MultifacetedProtDB - Bologna Biocomputing Group

Structure

PDB	Resolution (Å)	PDB name
2PA2	2.5	Crystal structure of human Ribosomal protein L10 core domain
5AJ0	3.5	Cryo electron microscopy of actively translating human polysomes (POST state).
6OLE	3.1	Human ribosome nascent chain complex (CDH1-RNC) stalled by a drug-like molecule with AP and PE tRNAs
6OLF	3.9	Human ribosome nascent chain complex (CDH1-RNC) stalled by a drug-like molecule with AA and PE tRNAs
6OLG	3.4	Human ribosome nascent chain complex stalled by a drug-like small molecule (CDH1_RNC with PP tRNA)
6OLI	3.5	Structure of human ribosome nascent chain complex selectively stalled by a drug-like small molecule (USO1-RNC)
6OLZ	3.9	Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like molecule with PP tRNA
6OM0	3.1	Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like molecule with AP and PE tRNAs
6OM7	3.7	Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like small molecule with AA and PE tRNAs
6W6L	3.84	Cryo-EM structure of the human ribosome-TMCO1 translocon
7F5S	2.72	human delta-METTL18 60S ribosome
8A3D	1.67	Human mature large subunit of the ribosome with eIF6 and homoharringtonine bound

GO term

GO ontology	GO term	GO description
Biological Process	GO:0002181	cytoplasmic translation
Biological Process	GO:1990403	embryonic brain development
Biological Process	GO:0043066	negative regulation of apoptotic process
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II
Biological Process	GO:0006417	regulation of translation
Biological Process	GO:0000027	ribosomal large subunit assembly
Biological Process	GO:0006412	translation
Molecular Function	GO:0003723	RNA binding
Molecular Function	GO:0003735	structural constituent of ribosome
Molecular Function	GO:0045182	translation regulator activity
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0022625	cytosolic large ribosomal subunit
Cellular Component	GO:0022626	cytosolic ribosome
Cellular Component	GO:0005783	endoplasmic reticulum
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0032991	protein-containing complex

InterPro / Pfam

InterPro	InterPro name
IPR001197	Ribosomal protein L10e
IPR016180	Ribosomal protein L10e/L16
IPR018255	Ribosomal protein L10e, conserved site
IPR036920	Ribosomal protein L10e/L16 superfamily

Pfam	Pfam name
PF00252	Ribosomal protein L16p/L10e

Reactome

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-156827	L13a-mediated translational silencing of Ceruloplasmin expression	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-156902	Peptide chain elongation	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-1799339	SRP-dependent cotranslational protein targeting to membrane	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-192823	Viral mRNA Translation	Leaf	R-HSA-1643685	Disease
R-HSA-2408557	Selenocysteine synthesis	Leaf	R-HSA-1430728	Metabolism
R-HSA-6791226	Major pathway of rRNA processing in the nucleolus and cytosol	Leaf	R-HSA-8953854	Metabolism of RNA
R-HSA-72689	Formation of a pool of free 40S subunits	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-72706	GTP hydrolysis and joining of the 60S ribosomal subunit	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-72764	Eukaryotic Translation Termination	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-9010553	Regulation of expression of SLITs and ROBOs	Leaf	R-HSA-1266738	Developmental Biology
R-HSA-9633012	Response of EIF2AK4 (GCN2) to amino acid deficiency	Leaf	R-HSA-8953897	Cellular responses to stimuli
R-HSA-975956	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	Leaf	R-HSA-8953854	Metabolism of RNA
R-HSA-975957	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Leaf	R-HSA-8953854	Metabolism of RNA

