Protein family
Protein sequence
Protein function
Catalytic activity
EC number
EC number description
2.4.99.20
Transferases;
Glycosyltransferases;
Transferring other glycosyl groups;
2′-phospho-ADP-ribosyl cyclase/2′-phospho-cyclic-ADP-ribose transferase
3.2.2.-
Hydrolases;
Glycosylases;
Hydrolysing N-glycosyl compounds;
3.2.2.6
Hydrolases;
Glycosylases;
Hydrolysing N-glycosyl compounds;
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
PDB | Resolution (Å) | PDB name |
---|---|---|
1YH3 | 1.91 | Crystal structure of human CD38 extracellular domain |
1ZVM | 2.2 | Crystal structure of human CD38: cyclic-ADP-ribosyl synthetase/NAD+ glycohydrolase |
2EF1 | 2.4 | Crystal structure of the extracellular domain of human CD38 |
2HCT | 1.95 | Acidic residues at the active sites of CD38 and ADP-ribosyl cyclase determine NAAPD synthesis and hydrolysis activities |
2I65 | 1.9 | Structural Basis for the Mechanistic Understanding Human CD38 Controlled Multiple Catalysis |
2I66 | 1.7 | Structural Basis for the Mechanistic Understanding Human CD38 Controlled Multiple Catalysis |
2I67 | 1.71 | Structural Basis for the Mechanistic Understanding Human CD38 Controlled Multiple Catalysis |
2O3Q | 1.98 | Structural Basis for Formation and Hydrolysis of Calcium Messenger Cyclic ADP-ribose by Human CD38 |
2O3R | 1.75 | Structural Basis for Formation and Hydrolysis of Calcium Messenger Cyclic ADP-ribose by Human CD38 |
2O3S | 1.5 | Structural Basis for Formation and Hydrolysis of Calcium Messenger Cyclic ADP-ribose by Human CD38 |
2O3T | 1.68 | Structural Basis for Formation and Hydrolysis of Calcium Messenger Cyclic ADP-ribose by Human CD38 |
2O3U | 2.11 | Structural Basis for Formation and Hydrolysis of Calcium Messenger Cyclic ADP-ribose by Human CD38 |
2PGJ | 1.71 | Catalysis associated conformational changes revealed by human cd38 complexed with a non-hydrolyzable substrate analog |
2PGL | 1.76 | Catalysis associated conformational changes revealed by human CD38 complexed with a non-hydrolyzable substrate analog |
3DZF | 2.01 | Crystal structure of human CD38 extracellular domain complexed with a covalent intermediate, ara-F-ribose-5'-phosphate |
3DZG | 1.65 | Crystal structure of human CD38 extracellular domain, ara-F-ribose-5'-phosphate/nicotinamide complex |
3DZH | 1.6 | Crystal structure of human CD38 extracellular domain, GTP complex |
3DZI | 1.73 | Crystal structure of human CD38 extracellular domain, ribose-5'-phosphate intermediate/GTP complex |
3DZJ | 1.9 | Crystal structure of human CD38 extracellular domain E226Q mutant, NMN complex |
3DZK | 1.81 | Crystal structure of human CD38 extracellular domain, NMN complex |
3F6Y | 1.45 | Conformational Closure of the Catalytic Site of Human CD38 Induced by Calcium |
3I9M | 1.75 | Crystal structure of human CD38 complexed with an analog ara-2'F-ADPR |
3I9N | 2.01 | Crystal structure of human CD38 complexed with an analog ribo-2'F-ADP ribose |
3OFS | 2.2 | Dynamic conformations of the CD38-mediated NAD cyclization captured using multi-copy crystallography |
3RAJ | 3.044 | Crystal structure of human CD38 in complex with the Fab fragment of antibody HB7 |
3ROK | 1.65 | Crystal structure of human CD38 in complex with compound CZ-27 |
3ROM | 2.04 | Crystal structure of human CD38 in complex with compound CZ-48 |
3ROP | 1.94 | Crystal structure of human CD38 in complex with compound CZ-50b |
3ROQ | 2.1 | Crystal structure of human CD38 in complex with compound CZ-46 |
3U4H | 1.878 | CD38 structure-based inhibitor design using the N1-cyclic inosine 5'-diphosphate ribose template |
3U4I | 2.118 | CD38 structure-based inhibitor design using the N1-cyclic inosine 5'-diphosphate ribose template |
4CMH | 1.53 | Crystal structure of CD38 with a novel CD38-targeting antibody SAR650984 |
4F45 | 2.1 | Crystal structure of human CD38 E226Q mutant in complex with NAADP |
4F46 | 1.69 | Crystal structure of wild type human CD38 in complex with NAADP and ADPRP |
