MultifacetedProtDB - Bologna Biocomputing Group

Structure

PDB	Resolution (Å)	PDB name
1G3J	2.1	CRYSTAL STRUCTURE OF THE XTCF3-CBD/BETA-CATENIN ARMADILLO REPEAT COMPLEX
1JDH	1.9	CRYSTAL STRUCTURE OF BETA-CATENIN AND HTCF-4
1JPW	2.5	Crystal Structure of a Human Tcf-4 / beta-Catenin Complex
1LUJ	2.5	Crystal Structure of the Beta-catenin/ICAT Complex
1P22	2.95	Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity on the SCFbeta-TrCP1 ubiquitin ligase
1QZ7	2.2	Beta-catenin binding domain of Axin in complex with beta-catenin
1T08	2.1	Crystal structure of beta-catenin/ICAT helical domain/unphosphorylated APC R3
1TH1	2.5	Beta-catenin in complex with a phosphorylated APC 20aa repeat fragment
2G57		Structure of the Phosphorylation Motif of the oncogenic Protein beta-Catenin Recognized By a Selective Monoclonal Antibody
2GL7	2.6	Crystal Structure of a beta-catenin/BCL9/Tcf4 complex
2Z6H	2.2	Crystal Structure of Beta-Catenin Armadillo Repeat Region and Its C-Terminal domain
3DIW	2.1	c-terminal beta-catenin bound TIP-1 structure
3FQN	1.65	Phosphorylation of self-peptides alters Human Leukocyte Antigen Class I-restricted antigen presentation and generates tumor specific epitopes
3FQR	1.7	Phosphorylation of self-peptides alters Human Leukocyte Antigen Class I-restricted antigen presentation and generates tumor specific epitopes
3SL9	2.2	X-ray structure of Beta catenin in complex with Bcl9
3SLA	2.5	X-ray structure of first four repeats of human beta-catenin
3TX7	2.76	Crystal structure of LRH-1/beta-catenin complex
4DJS	3.029	Structure of beta-catenin in complex with a stapled peptide inhibitor
6M90	2.05	Monophosphorylated pSer33 b-Catenin peptide, b-TrCP/Skp1, NRX-2776 ternary complex
6M91	2.4	Monophosphorylated pSer33 b-Catenin peptide, b-TrCP/Skp1, NRX-103094 ternary complex
6M92	2.35	Monophosphorylated pSer33 b-Catenin peptide, b-TrCP/Skp1, NRX-2663 ternary complex
6M93	2.5	Monophosphorylated pSer33 b-Catenin peptide, b-TrCP/Skp1, NRX-1933 ternary complex
6M94	2.7	Monophosphorylated pSer33 b-Catenin peptide bound to b-TrCP/Skp1 Complex
6O9B	2.2	Crystal structure of HLA-A3*01 in complex with a wild-type beta-catenin peptide
6O9C	2.45	Crystal structure of HLA-A3*01 in complex with a mutant beta-catenin peptide
6WLX	2.2	PAK4 kinase domain in complex with beta-catenin Ser675 substrate peptide
6WNX	2.5	FBXW11-SKP1 in complex with a pSer33/pSer37 Beta-Catenin peptide
7AFW	1.814	Beta-Catenin in complex with compound 6
7AR4	2.6	Crystal structure of beta-catenin in complex with cyclic peptide inhibitor
7UWI	2.32	Structure of beta-catenin in complex with FP01567, a Helicon Polypeptide
7UWO	2.75	Structure of beta-catenin in complex with FP05874, a Helicon Polypeptide

GO term

GO ontology	GO term	GO description
Biological Process	GO:0072054	renal outer medulla development
Biological Process	GO:0031069	hair follicle morphogenesis
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II
Biological Process	GO:0035115	embryonic forelimb morphogenesis
Biological Process	GO:2000288	positive regulation of myoblast proliferation
Biological Process	GO:0030539	male genitalia development
Biological Process	GO:0036023	embryonic skeletal limb joint morphogenesis
Biological Process	GO:0048599	oocyte development
Biological Process	GO:0001764	neuron migration
Biological Process	GO:0044336	canonical Wnt signaling pathway involved in negative regulation of apoptotic process
Biological Process	GO:0021854	hypothalamus development
Biological Process	GO:0009950	dorsal/ventral axis specification
Biological Process	GO:0000209	protein polyubiquitination
Biological Process	GO:0060441	epithelial tube branching involved in lung morphogenesis
Biological Process	GO:0032968	positive regulation of transcription elongation by RNA polymerase II
Biological Process	GO:0044334	canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition
Biological Process	GO:0019827	stem cell population maintenance
Biological Process	GO:0048664	neuron fate determination
Biological Process	GO:0060066	oviduct development
Biological Process	GO:0061198	fungiform papilla formation
Biological Process	GO:0070602	regulation of centromeric sister chromatid cohesion
Biological Process	GO:0035315	hair cell differentiation
Biological Process	GO:0050808	synapse organization
Biological Process	GO:0003266	regulation of secondary heart field cardioblast proliferation
Biological Process	GO:0031641	regulation of myelination
Biological Process	GO:0072497	mesenchymal stem cell differentiation
Biological Process	GO:0021819	layer formation in cerebral cortex
Biological Process	GO:0061324	canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation
Biological Process	GO:0060856	establishment of blood-brain barrier
Biological Process	GO:0035116	embryonic hindlimb morphogenesis
Biological Process	GO:0007268	chemical synaptic transmission
Biological Process	GO:0001658	branching involved in ureteric bud morphogenesis
