cells | High | Approved |
| fallopian tube | glandular cells | Low | Approved |
| gallbladder | glandular cells | Low | Approved |
| hippocampus | glial cells | Low | Approved |
| hippocampus | neuronal cells | Medium | Approved |
| kidney | cells in glomeruli | Low | Approved |
| liver | cholangiocytes | Low | Approved |
| lung | alveolar cells | Low | Approved |
| lung | macrophages | Medium | Approved |
| lymph node | germinal center cells | Low | Approved |
| lymph node | non-germinal center cells | Medium | Approved |
| nasopharynx | respiratory epithelial cells | High | Approved |
| oral mucosa | squamous epithelial cells | High | Approved |
| ovary | follicle cells | Low | Approved |
| ovary | ovarian stroma cells | Low | Approved |
| pancreas | pancreatic endocrine cells | Medium | Approved |
| parathyroid gland | glandular cells | Low | Approved |
| placenta | decidual cells | Medium | Approved |
| placenta | trophoblastic cells | Low | Approved |
| prostate | glandular cells | Medium | Approved |
| rectum | glandular cells | High | Approved |
| salivary gland | glandular cells | Medium | Approved |
| seminal vesicle | glandular cells | High | Approved |
| skeletal muscle | myocytes | Medium | Approved |
| skin 1 | Langerhans | High | Approved |
| skin 1 | keratinocytes | High | Approved |
| skin 1 | melanocytes | High | Approved |
| soft tissue 1 | peripheral nerve | Low | Approved |
| spleen | cells in red pulp | Low | Approved |
| spleen | cells in white pulp | Low | Approved |
| stomach 1 | glandular cells | Medium | Approved |
| stomach 2 | glandular cells | Medium | Approved |
| testis | Leydig cells | Medium | Approved |
| thyroid gland | glandular cells | Medium | Approved |
| tonsil | germinal center cells | Low | Approved |
| tonsil | non-germinal center cells | Low | Approved |
| tonsil | squamous epithelial cells | High | Approved |
| urinary bladder | urothelial cells | Medium | Approved |
| vagina | squamous epithelial cells | High | Approved |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|