Subcellular location

Location	ECO term	Pubmed
Cytoplasm	ECO:0000250

Interactor | Variant | Drug

Phenotype

HPO ID	HPO name
HP:0000023	Inguinal hernia
HP:0000028	Cryptorchidism
HP:0000047	Hypospadias
HP:0000160	Narrow mouth
HP:0000219	Thin upper lip vermilion
HP:0000232	Everted lower lip vermilion
HP:0000252	Microcephaly
HP:0000268	Dolichocephaly
HP:0000276	Long face
HP:0000286	Epicanthus
HP:0000303	Mandibular prognathia
HP:0000308	Microretrognathia
HP:0000319	Smooth philtrum
HP:0000337	Broad forehead
HP:0000343	Long philtrum
HP:0000365	Hearing impairment
HP:0000369	Low-set ears
HP:0000400	Macrotia
HP:0000407	Sensorineural hearing impairment
HP:0000411	Protruding ear
HP:0000431	Wide nasal bridge
HP:0000510	Rod-cone dystrophy
HP:0000540	Hypermetropia
HP:0000545	Myopia
HP:0000577	Exotropia
HP:0000678	Dental crowding
HP:0000717	Autism
HP:0000750	Delayed speech and language development
HP:0000823	Delayed puberty
HP:0000939	Osteoporosis
HP:0000954	Single transverse palmar crease
HP:0000960	Sacral dimple
HP:0001007	Hirsutism
HP:0001182	Tapered finger
HP:0001249	Intellectual disability
HP:0001250	Seizure
HP:0001251	Ataxia
HP:0001252	Hypotonia
HP:0001263	Global developmental delay
HP:0001290	Generalized hypotonia
HP:0001319	Neonatal hypotonia
HP:0001321	Cerebellar hypoplasia
HP:0001337	Tremor
HP:0001344	Absent speech
HP:0001419	X-linked recessive inheritance
HP:0001510	Growth delay
HP:0001511	Intrauterine growth retardation
HP:0001561	Polyhydramnios
HP:0001601	Laryngomalacia
HP:0001622	Premature birth
HP:0001629	Ventricular septal defect
HP:0001631	Atrial septal defect
HP:0001769	Broad foot
HP:0001770	Toe syndactyly
HP:0001999	Abnormal facial shape
HP:0002020	Gastroesophageal reflux
HP:0002066	Gait ataxia
HP:0002069	Bilateral tonic-clonic seizure
HP:0002359	Frequent falls
HP:0002373	Febrile seizure (within the age range of 3 months to 6 years)
HP:0002540	Inability to walk
HP:0002650	Scoliosis
HP:0002655	Spondyloepiphyseal dysplasia
HP:0002719	Recurrent infections
HP:0003577	Congenital onset
HP:0004209	Clinodactyly of the 5th finger
HP:0004322	Short stature
HP:0004415	Pulmonary artery stenosis
HP:0004626	Lumbar scoliosis
HP:0005709	2-3 toe cutaneous syndactyly
HP:0005750	Lower-limb joint contracture
HP:0006101	Finger syndactyly
HP:0006380	Knee flexion contracture
HP:0006466	Ankle flexion contracture
HP:0006698	Dilatation of the ventricular cavity
HP:0007359	Focal-onset seizure
HP:0008689	Bilateral cryptorchidism
HP:0008734	Decreased testicular size
HP:0008850	Severe postnatal growth retardation
HP:0008872	Feeding difficulties in infancy
HP:0008947	Infantile muscular hypotonia
HP:0009381	Short finger
HP:0009540	Contracture of the proximal interphalangeal joint of the 2nd finger
HP:0009796	Branchial cyst
HP:0010621	Cutaneous syndactyly of toes
HP:0010818	Generalized tonic seizure
HP:0010864	Intellectual disability, severe
HP:0011003	High myopia
HP:0011234	Absent antihelix
HP:0011461	Fetal onset
HP:0011787	Central hypothyroidism
HP:0012032	Lipoma
HP:0012033	Sacral lipoma
HP:0012385	Camptodactyly
HP:0012520	Dilation of Virchow-Robin spaces
HP:0012811	Wide nasal ridge
HP:0030891	Periventricular white matter hyperintensities
HP:0031535	Increased theta frequency activity in EEG
HP:0031936	Delayed ability to walk
HP:0034042	Dorsal hirsutism
HP:0040080	Anteverted ears
HP:0045025	Narrow palpebral fissure
HP:0100716	Self-injurious behavior

