MultifacetedProtDB - Bologna Biocomputing Group

Structure

PDB	Resolution (Å)	PDB name
2CLR	2.0	THREE DIMENSIONAL STRUCTURE OF A PEPTIDE EXTENDING OUT ONE END OF A CLASS I MHC BINDING SITE
3DOW	2.3	Complex structure of GABA type A receptor associated protein and its binding epitope on calreticulin
3POS	1.65	Crystal structure of the globular domain of human calreticulin
3POW	1.55	Crystal structure of the globular domain of human calreticulin
5LK5	2.3	Crystal structure of the globular domain of human calreticulin mutant D71K
5V90	3.255	Crystal structure of ERp29 D-domain in complex with the P-domain of calreticulin
6ENY	5.8	Structure of the human PLC editing module
7QPD	3.73	Structure of the human MHC I peptide-loading complex editing module

GO term

GO ontology	GO term	GO description
Biological Process	GO:0055007	cardiac muscle cell differentiation
Biological Process	GO:0071257	cellular response to electrical stimulus
Biological Process	GO:0071285	cellular response to lithium ion
Biological Process	GO:0098586	cellular response to virus
Biological Process	GO:0090398	cellular senescence
Biological Process	GO:0030866	cortical actin cytoskeleton organization
Biological Process	GO:0042921	glucocorticoid receptor signaling pathway
Biological Process	GO:0006874	intracellular calcium ion homeostasis
Biological Process	GO:0045892	negative regulation of DNA-templated transcription
Biological Process	GO:0033144	negative regulation of intracellular steroid hormone receptor signaling pathway
Biological Process	GO:0045665	negative regulation of neuron differentiation
Biological Process	GO:0048387	negative regulation of retinoic acid receptor signaling pathway
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II
Biological Process	GO:0017148	negative regulation of translation
Biological Process	GO:1901164	negative regulation of trophoblast cell migration
Biological Process	GO:0002502	peptide antigen assembly with MHC class I protein complex
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling
Biological Process	GO:0045787	positive regulation of cell cycle
Biological Process	GO:0008284	positive regulation of cell population proliferation
Biological Process	GO:2000510	positive regulation of dendritic cell chemotaxis
Biological Process	GO:0010595	positive regulation of endothelial cell migration
Biological Process	GO:0010628	positive regulation of gene expression
Biological Process	GO:0050766	positive regulation of phagocytosis
Biological Process	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading
Biological Process	GO:0006611	protein export from nucleus
Biological Process	GO:0006457	protein folding
Biological Process	GO:0034975	protein folding in endoplasmic reticulum
Biological Process	GO:0034504	protein localization to nucleus
Biological Process	GO:0022417	protein maturation by protein folding
Biological Process	GO:0050821	protein stabilization
Biological Process	GO:0006355	regulation of DNA-templated transcription
Biological Process	GO:0042981	regulation of apoptotic process
Biological Process	GO:0040020	regulation of meiotic nuclear division
Biological Process	GO:0032355	response to estradiol
Biological Process	GO:1903416	response to glycoside
Biological Process	GO:0033574	response to testosterone
Biological Process	GO:0009410	response to xenobiotic stimulus
Biological Process	GO:0061912	selective autophagy
Biological Process	GO:0051208	sequestering of calcium ion
Biological Process	GO:0007283	spermatogenesis
Biological Process	GO:0030433	ubiquitin-dependent ERAD pathway
Molecular Function	GO:0003677	DNA binding
Molecular Function	GO:0003723	RNA binding
Molecular Function	GO:0005509	calcium ion binding
Molecular Function	GO:0030246	carbohydrate binding
Molecular Function	GO:0001849	complement component C1q complex binding
Molecular Function	GO:0042562	hormone binding
Molecular Function	GO:0005178	integrin binding
Molecular Function	GO:0005506	iron ion binding
Molecular Function	GO:0003729	mRNA binding
Molecular Function	GO:0050681	nuclear androgen receptor binding
Molecular Function	GO:0005049	nuclear export signal receptor activity
Molecular Function	GO:0042277	peptide binding
Molecular Function	GO:0044183	protein folding chaperone
Molecular Function	GO:0051087	protein-folding chaperone binding
Molecular Function	GO:0031625	ubiquitin protein ligase binding
Molecular Function	GO:0051082	unfolded protein binding
Molecular Function	GO:0008270	zinc ion binding
Cellular Component	GO:0005794	Golgi apparatus
Cellular Component	GO:0042824	MHC class I peptide loading complex
Cellular Component	GO:0001669	acrosomal vesicle
Cellular Component	GO:0009986	cell surface
Cellular Component	GO:0062023	collagen-containing extracellular matrix
Cellular Component	GO:0060473	cortical granule
Cellular Component	GO:0044194	cytolytic granule
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0071682	endocytic vesicle lumen
Cellular Component	GO:0005783	endoplasmic reticulum
Cellular Component	GO:0005788	endoplasmic reticulum lumen
Cellular Component	GO:0005789	endoplasmic reticulum membrane
Cellular Component	GO:0044322	endoplasmic reticulum quality control compartment
Cellular Component	GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane
Cellular Component	GO:0009897	external side of plasma membrane
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0005576	extracellular region
Cellular Component	GO:0005615	extracellular space
Cellular Component	GO:0005925	focal adhesion
Cellular Component	GO:0098553	lumenal side of endoplasmic reticulum membrane
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0005635	nuclear envelope
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0048471	perinuclear region of cytoplasm
Cellular Component	GO:0030670	phagocytic vesicle membrane
Cellular Component	GO:0005844	polysome
Cellular Component	GO:0033018	sarcoplasmic reticulum lumen
Cellular Component	GO:0005790	smooth endoplasmic reticulum

