Protein family
Protein sequence
Protein function
Publications
Catalytic activity
EC number
EC number description
3.4.11.1
Hydrolases;
Acting on peptide bonds (peptidases);
Aminopeptidases;
leucyl aminopeptidase
3.4.11.5
Hydrolases;
Acting on peptide bonds (peptidases);
Aminopeptidases;
prolyl aminopeptidase
3.4.13.23
Hydrolases;
Acting on peptide bonds (peptidases);
Dipeptidases;
cysteinylglycine-S-conjugate dipeptidase
| PDB | Resolution (Å) | PDB name |
|---|
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0006508 | proteolysis |
| Molecular Function | GO:0004177 | aminopeptidase activity |
| Molecular Function | GO:0004180 | carboxypeptidase activity |
| Molecular Function | GO:0030145 | manganese ion binding |
| Molecular Function | GO:0070006 | metalloaminopeptidase activity |
| Molecular Function | GO:0008235 | metalloexopeptidase activity |
| Molecular Function | GO:0008233 | peptidase activity |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0005634 | nucleus |
| InterPro
|
InterPro name |
|---|---|
| IPR000819 | Peptidase M17, leucyl aminopeptidase, C-terminal |
| IPR008283 | Peptidase M17, leucyl aminopeptidase, N-terminal |
| IPR011356 | Peptidase M17, leucine aminopeptidase/peptidase B |
| IPR023042 | Peptidase M17, leucine aminopeptidase |
| IPR043472 | Macro domain-like |
| Pfam
|
Pfam name |
|---|---|
| PF00883 | Cytosol aminopeptidase family, catalytic domain |
| PF02789 | Cytosol aminopeptidase family, N-terminal domain |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Cytoplasm | ECO:0000250 |
| HPO ID
|
HPO name |
|---|
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adipose tissue | adipocytes | Low | Enhanced |
| adrenal gland | glandular cells | Medium | Enhanced |
| appendix | glandular cells | Medium | Enhanced |
| appendix | lymphoid tissue | Medium | Enhanced |
| bone marrow | hematopoietic cells | Low | Enhanced |
| breast | adipocytes | Low | Enhanced |
| breast | glandular cells | Medium | Enhanced |
| breast | myoepithelial cells | Medium | Enhanced |
| bronchus | respiratory epithelial cells | Medium | Enhanced |
| cerebral cortex | endothelial cells | Medium | Enhanced |
| cervix | glandular cells | Low | Enhanced |
| colon | endothelial cells | Medium | Enhanced |
| colon | glandular cells | Medium | Enhanced |
| duodenum | glandular cells | Medium | Enhanced |
| endometrium 1 | cells in endometrial stroma | Low | Enhanced |
| endometrium 1 | glandular cells | Medium | Enhanced |
| endometrium 2 | glandular cells | Low | Enhanced |
| epididymis | glandular cells | Medium | Enhanced |
| esophagus | squamous epithelial cells | Low | Enhanced |
| fallopian tube | glandular cells | Medium | Enhanced |
| gallbladder | glandular cells | Medium | Enhanced |
| kidney | bowman's capsule | Medium | Enhanced |
| kidney | cells in glomeruli | Low | Enhanced |
| kidney | collecting ducts | Low | Enhanced |
| kidney | distal tubules | Low | Enhanced |
| kidney | proximal tubules (cell body) | Medium | Enhanced |
| kidney | proximal tubules (microvilli) | High | Enhanced |
| liver | cholangiocytes | Low | Enhanced |
| liver | hepatocytes | High | Enhanced |
| lung | endothelial cells | High | Enhanced |
| lung | macrophages | Low | Enhanced |
| lymph node | germinal center cells | Medium | Enhanced |
| lymph node | non-germinal center cells | Low | Enhanced |
| nasopharynx | respiratory epithelial cells | Medium | Enhanced |
| oral mucosa | squamous epithelial cells | Low | Enhanced |
| ovary | ovarian stroma cells | Low | Enhanced |
| pancreas | exocrine glandular cells | Medium | Enhanced |
| pancreas | pancreatic endocrine cells | Low | Enhanced |
| parathyroid gland | glandular cells | Medium | Enhanced |
| placenta | decidual cells | Low | Enhanced |
| prostate | glandular cells | Medium | Enhanced |
| rectum | glandular cells | Medium | Enhanced |
| salivary gland | glandular cells | Medium | Enhanced |
| seminal vesicle | glandular cells | Medium | Enhanced |
| skin 1 | cells in basal layer | Low | Enhanced |
| skin 1 | endothelial cells | Medium | Enhanced |
| skin 1 | fibrohistiocytic cells | Medium | Enhanced |
| skin 2 | cells in basal layer | Low | Enhanced |
| skin 2 | endothelial cells | Medium | Enhanced |
| skin 2 | fibrohistiocytic cells | Medium | Enhanced |
| small intestine | glandular cells | Medium | Enhanced |
| soft tissue 1 | chondrocytes | Medium | Enhanced |
| stomach 1 | glandular cells | High | Enhanced |
| stomach 2 | glandular cells | Medium | Enhanced |
| testis | Leydig cells | Low | Enhanced |
| testis | elongated or late spermatids | High | Enhanced |
| testis | pachytene spermatocytes | High | Enhanced |
| testis | round or early spermatids | High | Enhanced |
| testis | sertoli cells | Medium | Enhanced |
| thyroid gland | glandular cells | Medium | Enhanced |
| tonsil | germinal center cells | Medium | Enhanced |
| tonsil | non-germinal center cells | Medium | Enhanced |
| tonsil | squamous epithelial cells | Medium | Enhanced |
| urinary bladder | urothelial cells | Medium | Enhanced |
| vagina | squamous epithelial cells | Low | Enhanced |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|