Tissue and cell type

Tissue	Cell type	Expression level	Reliability
adipose tissue	adipocytes	Medium	Enhanced
adrenal gland	glandular cells	High	Enhanced
appendix	endocrine cells	High	Enhanced
appendix	enterocytes	High	Enhanced
appendix	germinal center cells	Medium	Enhanced
appendix	goblet cells	High	Enhanced
appendix	non-germinal center cells	Medium	Enhanced
bone marrow	hematopoietic cells	High	Enhanced
breast	adipocytes	Low	Enhanced
breast	glandular cells	High	Enhanced
breast	myoepithelial cells	High	Enhanced
bronchus	respiratory epithelial cells	High	Enhanced
caudate	glial cells	Medium	Enhanced
caudate	neuronal cells	High	Enhanced
cerebellum	Bergmann glia - cytoplasm/membrane	Medium	Enhanced
cerebellum	GLUC cells - cytoplasm/membrane	High	Enhanced
cerebellum	Purkinje cells - cytoplasm/membrane	High	Enhanced
cerebellum	Purkinje cells - dendrites	Medium	Enhanced
cerebellum	granular cells - cytoplasm/membrane	Medium	Enhanced
cerebellum	molecular layer cells - cytoplasm/membrane	High	Enhanced
cerebellum	white matter cells - cytoplasm/membrane	Medium	Enhanced
cerebral cortex	endothelial cells	Medium	Enhanced
cerebral cortex	glial cells	High	Enhanced
cerebral cortex	neuronal cells	High	Enhanced
cerebral cortex	neuropil	Low	Enhanced
cervix	glandular cells	High	Enhanced
cervix	squamous epithelial cells	High	Enhanced
colon	endocrine cells	High	Enhanced
colon	endothelial cells	High	Enhanced
colon	enterocytes	High	Enhanced
colon	fibroblasts	High	Enhanced
colon	goblet cells	High	Enhanced
colon	mucosal lymphoid cells	High	Enhanced
colon	peripheral nerve/ganglion	High	Enhanced
duodenum	endocrine cells	High	Enhanced
duodenum	enterocytes	High	Enhanced
duodenum	glands of Brunner	High	Enhanced
duodenum	goblet cells	High	Enhanced
duodenum	paneth cells	High	Enhanced
endometrium 1	cells in endometrial stroma	Medium	Enhanced
endometrium 1	glandular cells	High	Enhanced
endometrium 2	cells in endometrial stroma	Medium	Enhanced
endometrium 2	glandular cells	High	Enhanced
epididymis	glandular cells	High	Enhanced
esophagus	squamous epithelial cells	High	Enhanced
fallopian tube	glandular cells	High	Enhanced
gallbladder	glandular cells	High	Enhanced
heart muscle	cardiomyocytes	Medium	Enhanced
hippocampus	glial cells	Medium	Enhanced
hippocampus	neuronal cells	High	Enhanced
kidney	cells in glomeruli	Medium	Enhanced
kidney	cells in tubules	High	Enhanced
liver	cholangiocytes	Medium	Enhanced
liver	hepatocytes	High	Enhanced
lung	alveolar cells	High	Enhanced
lung	macrophages	High	Enhanced
lymph node	germinal center cells	High	Enhanced
lymph node	non-germinal center cells	High	Enhanced
nasopharynx	respiratory epithelial cells	High	Enhanced
oral mucosa	squamous epithelial cells	High	Enhanced
ovary	follicle cells	Medium	Enhanced
ovary	ovarian stroma cells	High	Enhanced
pancreas	exocrine glandular cells	High	Enhanced
pancreas	pancreatic endocrine cells	Medium	Enhanced
parathyroid gland	glandular cells	High	Enhanced
placenta	cytotrophoblasts	High	Enhanced
placenta	decidual cells	High	Enhanced
placenta	endothelial cells	High	Enhanced
placenta	hofbauer cells	High	Enhanced
placenta	syncytiotrophoblasts - cell body	High	Enhanced
placenta	syncytiotrophoblasts - microvilli	High	Enhanced
prostate	glandular cells	High	Enhanced
rectum	endocrine cells	High	Enhanced
rectum	endothelial cells	Medium	Enhanced
rectum	enterocytes	High	Enhanced
rectum	goblet cells	High	Enhanced
rectum	mucosal lymphoid cells	High	Enhanced
salivary gland	glandular cells	High	Enhanced
seminal vesicle	glandular cells	High	Enhanced
skeletal muscle	myocytes	Medium	Enhanced
skin 1	cells in basal layer	Medium	Enhanced
skin 1	cells in granular layer	Medium	Enhanced
skin 1	cells in spinous layer	Medium	Enhanced
skin 1	endothelial cells	Medium	Enhanced
skin 1	fibrohistiocytic cells	Medium	Enhanced
skin 1	langerhans cells	Medium	Enhanced
skin 1	lymphocytes	Low	Enhanced
skin 1	melanocytes	Medium	Enhanced
skin 1	sebaceous glands	Medium	Enhanced
skin 2	arrector pili muscle cells	Low	Enhanced
skin 2	cells in basal layer	High	Enhanced
skin 2	cells in granular layer	High	Enhanced
skin 2	cells in spinous layer	High	Enhanced
skin 2	endothelial cells	Medium	Enhanced
skin 2	fibrohistiocytic cells	High	Enhanced
skin 2	hair follicles	High	Enhanced
skin 2	langerhans cells	High	Enhanced
skin 2	lymphocytes	Low	Enhanced
skin 2	melanocytes	High	Enhanced
small intestine	endocrine cells	High	Enhanced
small intestine	enterocytes	High	Enhanced
small intestine	goblet cells	Medium	Enhanced
smooth muscle	smooth muscle cells	Medium	Enhanced
soft tissue 1	fibroblasts	Medium	Enhanced
soft tissue 1	peripheral nerve	Low	Enhanced
soft tissue 2	fibroblasts	Medium	Enhanced
soft tissue 2	peripheral nerve	Low	Enhanced
spleen	cells in red pulp	Medium	Enhanced
spleen	cells in white pulp	High	Enhanced
stomach 1	glandular cells	High	Enhanced
stomach 2	glandular cells	High	Enhanced
testis	Leydig cells	High	Enhanced
testis	sertoli cells	Low	Enhanced
testis	spermatogonia cells	Medium	Enhanced
thyroid gland	glandular cells	High	Enhanced
tonsil	germinal center cells	High	Enhanced
tonsil	non-germinal center cells	High	Enhanced
tonsil	squamous epithelial cells	High	Enhanced
urinary bladder	urothelial cells	High	Enhanced
vagina	squamous epithelial cells	High	Enhanced

