Protein family
Protein sequence
Protein function
Catalytic activity
EC number
EC number description
6.2.1.15
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases;
arachidonate—CoA ligase
6.2.1.24
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases;
phytanate—CoA ligase
6.2.1.3
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases;
long-chain-fatty-acid—CoA ligase
PDB | Resolution (Å) | PDB name |
---|
GO ontology | GO term | GO description |
---|---|---|
Biological Process | GO:0033211 | adiponectin-activated signaling pathway |
Biological Process | GO:0015908 | fatty acid transport |
Biological Process | GO:0008610 | lipid biosynthetic process |
Biological Process | GO:0044539 | long-chain fatty acid import into cell |
Biological Process | GO:0001676 | long-chain fatty acid metabolic process |
Biological Process | GO:0035338 | long-chain fatty-acyl-CoA biosynthetic process |
Biological Process | GO:0120162 | positive regulation of cold-induced thermogenesis |
Biological Process | GO:0010747 | positive regulation of long-chain fatty acid import across plasma membrane |
Biological Process | GO:0071902 | positive regulation of protein serine/threonine kinase activity |
Biological Process | GO:0007584 | response to nutrient |
Biological Process | GO:0034201 | response to oleic acid |
Biological Process | GO:0014070 | response to organic cyclic compound |
Biological Process | GO:0019432 | triglyceride biosynthetic process |
Biological Process | GO:0000038 | very long-chain fatty acid metabolic process |
Biological Process | GO:0042178 | xenobiotic catabolic process |
Molecular Function | GO:0005524 | ATP binding |
Molecular Function | GO:0047676 | arachidonate-CoA ligase activity |
Molecular Function | GO:0004467 | long-chain fatty acid-CoA ligase activity |
Molecular Function | GO:0090434 | oleoyl-CoA ligase activity |
Molecular Function | GO:0050197 | phytanate-CoA ligase activity |
Molecular Function | GO:0070251 | pristanate-CoA ligase activity |
Cellular Component | GO:0005783 | endoplasmic reticulum |
Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
Cellular Component | GO:0016020 | membrane |
Cellular Component | GO:0005741 | mitochondrial outer membrane |
Cellular Component | GO:0005739 | mitochondrion |
Cellular Component | GO:0005778 | peroxisomal membrane |
Cellular Component | GO:0005886 | plasma membrane |
InterPro | InterPro name |
---|---|
IPR000873 | AMP-dependent synthetase/ligase domain |
IPR020845 | AMP-binding, conserved site |
IPR025110 | AMP-binding enzyme, C-terminal domain |
IPR042099 | ANL, N-terminal domain |
IPR045311 | Long-chain fatty acid CoA synthetase, eukaryotic |
Pfam | Pfam name |
---|---|
PF00501 | AMP-binding enzyme |
PF13193 | AMP-binding enzyme C-terminal domain |
Reactome | Reactome Name | Node type | Reactome Root | Reactome Root Name |
---|---|---|---|---|
R-HSA-1989781 | PPARA activates gene expression | Leaf | R-HSA-1430728 | Metabolism |
R-HSA-2046105 | Linoleic acid (LA) metabolism | Leaf | R-HSA-1430728 | Metabolism |
R-HSA-2046106 | alpha-linolenic acid (ALA) metabolism | Leaf | R-HSA-1430728 | Metabolism |
R-HSA-75876 | Synthesis of very long-chain fatty acyl-CoAs | Leaf | R-HSA-1430728 | Metabolism |
Location | ECO term | Pubmed |
---|---|---|
Endoplasmic reticulum membrane | ECO:0000269 | PubMed:24269233 |
Microsome membrane | ECO:0000250 | |
Mitochondrion outer membrane | ECO:0000250 | |
Peroxisome membrane | ECO:0000250 |