Protein family
Protein sequence
Protein function
Catalytic activity
EC number
EC number description
2.7.4.10
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with a phosphate group as acceptor;
nucleoside-triphosphate—adenylate kinase
2.7.4.6
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with a phosphate group as acceptor;
nucleoside-diphosphate kinase
| GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0006172 | ADP biosynthetic process |
| Biological Process | GO:0046033 | AMP metabolic process |
| Biological Process | GO:0046034 | ATP metabolic process |
| Biological Process | GO:0046039 | GTP metabolic process |
| Biological Process | GO:0071456 | cellular response to hypoxia |
| Biological Process | GO:0015949 | nucleobase-containing small molecule interconversion |
| Biological Process | GO:0009142 | nucleoside triphosphate biosynthetic process |
| Biological Process | GO:0016310 | phosphorylation |
| Biological Process | GO:0002082 | regulation of oxidative phosphorylation |
| Biological Process | GO:0009188 | ribonucleoside diphosphate biosynthetic process |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0005525 | GTP binding |
| Molecular Function | GO:0004017 | adenylate kinase activity |
| Molecular Function | GO:0004550 | nucleoside diphosphate kinase activity |
| Molecular Function | GO:0050145 | nucleoside monophosphate kinase activity |
| Molecular Function | GO:0046899 | nucleoside triphosphate adenylate kinase activity |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| InterPro
|
InterPro name |
|---|---|
| IPR000850 | Adenylate kinase/UMP-CMP kinase |
| IPR006259 | Adenylate kinase subfamily |
| IPR007862 | Adenylate kinase, active site lid domain |
| IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| IPR028585 | Adenylate kinase 4, mitochondrial |
| IPR028586 | Adenylate kinase 3/4, mitochondrial |
| IPR033690 | Adenylate kinase, conserved site |
| IPR036193 | Adenylate kinase, active site lid domain superfamily |
| Pfam
|
Pfam name |
|---|---|
| PF00406 | Adenylate kinase |
| PF05191 | Adenylate kinase, active site lid |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-499943 | Interconversion of nucleotide di- and triphosphates | Leaf | R-HSA-1430728 | Metabolism |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Mitochondrion matrix | ECO:0000255 | PubMed:11485571 |
| Mitochondrion matrix | ECO:0000255 | PubMed:19766732 |
| Mitochondrion matrix | ECO:0000255 | PubMed:26980435 |