MultifacetedProtDB - Bologna Biocomputing Group

EC number	EC number description
7.6.2.2	Translocases; Catalysing the translocation of other compounds; Linked to the hydrolysis of a nucleoside triphosphate; ABC-type xenobiotic transporter
7.6.2.3	Translocases; Catalysing the translocation of other compounds; Linked to the hydrolysis of a nucleoside triphosphate; ABC-type glutathione-S-conjugate transporter

Structure

PDB	Resolution (Å)	PDB name
2CBZ	1.5	Structure of the human Multidrug Resistance Protein 1 Nucleotide Binding Domain 1
4C3Z	2.1	Nucleotide-free crystal structure of nucleotide-binding domain 1 from human MRP1 supports a general-base catalysis mechanism for ATP hydrolysis.

GO term

GO ontology	GO term	GO description
Biological Process	GO:1905039	carboxylic acid transmembrane transport
Biological Process	GO:0060326	cell chemotaxis
Biological Process	GO:1904646	cellular response to amyloid-beta
Biological Process	GO:0034599	cellular response to oxidative stress
Biological Process	GO:0015889	cobalamin transport
Biological Process	GO:0070729	cyclic nucleotide transport
Biological Process	GO:0140115	export across plasma membrane
Biological Process	GO:0034775	glutathione transmembrane transport
Biological Process	GO:0042167	heme catabolic process
Biological Process	GO:0006691	leukotriene metabolic process
Biological Process	GO:0071716	leukotriene transport
Biological Process	GO:0045332	phospholipid translocation
Biological Process	GO:0050729	positive regulation of inflammatory response
Biological Process	GO:0009410	response to xenobiotic stimulus
Biological Process	GO:0099039	sphingolipid translocation
Biological Process	GO:0070633	transepithelial transport
Biological Process	GO:0055085	transmembrane transport
Biological Process	GO:0150104	transport across blood-brain barrier
Biological Process	GO:0006805	xenobiotic metabolic process
Biological Process	GO:0042908	xenobiotic transport
Biological Process	GO:1990962	xenobiotic transport across blood-brain barrier
Molecular Function	GO:0015431	ABC-type glutathione S-conjugate transporter activity
Molecular Function	GO:0140359	ABC-type transporter activity
Molecular Function	GO:0015420	ABC-type vitamin B12 transporter activity
Molecular Function	GO:0008559	ABC-type xenobiotic transporter activity
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0016887	ATP hydrolysis activity
Molecular Function	GO:0043225	ATPase-coupled inorganic anion transmembrane transporter activity
Molecular Function	GO:0034040	ATPase-coupled lipid transmembrane transporter activity
Molecular Function	GO:0042626	ATPase-coupled transmembrane transporter activity
Molecular Function	GO:0046943	carboxylic acid transmembrane transporter activity
Molecular Function	GO:0015562	efflux transmembrane transporter activity
Molecular Function	GO:0034634	glutathione transmembrane transporter activity
Molecular Function	GO:0042910	xenobiotic transmembrane transporter activity
Cellular Component	GO:0016324	apical plasma membrane
Cellular Component	GO:0009925	basal plasma membrane
Cellular Component	GO:0016323	basolateral plasma membrane
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0016328	lateral plasma membrane
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0005886	plasma membrane

InterPro	InterPro name
IPR003439	ABC transporter-like, ATP-binding domain
IPR003593	AAA+ ATPase domain
IPR005292	Multi drug resistance-associated protein
IPR011527	ABC transporter type 1, transmembrane domain
IPR017871	ABC transporter-like, conserved site
IPR027417	P-loop containing nucleoside triphosphate hydrolase
IPR036640	ABC transporter type 1, transmembrane domain superfamily

Pfam	Pfam name
PF00005	ABC transporter
PF00664	ABC transporter transmembrane region

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-189483	Heme degradation	Leaf	R-HSA-1430728	Metabolism
R-HSA-2142691	Synthesis of Leukotrienes (LT) and Eoxins (EX)	Leaf	R-HSA-1430728	Metabolism
R-HSA-382556	ABC-family proteins mediated transport	Internal node	R-HSA-382551	Transport of small molecules
R-HSA-9707564	Cytoprotection by HMOX1	Internal node	R-HSA-8953897	Cellular responses to stimuli
R-HSA-9753281	Paracetamol ADME	Leaf	R-HSA-9748784	Drug ADME
R-HSA-9758890	Transport of RCbl within the body	Leaf	R-HSA-1430728	Metabolism

Location	ECO term	Pubmed
Cell membrane	ECO:0000269	PubMed:16230346
Cell membrane	ECO:0000269	PubMed:31273342

HPO ID	HPO name
HP:0000006	Autosomal dominant inheritance
HP:0000360	Tinnitus
HP:0000407	Sensorineural hearing impairment
HP:0003581	Adult onset
HP:0011390	Morphological abnormality of the inner ear

Summary of P33527

Gene: ABCC1, MRP, MRP1
Protein: Multidrug resistance-associated protein 1

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of P33527

Gene: ABCC1, MRP, MRP1 Protein: Multidrug resistance-associated protein 1

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: ABCC1, MRP, MRP1
Protein: Multidrug resistance-associated protein 1