MultifacetedProtDB - Bologna Biocomputing Group

EC number	EC number description
3.1.1.2	Hydrolases; Acting on ester bonds; Carboxylic-ester hydrolases; arylesterase
3.1.1.81	Hydrolases; Acting on ester bonds; Carboxylic-ester hydrolases; quorum-quenching N-acyl-homoserine lactonase
3.1.8.1	Hydrolases; Acting on ester bonds; Phosphoric-triester hydrolases; aryldialkylphosphatase

Structure

PDB	Resolution (Å)	PDB name
1V04	2.2	serum paraoxonase by directed evolution

GO term

GO ontology	GO term	GO description
Biological Process	GO:0019439	aromatic compound catabolic process
Biological Process	GO:0046395	carboxylic acid catabolic process
Biological Process	GO:0008203	cholesterol metabolic process
Biological Process	GO:0046434	organophosphate catabolic process
Biological Process	GO:0046470	phosphatidylcholine metabolic process
Biological Process	GO:0051099	positive regulation of binding
Biological Process	GO:0010875	positive regulation of cholesterol efflux
Biological Process	GO:0032411	positive regulation of transporter activity
Biological Process	GO:0070542	response to fatty acid
Biological Process	GO:1902617	response to fluoride
Biological Process	GO:0032496	response to lipopolysaccharide
Biological Process	GO:0031667	response to nutrient levels
Biological Process	GO:0009636	response to toxic substance
Molecular Function	GO:0102007	acyl-L-homoserine-lactone lactonohydrolase activity
Molecular Function	GO:0004063	aryldialkylphosphatase activity
Molecular Function	GO:0004064	arylesterase activity
Molecular Function	GO:0005509	calcium ion binding
Molecular Function	GO:0005543	phospholipid binding
Molecular Function	GO:0042803	protein homodimerization activity
Cellular Component	GO:0072562	blood microparticle
Cellular Component	GO:0005789	endoplasmic reticulum membrane
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0005576	extracellular region
Cellular Component	GO:0005615	extracellular space
Cellular Component	GO:0034364	high-density lipoprotein particle
Cellular Component	GO:0034366	spherical high-density lipoprotein particle

InterPro / Pfam

InterPro	InterPro name
IPR002640	Arylesterase
IPR008363	Paraoxonase1
IPR011042	Six-bladed beta-propeller, TolB-like

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-2142688	Synthesis of 5-eicosatetraenoic acids	Leaf	R-HSA-1430728	Metabolism
R-HSA-9754706	Atorvastatin ADME	Leaf	R-HSA-9748784	Drug ADME

HPO ID	HPO name
HP:0000217	Xerostomia
HP:0000712	Emotional lability
HP:0000713	Agitation
HP:0000716	Depression
HP:0000739	Anxiety
HP:0001257	Spasticity
HP:0002017	Nausea and vomiting
HP:0002094	Dyspnea
HP:0002180	Neurodegeneration
HP:0002795	Abnormal respiratory system physiology
HP:0002878	Respiratory failure
HP:0003202	Skeletal muscle atrophy
HP:0003324	Generalized muscle weakness
HP:0003394	Muscle spasm
HP:0003470	Paralysis
HP:0007354	Amyotrophic lateral sclerosis
HP:0007373	Motor neuron atrophy
HP:0012378	Fatigue
HP:0012531	Pain
HP:0025425	Laryngospasm
HP:0030192	Fatigable weakness of bulbar muscles
HP:0030195	Fatigable weakness of swallowing muscles
HP:0030196	Fatigable weakness of respiratory muscles

Disease name	MONDO ID	ICD10	ICD10 chapter	OMIM	Orphanet
amyotrophic lateral sclerosis	MONDO:0004976	G12	chapter6, Diseases of the nervous system		Orphanet:803
microvascular complications of diabetes- susceptibility to- 5	MONDO:0012969	-	-	OMIM:612633

Summary of P27169

Gene: PON1, PON
Protein: Serum paraoxonase/arylesterase 1

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of P27169

Gene: PON1, PON Protein: Serum paraoxonase/arylesterase 1

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: PON1, PON
Protein: Serum paraoxonase/arylesterase 1