Disease

Disease name	MONDO ID	ICD10	ICD10 chapter	OMIM	Orphanet
autism- susceptibility to- x-linked 5	MONDO:0010449	F84	chapter5, Mental and behavioural disorders	OMIM:300847
x-linked microcephaly-growth retardation-prognathism-cryptorchidism syndrome	MONDO:0018569	Q87	chapter17, Congenital malformations, deformations and chromosomal abnormalities		Orphanet:435938
x-linked intellectual disability-cerebellar hypoplasia-spondylo-epiphyseal dysplasia syndrome	MONDO:0018724	Q77	chapter17, Congenital malformations, deformations and chromosomal abnormalities		Orphanet:459070
intellectual disability, x-linked, syndromic, 35	MONDO:0030908	F70	chapter5, Mental and behavioural disorders	OMIM:300998	Orphanet:435938
intellectual disability, x-linked, syndromic, 35	MONDO:0030908	F70	chapter5, Mental and behavioural disorders	OMIM:300998	Orphanet:459070

Summary of P27635

Gene: RPL10, DXS648E, QM
Protein: Large ribosomal subunit protein uL16

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of P27635

Gene: RPL10, DXS648E, QM Protein: Large ribosomal subunit protein uL16

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: RPL10, DXS648E, QM
Protein: Large ribosomal subunit protein uL16