4OGW | 2.05 | Structure of a human CD38 mutant complexed with NMN |
4TMF | 2.05 | Crystal structure of human CD38 in complex with hydrolysed compound JMS713 |
4XJS | 2.8 | Human CD38 complexed with inhibitor 1 [6-fluoro-2-methyl-4-[(2,3,6-trichlorobenzyl)amino]quinoline-8-carboxamide] |
4XJT | 2.6 | Human CD38 complexed with inhibitor 2 [4-[(2,6-dimethylbenzyl)amino]-2-methylquinoline-8-carboxamide] |
5F1K | 2.3 | human CD38 in complex with nanobody MU1053 |
5F1O | 2.2 | human CD38 in complex with nanobody MU551 |
5F21 | 1.9 | human CD38 in complex with nanobody MU375 |
6EDR | 2.4 | Crystal Structure of Human CD38 in Complex with 4'-Thioribose NAD+ |
6VUA | 1.5 | X-ray structure of human CD38 catalytic domain with 2'-Cl-araNAD+ |
7DHA | 2.55 | crystal structure of CD38 in complex with daratumumab |
7DUO | 2.81 | Crystal structure of daratumumab fab and CD38 complex |
7VKE | 1.9 | Crystal structure of human CD38 ECD in complex with UniDab(TM) F11A |
8D0M | 2.04 | Human CD38 ectodomain bound to a 78c-ADPR adduct |
8IL3 | 3.86 | Cryo-EM structure of CD38 in complex with FTL004 |
GO ontology
|
GO term | GO description |
---|---|---|
Biological Process | GO:0042100 | B cell proliferation |
Biological Process | GO:0050853 | B cell receptor signaling pathway |
Biological Process | GO:0019674 | NAD metabolic process |
Biological Process | GO:0097190 | apoptotic signaling pathway |
Biological Process | GO:0014824 | artery smooth muscle contraction |
Biological Process | GO:0007565 | female pregnancy |
Biological Process | GO:0060292 | long-term synaptic depression |
Biological Process | GO:0045892 | negative regulation of DNA-templated transcription |
Biological Process | GO:0043066 | negative regulation of apoptotic process |
Biological Process | GO:0045779 | negative regulation of bone resorption |
Biological Process | GO:0010977 | negative regulation of neuron projection development |
Biological Process | GO:0030890 | positive regulation of B cell proliferation |
Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
Biological Process | GO:0030307 | positive regulation of cell growth |
Biological Process | GO:0007204 | positive regulation of cytosolic calcium ion concentration |
Biological Process | GO:0032024 | positive regulation of insulin secretion |
Biological Process | GO:0045907 | positive regulation of vasoconstriction |
Biological Process | GO:0032355 | response to estradiol |
Biological Process | GO:0033194 | response to hydroperoxide |
Biological Process | GO:0001666 | response to hypoxia |
Biological Process | GO:0070555 | response to interleukin-1 |
Biological Process | GO:0032570 | response to progesterone |
Biological Process | GO:0032526 | response to retinoic acid |
Biological Process | GO:0009410 | response to xenobiotic stimulus |
Biological Process | GO:0007165 | signal transduction |
Molecular Function | GO:0050135 | NAD(P)+ nucleosidase activity |
Molecular Function | GO:0003953 | NAD+ nucleosidase activity |
Molecular Function | GO:0061809 | NAD+ nucleotidase, cyclic ADP-ribose generating |
Molecular Function | GO:0042802 | identical protein binding |
Molecular Function | GO:0016849 | phosphorus-oxygen lyase activity |
Molecular Function | GO:0016740 | transferase activity |
Cellular Component | GO:0016323 | basolateral plasma membrane |
Cellular Component | GO:0009986 | cell surface |
Cellular Component | GO:0070062 | extracellular exosome |
Cellular Component | GO:0016020 | membrane |
Cellular Component | GO:0005634 | nucleus |
Cellular Component | GO:0005886 | plasma membrane |
Cellular Component | GO:0030667 | secretory granule membrane |
Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
---|---|---|---|---|
R-HSA-196807 | Nicotinate metabolism | Internal node | R-HSA-1430728 | Metabolism |
Location
|
ECO term
|
Pubmed |
---|---|---|
Cell surface | ECO:0000269 | PubMed:2319135 |
Membrane | ECO:0000269 | PubMed:8253715 |