Protein family
Protein sequence
Protein function
Catalytic activity
EC number
EC number description
2.3.1.-
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups;
2.3.1.97
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups;
glycylpeptide N-tetradecanoyltransferase
| PDB | Resolution (Å) | PDB name |
|---|---|---|
| 1RXT | 3.0 | Crystal structure of human myristoyl-CoA:protein N-myristoyltransferase. |
| 3IU1 | 1.42 | Crystal Structure of human type-I N-myristoyltransferase with bound myristoyl-CoA |
| 3IU2 | 1.73 | Crystal Structure of human type-I N-myristoyltransferase with bound myristoyl-CoA and inhibitor DDD90096 |
| 3IWE | 1.79 | Crystal Structure of human type-I N-myristoyltransferase with bound myristoyl-CoA and inhibitor DDD85646 |
| 3JTK | 1.61 | Crystal Structure of human type-I N-myristoyltransferase with bound myristoyl-CoA and inhibitor DDD90055 |
| 4C2Y | 1.64 | Human N-myristoyltransferase (NMT1) with Myristoyl-CoA co-factor |
| 4C2Z | 2.08 | Human N-myristoyltransferase (NMT1) with Myristoyl-CoA and inhibitor bound |
| 5MU6 | 1.88 | Human N-myristoyltransferase (NMT1) with Myristoyl-CoA and IMP-1088 inhibitor bound |
| 5NPQ | 2.372 | Human N-myristoyltransferase 1 (MNT1) with Myristoyl-CoA analogue X10 bound |
| 5O6H | 1.29 | Human NMT1 in complex with myristoyl-CoA and inhibitor IMP-917 |
| 5O6J | 1.45 | Human NMT1 in complex with myristoyl-CoA and inhibitor IMP-1031 |
| 5O9S | 2.7 | HsNMT1 in complex with CoA and Myristoylated-GKSNSKLK octapeptide |
| 5O9T | 2.15 | HsNMT1 in complex with CoA and acetylated-NCFSKPK peptide |
| 5O9U | 1.85 | HsNMT1 in complex with CoA and Myristoylated-GCSVSKKK octapeptide |
| 5O9V | 2.201 | HsNMT1 in complex with CoA and Myristoylated-GGCFSKPK octapeptide |
| 5UUT | 2.252 | N-myristoyltransferase 1 (NMT) bound to myristoyl-CoA |
| 6EHJ | 2.1 | Human N-myristoyltransferase (NMT1) with Myristoyl-CoA and peptide bound |
| 6F56 | 1.9402 | Mutant of Human N-myristoyltransferase with bound myristoyl-CoA |
| 6FZ2 | 2.05 | Human N-myristoyltransferase (NMT1) with Myristoyl-CoA and inhibitor bound |
| 6FZ3 | 2.0 | Human N-myristoyltransferase (NMT1) with Myristoyl-CoA and inhibitor bound |
| 6FZ5 | 1.89 | Human N-myristoyltransferase (NMT1) with Myristoyl-CoA and inhibitor bound |
| 6PAV | 2.52 | Structure of Human NMT1 with products CoA and myristoyl-lysine peptide with acetylated N-terminus |
| 6QRM | 2.3 | HsNMT1 in complex with both MyrCoA and GNCFSKRRAA substrates |
| 6SJZ | 1.995 | HsNMT1 in complex with both MyrCoA and Acetylated-GNCFSKPR substrates |
| 6SK2 | 1.90001 | HsNMT1 in complex with both MyrCoA and Acetylated-GKSFSKPR peptide reveals N-terminal Lysine Myristoylation |
| 6SK3 | 2.7 | C-terminal HsNMT1 deltaC3 truncation in complex with both MyrCoA and GNCFSKPR substrates |
| 6SK8 | 1.87 | DeltaC3 C-terminal truncation of HsNMT1 in complex with MyrCoA and GDCFSKPR substrates |
| 6SKJ | 2.8 | DeltaC2 C-terminal truncation of HsNMT1 in complex with MyrCoA and GNCFSKPR substrates |
| 7OWM | 1.5 | HsNMT1 in complex with both MyrCoA and HCPA substrate peptide GKQNSKLR |
| 7OWN | 2.1 | HsNMT1 in complex with both MyrCoA and peptide AKSFSKPR |
| 7OWO | 1.7 | HsNMT1 in complex with both MyrCoA and N-acetylated KSFSKPR peptide |
| 7OWP | 1.81 | HsNMT1 in complex with both MyrCoA and ACE-G-(L-ORN)SFSKPR |
| 7OWQ | 3.0 | HsNMT1 in complex with both MyrCoA and peptide N-Methylated-GNCFSKPR |
| 7OWR | 2.39 | HsNMT1 in complex with both MyrCoA and peptide GGKSFSKPR |
| 7OWU | 2.08 | HsNMT1 in complex with both CoA and Myr-ANCFSKPR peptide |
| 7RK3 | 2.05 | Crystal structure of human N-myristoyltransferase 1 fragment (residues 109-496) bound to diacylated human Arf6 octapeptide and Coenzyme A |
| GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0018008 | N-terminal peptidyl-glycine N-myristoylation |
| Biological Process | GO:0006499 | N-terminal protein myristoylation |
| Biological Process | GO:0042180 | cellular ketone metabolic process |
| Biological Process | GO:0001701 | in utero embryonic development |
| Biological Process | GO:1900740 | positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway |
| Biological Process | GO:0022400 | regulation of rhodopsin mediated signaling pathway |
| Molecular Function | GO:0004379 | glycylpeptide N-tetradecanoyltransferase activity |
| Molecular Function | GO:0019107 | myristoyltransferase activity |
| Molecular Function | GO:0018030 | peptidyl-lysine N6-myristoyltransferase activity |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005886 | plasma membrane |
| InterPro
|
InterPro name |
|---|---|
| IPR000903 | Glycylpeptide N-tetradecanoyltransferase |
| IPR016181 | Acyl-CoA N-acyltransferase |
| IPR022676 | Glycylpeptide N-tetradecanoyltransferase, N-terminal |
| IPR022677 | Glycylpeptide N-tetradecanoyltransferase, C-terminal |
| IPR022678 | Glycylpeptide N-tetradecanoyltransferase, conserved site |
| Pfam
|
Pfam name |
|---|---|
| PF01233 | Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain |
| PF02799 | Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-162599 | Late Phase of HIV Life Cycle | Internal node | R-HSA-1643685 | Disease |
| R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade | Leaf | R-HSA-9709957 | Sensory Perception |
| R-HSA-75108 | Activation, myristolyation of BID and translocation to mitochondria | Leaf | R-HSA-5357801 | Programmed Cell Death |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Cytoplasm | ECO:0000269 | PubMed:9353336 |
| Cytoplasm | ECO:0000269 | PubMed:9506952 |
| Cytoplasm, cytosol | ECO:0000269 | PubMed:9353336 |
| Membrane | ECO:0000269 | PubMed:9506952 |