MultifacetedProtDB - Bologna Biocomputing Group

EC number	EC number description
3.1.3.25	Hydrolases; Acting on ester bonds; Phosphoric-monoester hydrolases; inositol-phosphate phosphatase
3.1.3.94	Hydrolases; Acting on ester bonds; Phosphoric-monoester hydrolases; D-galactose 1-phosphate phosphatase

Structure

PDB	Resolution (Å)	PDB name
1AWB	2.5	HUMAN MYO-INOSITOL MONOPHOSPHATASE IN COMPLEX WITH D-INOSITOL-1-PHOSPHATE AND CALCIUM
1IMA	2.3	STRUCTURAL ANALYSIS OF INOSITOL MONOPHOSPHATASE COMPLEXES WITH SUBSTRATES
1IMB	2.2	STRUCTURAL ANALYSIS OF INOSITOL MONOPHOSPHATASE COMPLEXES WITH SUBSTRATES
1IMC	2.6	STRUCTURAL STUDIES OF METAL BINDING BY INOSITOL MONOPHOSPHATASE: EVIDENCE FOR TWO-METAL ION CATALYSIS
1IMD	2.6	STRUCTURAL STUDIES OF METAL BINDING BY INOSITOL MONOPHOSPHATASE: EVIDENCE FOR TWO-METAL ION CATALYSIS
1IME	2.25	STRUCTURAL STUDIES OF METAL BINDING BY INOSITOL MONOPHOSPHATASE: EVIDENCE FOR TWO-METAL ION CATALYSIS
1IMF	2.5	STRUCTURAL STUDIES OF METAL BINDING BY INOSITOL MONOPHOSPHATASE: EVIDENCE FOR TWO-METAL ION CATALYSIS
2HHM	2.1	STRUCTURE OF INOSITOL MONOPHOSPHATASE, THE PUTATIVE TARGET OF LITHIUM THERAPY
4AS4	1.7	Structure of human inositol monophosphatase 1
6GIU	1.39	Human IMPase with L-690330
6GJ0	1.73	Human IMPase with Mn
6ZK0	1.47	1.47A human IMPase with ebselen
7VCE	2.6	Structural studies of human inositol monophosphatase-1 inhibition by ebselen

GO term

GO ontology	GO term	GO description
Biological Process	GO:0006021	inositol biosynthetic process
Biological Process	GO:0006020	inositol metabolic process
Biological Process	GO:0006796	phosphate-containing compound metabolic process
Biological Process	GO:0006661	phosphatidylinositol biosynthetic process
Biological Process	GO:0046854	phosphatidylinositol phosphate biosynthetic process
Biological Process	GO:0007165	signal transduction
Molecular Function	GO:0042802	identical protein binding
Molecular Function	GO:0008934	inositol monophosphate 1-phosphatase activity
Molecular Function	GO:0052832	inositol monophosphate 3-phosphatase activity
Molecular Function	GO:0052833	inositol monophosphate 4-phosphatase activity
Molecular Function	GO:0052834	inositol monophosphate phosphatase activity
Molecular Function	GO:0031403	lithium ion binding
Molecular Function	GO:0000287	magnesium ion binding
Molecular Function	GO:0030145	manganese ion binding
Molecular Function	GO:0042803	protein homodimerization activity
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol

InterPro / Pfam

InterPro	InterPro name
IPR000760	Inositol monophosphatase-like
IPR020550	Inositol monophosphatase, conserved site
IPR020552	Inositol monophosphatase, lithium-sensitive
IPR020583	Inositol monophosphatase, metal-binding site
IPR033942	Inositol monophosphatase

Pfam	Pfam name
PF00459	Inositol monophosphatase family

Reactome

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-1855183	Synthesis of IP2, IP, and Ins in the cytosol	Leaf	R-HSA-1430728	Metabolism

Subcellular location

Location	ECO term	Pubmed
Cytoplasm	ECO:0000269	PubMed:17068342

Interactor | Variant | Drug

Phenotype

HPO ID	HPO name
HP:0000007	Autosomal recessive inheritance
HP:0000718	Aggressive behavior
HP:0001249	Intellectual disability
HP:0011999	Paranoia

