Protein family
The protein has not catalytic activity
Protein sequence
Protein function
Catalytic activity
PDB | Resolution (Å) | PDB name |
---|---|---|
2BQ0 | 2.5 | 14-3-3 Protein Beta (Human) |
2C23 | 2.65 | 14-3-3 Protein Beta (Human) in complex with exoenzyme S peptide |
4DNK | 2.2 | Crystal structure of a tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide (YWHAB) from homo sapiens at 2.20 A resolution. |
5N10 | 1.6 | Cucurbit[8]uril and 14-3-3 based binary bivalent supramolecular-protein assembly platform |
6A5Q | 2.0 | Structure of 14-3-3 beta in complex with TFEB 14-3-3 binding motif |
6BYK | 3.0 | Structure of 14-3-3 beta/alpha bound to O-ClcNAc peptide |
6GN0 | 3.24 | Exoenzyme S from Pseudomonas aeruginosa in complex with human 14-3-3 protein beta, tetrameric crystal form |
6GN8 | 2.34 | Exoenzyme S from Pseudomonas aeruginosa in complex with human 14-3-3 protein beta, trimeric crystal form |
6GNJ | 3.24 | Exoenzyme S from Pseudomonas aeruginosa in complex with human 14-3-3 protein beta, trimeric crystal form in complex with STO1101 |
6GNK | 2.55 | Exoenzyme S from Pseudomonas aeruginosa in complex with human 14-3-3 protein beta, trimeric crystal form bound to Carba-NAD |
6GNN | 3.79 | Exoenzyme T from Pseudomonas aeruginosa in complex with human 14-3-3 protein beta, tetrameric crystal form bound to STO1101 |
6HEP | 1.86 | Crystal structure of human 14-3-3 beta in complex with CFTR R-domain peptide pS753-pS768 |
8EQ8 | 1.5 | The crystal structure of 14-3-3 Beta containing 3-nitrotyrosine at position Y130 |
8EQH | 1.9 | The crystal structure of 14-3-3 Beta containing 3-nitrotyrosine at position Y213 |
GO ontology | GO term | GO description |
---|---|---|
Biological Process | GO:0051220 | cytoplasmic sequestering of protein |
Biological Process | GO:0045744 | negative regulation of G protein-coupled receptor signaling pathway |
Biological Process | GO:0035308 | negative regulation of protein dephosphorylation |
Biological Process | GO:0043085 | positive regulation of catalytic activity |
Biological Process | GO:0006605 | protein targeting |
Biological Process | GO:0007165 | signal transduction |
Molecular Function | GO:0045296 | cadherin binding |
Molecular Function | GO:0019899 | enzyme binding |
Molecular Function | GO:0042826 | histone deacetylase binding |
Molecular Function | GO:0042802 | identical protein binding |
Molecular Function | GO:0051219 | phosphoprotein binding |
Molecular Function | GO:0050815 | phosphoserine residue binding |
Molecular Function | GO:0019904 | protein domain specific binding |
Molecular Function | GO:0004860 | protein kinase inhibitor activity |
Cellular Component | GO:0005737 | cytoplasm |
Cellular Component | GO:0005829 | cytosol |
Cellular Component | GO:0070062 | extracellular exosome |
Cellular Component | GO:0005925 | focal adhesion |
Cellular Component | GO:0042470 | melanosome |
Cellular Component | GO:0016020 | membrane |
Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
Cellular Component | GO:0005774 | vacuolar membrane |
Reactome | Reactome Name | Node type | Reactome Root | Reactome Root Name |
---|---|---|---|---|
R-HSA-111447 | Activation of BAD and translocation to mitochondria | Leaf | R-HSA-5357801 | Programmed Cell Death |
R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | Leaf | R-HSA-5653656 | Vesicle-mediated transport |
R-HSA-165159 | MTOR signalling | Internal node | R-HSA-162582 | Signal Transduction |
R-HSA-166208 | mTORC1-mediated signalling | Leaf | R-HSA-162582 | Signal Transduction |
R-HSA-170968 | Frs2-mediated activation | Leaf | R-HSA-162582 | Signal Transduction |
R-HSA-170984 | ARMS-mediated activation | Leaf | R-HSA-162582 | Signal Transduction |
R-HSA-2028269 | Signaling by Hippo | Leaf | R-HSA-162582 | Signal Transduction |
R-HSA-392517 | Rap1 signalling | Leaf | R-HSA-168256 | Immune System |
R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | Leaf | R-HSA-8953854 | Metabolism of RNA |
R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | Leaf | R-HSA-8953854 | Metabolism of RNA |
R-HSA-5625740 | RHO GTPases activate PKNs | Internal node | R-HSA-162582 | Signal Transduction |
R-HSA-5628897 | TP53 Regulates Metabolic Genes | Leaf | R-HSA-74160 | Gene expression (Transcription) |
R-HSA-5673000 | RAF activation | Leaf | R-HSA-162582 | Signal Transduction |
R-HSA-5674135 | MAP2K and MAPK activation | Leaf | R-HSA-162582 | Signal Transduction |
R-HSA-5675221 | Negative regulation of MAPK pathway | Internal node | R-HSA-162582 | Signal Transduction |
R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | Leaf | R-HSA-1643685 | Disease |
R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | Leaf | R-HSA-1643685 | Disease |
R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | Leaf | R-HSA-1643685 | Disease |
R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | Leaf | R-HSA-1643685 | Disease |
R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | Leaf | R-HSA-1640170 | Cell Cycle |
R-HSA-9614399 | Regulation of localization of FOXO transcription factors | Leaf | R-HSA-74160 | Gene expression (Transcription) |
R-HSA-9649948 | Signaling downstream of RAS mutants | Leaf | R-HSA-1643685 | Disease |
R-HSA-9656223 | Signaling by RAF1 mutants | Leaf | R-HSA-1643685 | Disease |
R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | Leaf | R-HSA-1643685 | Disease |
R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | Leaf | R-HSA-1643685 | Disease |
R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | Leaf | R-HSA-1643685 | Disease |
R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | Leaf | R-HSA-1643685 | Disease |
Location | ECO term | Pubmed |
---|---|---|
Cytoplasm | ECO:0000269 | PubMed:17081065 |
Melanosome | ECO:0000269 | PubMed:17081065 |
Vacuole membrane | ECO:0000269 | PubMed:11260479 |