MultifacetedProtDB - Bologna Biocomputing Group

Structure

PDB	Resolution (Å)	PDB name
2BTP	2.8	14-3-3 Protein Theta (Human) Complexed to Peptide
5IQP	2.602	14-3-3 PROTEIN TAU ISOFORM
6BCR	1.986	Complex of 14-3-3 theta with an IRSp53 peptide phosphorylated at T340
6BD2	2.9	Complex of 14-3-3 theta with an IRSp53 peptide doubly-phosphorylated at T340 and S366
6BQT	2.8	Complex of 14-3-3 theta with an IRSp53 peptide doubly-phosphorylated at T340 and T360
6KZG	2.0	14-3-3 protein in Complex with CIC S301 phosphorylated peptide
6KZH	2.645	14-3-3 protein in Complex with CIC S173 phosphorylated peptide

GO term

GO ontology	GO term	GO description
Biological Process	GO:0045892	negative regulation of DNA-templated transcription
Biological Process	GO:0034766	negative regulation of monoatomic ion transmembrane transport
Biological Process	GO:0006605	protein targeting
Biological Process	GO:0007165	signal transduction
Biological Process	GO:0007264	small GTPase mediated signal transduction
Biological Process	GO:0021762	substantia nigra development
Molecular Function	GO:0071889	14-3-3 protein binding
Molecular Function	GO:0042802	identical protein binding
Molecular Function	GO:0019904	protein domain specific binding
Molecular Function	GO:0044325	transmembrane transporter binding
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0005925	focal adhesion
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0032991	protein-containing complex
Cellular Component	GO:0045202	synapse

InterPro / Pfam

InterPro	InterPro name
IPR000308	14-3-3 protein
IPR023409	14-3-3 protein, conserved site
IPR023410	14-3-3 domain
IPR036815	14-3-3 domain superfamily
IPR042584	14-3-3 theta

Pfam	Pfam name
PF00244	14-3-3 protein

Reactome

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-111447	Activation of BAD and translocation to mitochondria	Leaf	R-HSA-5357801	Programmed Cell Death
R-HSA-1445148	Translocation of SLC2A4 (GLUT4) to the plasma membrane	Leaf	R-HSA-5653656	Vesicle-mediated transport
R-HSA-5625740	RHO GTPases activate PKNs	Internal node	R-HSA-162582	Signal Transduction
R-HSA-5628897	TP53 Regulates Metabolic Genes	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-75035	Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-9614399	Regulation of localization of FOXO transcription factors	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-9735871	SARS-CoV-1 targets host intracellular signalling and regulatory pathways	Leaf	R-HSA-1643685	Disease
R-HSA-9755779	SARS-CoV-2 targets host intracellular signalling and regulatory pathways	Leaf	R-HSA-1643685	Disease

Subcellular location

Location	ECO term	Pubmed
Cytoplasm

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Tissue	Cell type	Expression level	Reliability
adrenal gland	glandular cells	Medium	Approved
appendix	glandular cells	Medium	Approved
breast	glandular cells	Medium	Approved
breast	myoepithelial cells	Medium	Approved
caudate	glial cells	Low	Approved
caudate	neuronal cells	Medium	Approved
cerebellum	Purkinje cells	Medium	Approved
cerebral cortex	glial cells	Medium	Approved
cerebral cortex	neuronal cells	Medium	Approved
cerebral cortex	neuropil	Medium	Approved
cervix	glandular cells	Low	Approved
cervix	squamous epithelial cells	Low	Approved
colon	endothelial cells	Low	Approved
colon	glandular cells	Medium	Approved
colon	peripheral nerve/ganglion	High	Approved
duodenum	glandular cells	Medium	Approved
endometrium 1	cells in endometrial stroma	Low	Approved
endometrium 1	glandular cells	Medium	Approved
endometrium 2	glandular cells	Medium	Approved
epididymis	glandular cells	Medium	Approved
esophagus	squamous epithelial cells	Low	Approved
fallopian tube	glandular cells	Medium	Approved
gallbladder	glandular cells	Low	Approved
hippocampus	neuronal cells	Medium	Approved
kidney	cells in glomeruli	Low	Approved
kidney	cells in tubules	Low	Approved
liver	cholangiocytes	Medium	Approved
lung	alveolar cells	Low	Approved
lymph node	germinal center cells	Medium	Approved
lymph node	non-germinal center cells	Low	Approved
nasopharynx	respiratory epithelial cells	Low	Approved
oral mucosa	squamous epithelial cells	Low	Approved
ovary	ovarian stroma cells	Low	Approved
pancreas	exocrine glandular cells	Medium	Approved
pancreas	pancreatic endocrine cells	Medium	Approved
parathyroid gland	glandular cells	Medium	Approved
placenta	trophoblastic cells	Medium	Approved
prostate	glandular cells	Medium	Approved
rectum	glandular cells	Medium	Approved
salivary gland	glandular cells	Medium	Approved
seminal vesicle	glandular cells	Low	Approved
skin 1	fibroblasts	Medium	Approved
skin 1	keratinocytes	Low	Approved
skin 1	melanocytes	Low	Approved
skin 2	epidermal cells	Low	Approved
small intestine	glandular cells	Low	Approved
soft tissue 1	chondrocytes	Medium	Approved
soft tissue 1	fibroblasts	Low	Approved
spleen	cells in red pulp	Low	Approved
stomach 1	glandular cells	Low	Approved
stomach 2	glandular cells	Low	Approved
testis	Leydig cells	Low	Approved
testis	cells in seminiferous ducts	Medium	Approved
thyroid gland	glandular cells	Low	Approved
tonsil	germinal center cells	Low	Approved
tonsil	non-germinal center cells	Low	Approved
tonsil	squamous epithelial cells	Medium	Approved
urinary bladder	urothelial cells	Low	Approved
vagina	squamous epithelial cells	Low	Approved

Summary of P27348

Gene: YWHAQ
Protein: 14-3-3 protein theta

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of P27348

Gene: YWHAQ Protein: 14-3-3 protein theta

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: YWHAQ
Protein: 14-3-3 protein theta