Biological Process	GO:0034394	protein localization to cell surface
Biological Process	GO:0061549	sympathetic ganglion development
Biological Process	GO:0072089	stem cell proliferation
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity
Biological Process	GO:0031016	pancreas development
Biological Process	GO:0045743	positive regulation of fibroblast growth factor receptor signaling pathway
Biological Process	GO:2000008	regulation of protein localization to cell surface
Biological Process	GO:0060916	mesenchymal cell proliferation involved in lung development
Biological Process	GO:0030902	hindbrain development
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
Biological Process	GO:0045976	negative regulation of mitotic cell cycle, embryonic
Biological Process	GO:0006366	transcription by RNA polymerase II
Biological Process	GO:0044339	canonical Wnt signaling pathway involved in osteoblast differentiation
Biological Process	GO:0045597	positive regulation of cell differentiation
Biological Process	GO:0000904	cell morphogenesis involved in differentiation
Biological Process	GO:0009954	proximal/distal pattern formation
Biological Process	GO:0042475	odontogenesis of dentin-containing tooth
Biological Process	GO:0061550	cranial ganglion development
Biological Process	GO:0072182	regulation of nephron tubule epithelial cell differentiation
Biological Process	GO:0003340	negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
Biological Process	GO:0035112	genitalia morphogenesis
Biological Process	GO:0048617	embryonic foregut morphogenesis
Biological Process	GO:0002062	chondrocyte differentiation
Biological Process	GO:0007160	cell-matrix adhesion
Biological Process	GO:2001234	negative regulation of apoptotic signaling pathway
Biological Process	GO:0044338	canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation
Biological Process	GO:1990403	embryonic brain development
Biological Process	GO:1904954	canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation
Biological Process	GO:0022009	central nervous system vasculogenesis
Biological Process	GO:0071681	cellular response to indole-3-methanol
Biological Process	GO:0060440	trachea formation
Biological Process	GO:0051145	smooth muscle cell differentiation
Biological Process	GO:0036520	astrocyte-dopaminergic neuron signaling
Biological Process	GO:1904798	positive regulation of core promoter binding
Biological Process	GO:0060769	positive regulation of epithelial cell proliferation involved in prostate gland development
Biological Process	GO:0035995	detection of muscle stretch
Biological Process	GO:0001708	cell fate specification
Biological Process	GO:1904948	midbrain dopaminergic neuron differentiation
Biological Process	GO:0048145	regulation of fibroblast proliferation
Biological Process	GO:0010628	positive regulation of gene expression
Biological Process	GO:0032355	response to estradiol
Biological Process	GO:0051963	regulation of synapse assembly
Biological Process	GO:0001569	branching involved in blood vessel morphogenesis
Biological Process	GO:0061047	positive regulation of branching involved in lung morphogenesis
Biological Process	GO:0071363	cellular response to growth factor stimulus
Biological Process	GO:0043410	positive regulation of MAPK cascade
Biological Process	GO:0031396	regulation of protein ubiquitination
Biological Process	GO:0048469	cell maturation
Biological Process	GO:0002053	positive regulation of mesenchymal cell proliferation
Biological Process	GO:0060487	lung epithelial cell differentiation
Biological Process	GO:0072079	nephron tubule formation
Biological Process	GO:1903204	negative regulation of oxidative stress-induced neuron death
Biological Process	GO:0016525	negative regulation of angiogenesis
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II
Biological Process	GO:0090279	regulation of calcium ion import
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
Biological Process	GO:0008285	negative regulation of cell population proliferation
Biological Process	GO:0048538	thymus development
Biological Process	GO:0045765	regulation of angiogenesis
Biological Process	GO:0051973	positive regulation of telomerase activity
Biological Process	GO:0090425	acinar cell differentiation
Biological Process	GO:0007155	cell adhesion
Biological Process	GO:0051884	regulation of timing of anagen
Biological Process	GO:0060070	canonical Wnt signaling pathway
Biological Process	GO:0043065	positive regulation of apoptotic process
Biological Process	GO:0048660	regulation of smooth muscle cell proliferation
Biological Process	GO:0050767	regulation of neurogenesis
Biological Process	GO:0045669	positive regulation of osteoblast differentiation
Biological Process	GO:0033077	T cell differentiation in thymus
Biological Process	GO:0098609	cell-cell adhesion
Biological Process	GO:0009410	response to xenobiotic stimulus
