Protein family
Protein sequence
Protein function
Catalytic activity
EC number
EC number description
2.5.1.18
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date);
glutathione transferase
| PDB | Resolution (Å) | PDB name |
|---|---|---|
| 1HNA | 1.85 | CRYSTAL STRUCTURE OF HUMAN CLASS MU GLUTATHIONE TRANSFERASE GSTM2-2: EFFECTS OF LATTICE PACKING ON CONFORMATIONAL HETEROGENEITY |
| 1HNB | 3.5 | CRYSTAL STRUCTURE OF HUMAN CLASS MU GLUTATHIONE TRANSFERASE GSTM2-2: EFFECTS OF LATTICE PACKING ON CONFORMATIONAL HETEROGENEITY |
| 1HNC | 3.0 | CRYSTAL STRUCTURE OF HUMAN CLASS MU GLUTATHIONE TRANSFERASE GSTM2-2: EFFECTS OF LATTICE PACKING ON CONFORMATIONAL HETEROGENEITY |
| 1XW5 | 1.8 | Human glutathione s-transferase M2-2 (E.C.2.5.1.18)complexed with glutathione, monoclinic crystal form |
| 1YKC | 2.1 | human glutathione S-transferase m2-2 (E.C.2.5.1.18) complexed with glutathione-disulfide |
| 2AB6 | 2.5 | HUMAN GLUTATHIONE S-TRANSFERASE M2-2 (E.C.2.5.1.18) complexed with S-METHYLGLUTATHIONE |
| 2C4J | 1.35 | Human glutathione-S-transferase M2-2 T210S mutant in complex with glutathione-styrene oxide conjugate |
| 2GTU | 2.55 | LIGAND-FREE HUMAN GLUTATHIONE S-TRANSFERASE M2-2 (E.C.2.5.1.18), MONOCLINIC CRYSTAL FORM |
| 3GTU | 2.8 | LIGAND-FREE HETERODIMERIC HUMAN GLUTATHIONE S-TRANSFERASE M2-3 (EC 2.5.1.18), MONOCLINIC CRYSTAL FORM |
| 3GUR | 2.5 | Crystal Structure of mu class glutathione S-transferase (GSTM2-2) in complex with glutathione and 6-(7-Nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) |
| 5HWL | 1.6 | Human glutathione s-transferase Mu2 complexed with BDEA, monoclinic crystal form |
| GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0070458 | cellular detoxification of nitrogen compound |
| Biological Process | GO:0071313 | cellular response to caffeine |
| Biological Process | GO:0006749 | glutathione metabolic process |
| Biological Process | GO:0051122 | hepoxilin biosynthetic process |
| Biological Process | GO:0043651 | linoleic acid metabolic process |
| Biological Process | GO:0060315 | negative regulation of ryanodine-sensitive calcium-release channel activity |
| Biological Process | GO:0018916 | nitrobenzene metabolic process |
| Biological Process | GO:0060316 | positive regulation of ryanodine-sensitive calcium-release channel activity |
| Biological Process | GO:0010881 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion |
| Biological Process | GO:0010880 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum |
| Biological Process | GO:0014809 | regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion |
| Biological Process | GO:0055119 | relaxation of cardiac muscle |
| Biological Process | GO:0042178 | xenobiotic catabolic process |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0005504 | fatty acid binding |
| Molecular Function | GO:0043295 | glutathione binding |
| Molecular Function | GO:0004602 | glutathione peroxidase activity |
| Molecular Function | GO:0004364 | glutathione transferase activity |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0005102 | signaling receptor binding |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0045171 | intercellular bridge |
| Cellular Component | GO:0016529 | sarcoplasmic reticulum |
| InterPro
|
InterPro name |
|---|---|
| IPR003081 | Glutathione S-transferase, Mu class |
| IPR004045 | Glutathione S-transferase, N-terminal |
| IPR004046 | Glutathione S-transferase, C-terminal |
| IPR010987 | Glutathione S-transferase, C-terminal-like |
| IPR036249 | Thioredoxin-like superfamily |
| IPR036282 | Glutathione S-transferase, C-terminal domain superfamily |
| IPR040079 | Glutathione transferase family |
| Pfam
|
Pfam name |
|---|---|
| PF00043 | Glutathione S-transferase, C-terminal domain |
| PF02798 | Glutathione S-transferase, N-terminal domain |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-156590 | Glutathione conjugation | Internal node | R-HSA-1430728 | Metabolism |