Protein family
Protein sequence
Protein function
Publications
Catalytic activity
EC number
EC number description
2.7.4.14
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with a phosphate group as acceptor;
UMP/CMP kinase
2.7.4.6
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with a phosphate group as acceptor;
nucleoside-diphosphate kinase
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0006207 | 'de novo' pyrimidine nucleobase biosynthetic process |
| Biological Process | GO:0046705 | CDP biosynthetic process |
| Biological Process | GO:0006225 | UDP biosynthetic process |
| Biological Process | GO:0015949 | nucleobase-containing small molecule interconversion |
| Biological Process | GO:0016310 | phosphorylation |
| Biological Process | GO:0009220 | pyrimidine ribonucleotide biosynthetic process |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0036430 | CMP kinase activity |
| Molecular Function | GO:0033862 | UMP kinase activity |
| Molecular Function | GO:0004127 | cytidylate kinase activity |
| Molecular Function | GO:0036431 | dCMP kinase activity |
| Molecular Function | GO:0004550 | nucleoside diphosphate kinase activity |
| Molecular Function | GO:0050145 | nucleoside monophosphate kinase activity |
| Molecular Function | GO:0004849 | uridine kinase activity |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-499943 | Interconversion of nucleotide di- and triphosphates | Leaf | R-HSA-1430728 | Metabolism |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Cytoplasm | ECO:0000255 | PubMed:10462544 |
| Cytoplasm | ECO:0000255 | PubMed:11912132 |
| Nucleus | ECO:0000255 | PubMed:10462544 |
| Nucleus | ECO:0000255 | PubMed:11912132 |
| HPO ID
|
HPO name |
|---|
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adrenal gland | glandular cells | Medium | Approved |
| appendix | glandular cells | High | Approved |
| bone marrow | hematopoietic cells | Medium | Approved |
| breast | glandular cells | Medium | Approved |
| breast | myoepithelial cells | Medium | Approved |
| bronchus | respiratory epithelial cells | High | Approved |
| cerebellum | Purkinje cells | Medium | Approved |
| cerebellum | cells in granular layer | Low | Approved |
| cerebral cortex | endothelial cells | Low | Approved |
| cerebral cortex | neuronal cells | Low | Approved |
| cerebral cortex | neuropil | Medium | Approved |
| cervix | glandular cells | Low | Approved |
| cervix | squamous epithelial cells | Medium | Approved |
| colon | endothelial cells | High | Approved |
| colon | glandular cells | High | Approved |
| colon | peripheral nerve/ganglion | High | Approved |
| duodenum | glandular cells | High | Approved |
| endometrium 1 | glandular cells | Medium | Approved |
| endometrium 2 | glandular cells | High | Approved |
| epididymis | glandular cells | Medium | Approved |
| esophagus | squamous epithelial cells | Medium | Approved |
| fallopian tube | glandular cells | Medium | Approved |
| gallbladder | glandular cells | High | Approved |
| heart muscle | cardiomyocytes | High | Approved |
| hippocampus | neuronal cells | Low | Approved |
| kidney | cells in glomeruli | Low | Approved |
| kidney | cells in tubules | Medium | Approved |
| liver | cholangiocytes | Medium | Approved |
| liver | hepatocytes | Medium | Approved |
| lung | alveolar cells type II | High | Approved |
| lung | endothelial cells | Low | Approved |
| lung | macrophages | Medium | Approved |
| lymph node | germinal center cells | Low | Approved |
| lymph node | non-germinal center cells | Medium | Approved |
| nasopharynx | respiratory epithelial cells | High | Approved |
| oral mucosa | squamous epithelial cells | Medium | Approved |
| ovary | follicle cells | High | Approved |
| pancreas | exocrine glandular cells | Medium | Approved |
| pancreas | pancreatic endocrine cells | Medium | Approved |
| parathyroid gland | glandular cells | Medium | Approved |
| placenta | decidual cells | High | Approved |
| placenta | trophoblastic cells | Low | Approved |
| prostate | glandular cells | Medium | Approved |
| rectum | glandular cells | High | Approved |
| salivary gland | glandular cells | High | Approved |
| seminal vesicle | glandular cells | Low | Approved |
| skeletal muscle | myocytes | Medium | Approved |
| skin 1 | Langerhans | Low | Approved |
| skin 1 | fibroblasts | Medium | Approved |
| skin 1 | keratinocytes | Medium | Approved |
| skin 1 | melanocytes | Medium | Approved |
| skin 2 | epidermal cells | Medium | Approved |
| small intestine | glandular cells | High | Approved |
| smooth muscle | smooth muscle cells | Medium | Approved |
| soft tissue 1 | chondrocytes | High | Approved |
| soft tissue 1 | fibroblasts | Low | Approved |
| soft tissue 2 | fibroblasts | Medium | Approved |
| spleen | cells in red pulp | Medium | Approved |
| stomach 1 | glandular cells | Medium | Approved |
| stomach 2 | glandular cells | High | Approved |
| testis | Leydig cells | Medium | Approved |
| testis | cells in seminiferous ducts | Medium | Approved |
| thyroid gland | glandular cells | Medium | Approved |
| tonsil | germinal center cells | Medium | Approved |
| tonsil | non-germinal center cells | Medium | Approved |
| tonsil | squamous epithelial cells | Medium | Approved |
| urinary bladder | urothelial cells | Medium | Approved |
| vagina | squamous epithelial cells | High | Approved |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|