InterPro / Pfam

InterPro	InterPro name
IPR001580	Calreticulin/calnexin
IPR009033	Calreticulin/calnexin, P domain superfamily
IPR009169	Calreticulin
IPR013320	Concanavalin A-like lectin/glucanase domain superfamily
IPR018124	Calreticulin/calnexin, conserved site

Pfam	Pfam name
PF00262	Calreticulin family

Reactome

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-1236974	ER-Phagosome pathway	Leaf	R-HSA-168256	Immune System
R-HSA-168316	Assembly of Viral Components at the Budding Site	Internal node	R-HSA-1643685	Disease
R-HSA-3000480	Scavenging by Class A Receptors	Leaf	R-HSA-5653656	Vesicle-mediated transport
R-HSA-3000484	Scavenging by Class F Receptors	Leaf	R-HSA-5653656	Vesicle-mediated transport
R-HSA-381183	ATF6 (ATF6-alpha) activates chaperone genes	Leaf	R-HSA-8953897	Cellular responses to stimuli
R-HSA-901042	Calnexin/calreticulin cycle	Internal node	R-HSA-392499	Metabolism of proteins
R-HSA-983170	Antigen Presentation: Folding, assembly and peptide loading of class I MHC	Leaf	R-HSA-168256	Immune System

Subcellular location

Location	ECO term	Pubmed
Cell surface	ECO:0000269	PubMed:10358038
Cytolytic granule	ECO:0000269	PubMed:8418194
Cytoplasm, cytosol	ECO:0000269	PubMed:11149926
Cytoplasmic vesicle, secretory vesicle, Cortical granule	ECO:0000250
Endoplasmic reticulum lumen	ECO:0000269	PubMed:10358038
Endoplasmic reticulum lumen	ECO:0000269	PubMed:11149926
Sarcoplasmic reticulum lumen	ECO:0000250
Secreted, extracellular space, extracellular matrix	ECO:0000305

Interactor | Variant | Drug

Phenotype

HPO ID	HPO name
HP:0000006	Autosomal dominant inheritance
HP:0000952	Jaundice
HP:0000967	Petechiae
HP:0000979	Purpura
HP:0000980	Pallor
HP:0001028	Hemangioma
HP:0001082	Cholecystitis
HP:0001394	Cirrhosis
HP:0001409	Portal hypertension
HP:0001428	Somatic mutation
HP:0001433	Hepatosplenomegaly
HP:0001541	Ascites
HP:0001658	Myocardial infarction
HP:0001744	Splenomegaly
HP:0001824	Weight loss
HP:0001871	Abnormality of blood and blood-forming tissues
HP:0001872	Abnormality of thrombocytes
HP:0001873	Thrombocytopenia
HP:0001876	Pancytopenia
HP:0001892	Abnormal bleeding
HP:0001894	Thrombocytosis
HP:0001903	Anemia
HP:0001945	Fever
HP:0001974	Leukocytosis
HP:0001977	Abnormal thrombosis
HP:0001978	Extramedullary hematopoiesis
HP:0002024	Malabsorption
HP:0002027	Abdominal pain
HP:0002039	Anorexia
HP:0002040	Esophageal varix
HP:0002239	Gastrointestinal hemorrhage
HP:0002240	Hepatomegaly
HP:0002326	Transient ischemic attack
HP:0002488	Acute leukemia
HP:0002586	Peritonitis
HP:0002716	Lymphadenopathy
HP:0002863	Myelodysplasia
HP:0002910	Elevated hepatic transaminase
HP:0003010	Prolonged bleeding time
HP:0003388	Easy fatigability
HP:0003401	Paresthesia
HP:0004326	Cachexia
HP:0004377	Hematological neoplasm
HP:0004420	Arterial thrombosis
HP:0004447	Poikilocytosis
HP:0004866	Impaired ADP-induced platelet aggregation
HP:0004936	Venous thrombosis
HP:0005214	Intestinal obstruction
HP:0005244	Gastrointestinal infarctions
HP:0005513	Increased megakaryocyte count
HP:0005547	Myeloproliferative disorder
HP:0005561	Abnormality of bone marrow cell morphology
HP:0006554	Acute hepatic failure
HP:0008148	Impaired epinephrine-induced platelet aggregation
HP:0008320	Impaired collagen-induced platelet aggregation
HP:0011134	Low-grade fever
HP:0011875	Abnormal platelet morphology
HP:0011974	Myelofibrosis
HP:0012143	Abnormal megakaryocyte morphology
HP:0012156	Hemophagocytosis
HP:0012378	Fatigue
HP:0025142	Constitutional symptom
HP:0025435	Increased circulating lactate dehydrogenase concentration
HP:0030057	Autoimmune antibody positivity
HP:0030157	Flank pain
HP:0031020	Bone marrow hypercellularity
HP:0031364	Ecchymosis
HP:0100576	Amaurosis fugax
HP:0100659	Abnormal cerebral vascular morphology
HP:0100749	Chest pain

