MultifacetedProtDB - Bologna Biocomputing Group

Summary of P31939

Gene: ATIC, PURH, OK/SW-cl.86
Protein: Bifunctional purine biosynthesis protein ATIC

Protein family
Protein sequence
Protein function

Catalytic activity

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EC number	EC number description
2.1.2.3	Transferases; Transferring one-carbon groups; Hydroxymethyl-, formyl- and related transferases; phosphoribosylaminoimidazolecarboxamide formyltransferase
3.5.4.10	Hydrolases; Acting on carbon-nitrogen bonds, other than peptide bonds; In cyclic amidines; IMP cyclohydrolase

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Publications

Structure

GO term

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GO ontology	GO term	GO description
Biological Process	GO:0044208	'de novo' AMP biosynthetic process
Biological Process	GO:0006189	'de novo' IMP biosynthetic process
Biological Process	GO:0097294	'de novo' XMP biosynthetic process
Biological Process	GO:0006177	GMP biosynthetic process
Biological Process	GO:0031100	animal organ regeneration
Biological Process	GO:0003360	brainstem development
Biological Process	GO:0098761	cellular response to interleukin-7
Biological Process	GO:0021549	cerebellum development
Biological Process	GO:0021987	cerebral cortex development
Biological Process	GO:0046452	dihydrofolate metabolic process

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InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

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Tissue	Cell type	Expression level	Reliability
adrenal gland	glandular cells	High	Supported
appendix	glandular cells	High	Supported
appendix	lymphoid tissue	High	Supported
bone marrow	hematopoietic cells	High	Supported
breast	glandular cells	High	Supported
breast	myoepithelial cells	High	Supported
bronchus	respiratory epithelial cells	High	Supported
caudate	glial cells	Low	Supported
caudate	neuronal cells	Low	Supported
cerebellum	Bergmann glia - cytoplasm/membrane	Medium	Supported

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Disease