Protein family
Protein sequence
Protein function
Catalytic activity
EC number
EC number description
1.3.1.24
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor;
biliverdin reductase
1.5.1.30
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor;
flavin reductase (NADPH)
| PDB | Resolution (Å) | PDB name |
|---|---|---|
| 1HDO | 1.15 | Human biliverdin IX beta reductase: NADP complex |
| 1HE2 | 1.2 | Human biliverdin IX beta reductase: NADP/biliverdin IX alpha ternary complex |
| 1HE3 | 1.4 | Human biliverdin IX beta reductase: NADP/mesobiliverdin IV alpha ternary complex |
| 1HE4 | 1.4 | Human biliverdin IX beta reductase: NADP/FMN ternary complex |
| 1HE5 | 1.5 | Human biliverdin IX beta reductase: NADP/Lumichrome ternary complex |
| 5OOG | 1.33 | Human biliverdin IX beta reductase: NADP/Phloxine B ternary complex |
| 5OOH | 1.2 | Human biliverdin IX beta reductase: NADP/Erythrosin extra bluish ternary complex |
| 6OPL | 1.37 | Human biliverdin IX beta reductase Q14R mutant: NADP complex |
| 7ER6 | 1.6 | Crystal structure of human Biliverdin IX-beta reductase B |
| 7ER7 | 1.7 | Crystal structure of hyman Biliverdin IX-beta reductase B with Tamibarotene (A80) |
| 7ER8 | 1.45 | Crystal structure of human Biliverdin IX-beta reductase B with Sulfasalazine (SAS) |
| 7ER9 | 1.45 | Crystal structure of human Biliverdin IX-beta reductase B with Febuxostat (TEI) |
| 7ERA | 1.35 | Crystal structure of human Biliverdin IX-beta reductase B with Olsalazine Sodium (OSS) |
| 7ERB | 1.5 | Crystal structure of human Biliverdin IX-beta reductase B with Ataluren (PTC) |
| 7ERC | 1.5 | Crystal structure of human Biliverdin IX-beta reductase B with Deferasirox (ICL) |
| 7ERD | 2.0 | Crystal structure of human Biliverdin IX-beta reductase B with Flunixin Meglumin (FMG) |
| 7ERE | 1.6 | Crystal structure of human Biliverdin IX-beta reductase B with Pyrantel Pamoate (PPA) |
| GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0042167 | heme catabolic process |
| Molecular Function | GO:0106276 | biliberdin reductase NAD+ activity |
| Molecular Function | GO:0004074 | biliverdin reductase (NAD(P)+) activity |
| Molecular Function | GO:0106277 | biliverdin reductase (NADP+) activity |
| Molecular Function | GO:0042602 | riboflavin reductase (NADPH) activity |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0043231 | intracellular membrane-bounded organelle |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-189483 | Heme degradation | Leaf | R-HSA-1430728 | Metabolism |
| R-HSA-9707564 | Cytoprotection by HMOX1 | Internal node | R-HSA-8953897 | Cellular responses to stimuli |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Cytoplasm | ECO:0000269 | PubMed:7929092 |