Protein family
Protein sequence
Protein function
Catalytic activity
EC number
EC number description
3.6.1.23
Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides;
dUTP diphosphatase
PDB | Resolution (Å) | PDB name |
---|---|---|
1Q5H | 2.0 | Human dUTP Pyrophosphatase complex with dUDP |
1Q5U | 2.0 | HUMAN DUTP PYROPHOSPHATASE |
2HQU | 2.2 | Human dUTPase in complex with alpha,beta-iminodUTP and magnesium ion |
3ARA | 1.7 | Discovery of Novel Uracil Derivatives as Potent Human dUTPase Inhibitors |
3ARN | 1.8 | Human dUTPase in complex with novel uracil derivative |
3EHW | 1.8 | Human dUTPase in complex with alpha,beta-imido-dUTP and Mg2+: visualization of the full-length C-termini in all monomers and suggestion for an additional metal ion binding site |
4MZ5 | 2.1 | Structure of importin-alpha: dUTPase NLS complex |
4MZ6 | 1.88 | Structure of importin-alpha: dUTPase S11E NLS mutant complex |
5H4J | 1.8 | Crystal structure of Human dUTPase in complex with N-[(1R)-1-[3-(Cyclopentyloxy)-phenyl]-ethyl]-3-[(3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)methoxy]-1-propanesulfonamide |
7PWJ | 1.944 | dUTPase from human in complex with Stl |
GO ontology | GO term | GO description |
---|---|---|
Biological Process | GO:0006260 | DNA replication |
Biological Process | GO:0006231 | dTMP biosynthetic process |
Biological Process | GO:0006226 | dUMP biosynthetic process |
Biological Process | GO:0046081 | dUTP catabolic process |
Biological Process | GO:0001889 | liver development |
Biological Process | GO:0006139 | nucleobase-containing compound metabolic process |
Biological Process | GO:0043254 | regulation of protein-containing complex assembly |
Biological Process | GO:0014070 | response to organic cyclic compound |
Molecular Function | GO:0003723 | RNA binding |
Molecular Function | GO:0004170 | dUTP diphosphatase activity |
Molecular Function | GO:0042802 | identical protein binding |
Molecular Function | GO:0000287 | magnesium ion binding |
Molecular Function | GO:0042975 | peroxisome proliferator activated receptor binding |
Molecular Function | GO:0032556 | pyrimidine deoxyribonucleotide binding |
Molecular Function | GO:0030547 | signaling receptor inhibitor activity |
Cellular Component | GO:0005829 | cytosol |
Cellular Component | GO:0070062 | extracellular exosome |
Cellular Component | GO:0005739 | mitochondrion |
Cellular Component | GO:0005654 | nucleoplasm |
Cellular Component | GO:0005634 | nucleus |
Reactome | Reactome Name | Node type | Reactome Root | Reactome Root Name |
---|---|---|---|---|
R-HSA-499943 | Interconversion of nucleotide di- and triphosphates | Leaf | R-HSA-1430728 | Metabolism |
Location | ECO term | Pubmed |
---|---|---|
Mitochondrion | ECO:0000269 | PubMed:8631816 |
Mitochondrion | ECO:0000269 | PubMed:9070952 |
Nucleus | ECO:0000269 | PubMed:8631816 |
Nucleus | ECO:0000269 | PubMed:9070952 |
HPO ID | HPO name |
---|---|
HP:0000007 | Autosomal recessive inheritance |
HP:0001876 | Pancytopenia |
HP:0003593 | Infantile onset |
HP:0003621 | Juvenile onset |
HP:0003623 | Neonatal onset |
HP:0003764 | Nevus |
HP:0005518 | Increased mean corpuscular volume |
HP:0006727 | T-cell acute lymphoblastic leukemias |
HP:0025329 | Anti-glutamic acid decarboxylase antibody positivity |
HP:0034063 | Anti-islet antigen-2 antibody positivity |
HP:0100651 | Type I diabetes mellitus |
Disease name | MONDO ID | ICD10 | ICD10 chapter | OMIM | Orphanet |
---|---|---|---|---|---|
bone marrow failure and diabetes mellitus syndrome | MONDO:0859288 | - | - | OMIM:620044 |