Tissue and cell type

Tissue	Cell type	Expression level	Reliability
adipose tissue	adipocytes	Low	Approved
adrenal gland	glandular cells	High	Approved
appendix	glandular cells	Medium	Approved
appendix	lymphoid tissue	Low	Approved
breast	glandular cells	Medium	Approved
bronchus	respiratory epithelial cells	High	Approved
caudate	neuronal cells	Low	Approved
cerebellum	Purkinje cells	Medium	Approved
cerebellum	cells in granular layer	Medium	Approved
cerebellum	cells in molecular layer	Low	Approved
cerebral cortex	endothelial cells	Low	Approved
cerebral cortex	neuronal cells	Low	Approved
cerebral cortex	neuropil	Medium	Approved
cervix	glandular cells	Medium	Approved
colon	endothelial cells	Low	Approved
colon	glandular cells	Medium	Approved
colon	peripheral nerve/ganglion	Low	Approved
duodenum	glandular cells	High	Approved
endometrium 1	glandular cells	Low	Approved
epididymis	glandular cells	Medium	Approved
esophagus	squamous epithelial cells	Medium	Approved
fallopian tube	glandular cells	Medium	Approved
gallbladder	glandular cells	Medium	Approved
heart muscle	cardiomyocytes	Medium	Approved
hippocampus	neuronal cells	Medium	Approved
kidney	cells in tubules	Medium	Approved
liver	hepatocytes	Medium	Approved
lung	alveolar cells	Low	Approved
lung	macrophages	Medium	Approved
lymph node	germinal center cells	Low	Approved
lymph node	non-germinal center cells	Medium	Approved
nasopharynx	respiratory epithelial cells	Medium	Approved
oral mucosa	squamous epithelial cells	Low	Approved
ovary	follicle cells	Low	Approved
pancreas	exocrine glandular cells	Medium	Approved
pancreas	pancreatic endocrine cells	Medium	Approved
parathyroid gland	glandular cells	Medium	Approved
prostate	glandular cells	Low	Approved
rectum	glandular cells	Medium	Approved
salivary gland	glandular cells	Medium	Approved
seminal vesicle	glandular cells	Low	Approved
skeletal muscle	myocytes	Medium	Approved
skin 1	Langerhans	Low	Approved
skin 1	keratinocytes	Low	Approved
skin 1	melanocytes	Low	Approved
skin 2	epidermal cells	Low	Approved
small intestine	glandular cells	Medium	Approved
soft tissue 2	peripheral nerve	Low	Approved
spleen	cells in white pulp	Medium	Approved
stomach 1	glandular cells	Medium	Approved
stomach 2	glandular cells	High	Approved
testis	Leydig cells	Medium	Approved
testis	cells in seminiferous ducts	High	Approved
thyroid gland	glandular cells	High	Approved
tonsil	non-germinal center cells	Low	Approved
urinary bladder	urothelial cells	Medium	Approved
vagina	squamous epithelial cells	Low	Approved

Disease

Disease name	MONDO ID	ICD10	ICD10 chapter	OMIM
intellectual disability- autosomal recessive 59	MONDO:0015020	F70	chapter5, Mental and behavioural disorders	OMIM:617323
intellectual disability- autosomal recessive 59	MONDO:0015020	F71	chapter5, Mental and behavioural disorders	OMIM:617323
intellectual disability- autosomal recessive 59	MONDO:0015020	F72	chapter5, Mental and behavioural disorders	OMIM:617323
intellectual disability- autosomal recessive 59	MONDO:0015020	F73	chapter5, Mental and behavioural disorders	OMIM:617323

Summary of P29218

Gene: IMPA1, IMPA
Protein: Inositol monophosphatase 1

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of P29218

Gene: IMPA1, IMPA Protein: Inositol monophosphatase 1

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: IMPA1, IMPA
Protein: Inositol monophosphatase 1