Tissue and cell type

Tissue	Cell type	Expression level	Reliability
appendix	glandular cells	Low	Enhanced
bone marrow	hematopoietic cells	Medium	Enhanced
breast	glandular cells	Low	Enhanced
breast	myoepithelial cells	Low	Enhanced
bronchus	respiratory epithelial cells	Low	Enhanced
caudate	neuronal cells	Low	Enhanced
cerebellum	Purkinje cells	Medium	Enhanced
cerebellum	cells in molecular layer	Low	Enhanced
cerebral cortex	neuronal cells	Medium	Enhanced
cervix	glandular cells	Low	Enhanced
cervix	squamous epithelial cells	Low	Enhanced
duodenum	glandular cells	Low	Enhanced
endometrium 1	cells in endometrial stroma	Medium	Enhanced
endometrium 1	glandular cells	Low	Enhanced
endometrium 2	glandular cells	Low	Enhanced
epididymis	glandular cells	Medium	Enhanced
fallopian tube	glandular cells	Low	Enhanced
gallbladder	glandular cells	Medium	Enhanced
hippocampus	neuronal cells	Medium	Enhanced
liver	cholangiocytes	Low	Enhanced
liver	hepatocytes	Low	Enhanced
lung	alveolar cells type II	Medium	Enhanced
lung	macrophages	Medium	Enhanced
lymph node	non-germinal center cells	Low	Enhanced
nasopharynx	respiratory epithelial cells	Low	Enhanced
pancreas	exocrine glandular cells	Medium	Enhanced
parathyroid gland	glandular cells	Low	Enhanced
placenta	decidual cells	Medium	Enhanced
placenta	trophoblastic cells	Medium	Enhanced
prostate	glandular cells	Medium	Enhanced
rectum	glandular cells	Low	Enhanced
seminal vesicle	glandular cells	Low	Enhanced
skin 1	fibrohistiocytic cells	Low	Enhanced
skin 2	fibrohistiocytic cells	Medium	Enhanced
skin 2	lymphocytes	Low	Enhanced
small intestine	glandular cells	Low	Enhanced
spleen	cells in red pulp	Low	Enhanced
stomach 1	glandular cells	Medium	Enhanced
stomach 2	glandular cells	Low	Enhanced
testis	Leydig cells	Medium	Enhanced
testis	sertoli cells	Low	Enhanced
thyroid gland	glandular cells	High	Enhanced
tonsil	non-germinal center cells	Low	Enhanced
tonsil	squamous epithelial cells	Low	Enhanced
urinary bladder	urothelial cells	Low	Enhanced

Disease name	MONDO ID	ICD10	ICD10 chapter	OMIM	Orphanet
essential thrombocythemia	MONDO:0005029	D47	chapter2, Neoplasms		Orphanet:3318
essential thrombocythemia	MONDO:0005029	D47	chapter2, Neoplasms		Orphanet:71493
thrombocythemia 1	MONDO:0008554	D75	chapter3, Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	OMIM:187950	Orphanet:71493
primary myelofibrosis	MONDO:0009692	D47	chapter2, Neoplasms	OMIM:254450	Orphanet:824
primary myelofibrosis	MONDO:0009692	D75	chapter3, Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	OMIM:254450	Orphanet:824

Summary of P27797

Gene: CALR, CRTC
Protein: Calreticulin

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of P27797

Gene: CALR, CRTC Protein: Calreticulin

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: CALR, CRTC
Protein: Calreticulin