Biological Process	GO:0042733	embryonic digit morphogenesis
Biological Process	GO:0007403	glial cell fate determination
Biological Process	GO:0051571	positive regulation of histone H3-K4 methylation
Biological Process	GO:0010909	positive regulation of heparan sulfate proteoglycan biosynthetic process
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway
Biological Process	GO:0001711	endodermal cell fate commitment
Biological Process	GO:0061154	endothelial tube morphogenesis
Biological Process	GO:0042129	regulation of T cell proliferation
Biological Process	GO:0002052	positive regulation of neuroblast proliferation
Biological Process	GO:1990791	dorsal root ganglion development
Biological Process	GO:0030997	regulation of centriole-centriole cohesion
Biological Process	GO:0032212	positive regulation of telomere maintenance via telomerase
Biological Process	GO:0003338	metanephros morphogenesis
Biological Process	GO:0097091	synaptic vesicle clustering
Biological Process	GO:0060742	epithelial cell differentiation involved in prostate gland development
Biological Process	GO:0072053	renal inner medulla development
Biological Process	GO:0007405	neuroblast proliferation
Biological Process	GO:0010629	negative regulation of gene expression
Biological Process	GO:0048643	positive regulation of skeletal muscle tissue development
Biological Process	GO:0051450	myoblast proliferation
Biological Process	GO:0043525	positive regulation of neuron apoptotic process
Biological Process	GO:0060767	epithelial cell proliferation involved in prostate gland development
Biological Process	GO:0045453	bone resorption
Biological Process	GO:0032331	negative regulation of chondrocyte differentiation
Biological Process	GO:0045603	positive regulation of endothelial cell differentiation
Biological Process	GO:0045892	negative regulation of DNA-templated transcription
Biological Process	GO:0034333	adherens junction assembly
Biological Process	GO:0045671	negative regulation of osteoclast differentiation
Biological Process	GO:0060492	lung induction
Biological Process	GO:0002089	lens morphogenesis in camera-type eye
Biological Process	GO:2000017	positive regulation of determination of dorsal identity
Biological Process	GO:0043524	negative regulation of neuron apoptotic process
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling
Biological Process	GO:0000165	MAPK cascade
Biological Process	GO:0060484	lung-associated mesenchyme development
Biological Process	GO:0007398	ectoderm development
Biological Process	GO:1904888	cranial skeletal system development
Biological Process	GO:1990138	neuron projection extension
Biological Process	GO:0001701	in utero embryonic development
Biological Process	GO:0001702	gastrulation with mouth forming second
Biological Process	GO:1990963	establishment of blood-retinal barrier
Biological Process	GO:0035050	embryonic heart tube development
Biological Process	GO:0010718	positive regulation of epithelial to mesenchymal transition
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway
Biological Process	GO:0048709	oligodendrocyte differentiation
Biological Process	GO:0043066	negative regulation of apoptotic process
Biological Process	GO:0001837	epithelial to mesenchymal transition
Biological Process	GO:0048489	synaptic vesicle transport
Biological Process	GO:0000578	embryonic axis specification
Biological Process	GO:0030316	osteoclast differentiation
Biological Process	GO:2000648	positive regulation of stem cell proliferation
Biological Process	GO:0009948	anterior/posterior axis specification
Biological Process	GO:0097190	apoptotic signaling pathway
Biological Process	GO:0033234	negative regulation of protein sumoylation
Biological Process	GO:0060789	hair follicle placode formation
Biological Process	GO:0072033	renal vesicle formation
Biological Process	GO:0001840	neural plate development
Biological Process	GO:0045893	positive regulation of DNA-templated transcription
Biological Process	GO:0048715	negative regulation of oligodendrocyte differentiation
Molecular Function	GO:0140297	DNA-binding transcription factor binding
Molecular Function	GO:0070411	I-SMAD binding
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding
Molecular Function	GO:0046332	SMAD binding
Molecular Function	GO:0045294	alpha-catenin binding
Molecular Function	GO:0045296	cadherin binding
Molecular Function	GO:0003682	chromatin binding
Molecular Function	GO:0097718	disordered domain specific binding
Molecular Function	GO:0019899	enzyme binding
Molecular Function	GO:1990226	histone methyltransferase binding
Molecular Function	GO:0019900	kinase binding
Molecular Function	GO:0030331	nuclear estrogen receptor binding
Molecular Function	GO:0016922	nuclear receptor binding
Molecular Function	GO:0019901	protein kinase binding
Molecular Function	GO:0019903	protein phosphatase binding
Molecular Function	GO:0003713	transcription coactivator activity
Molecular Function	GO:0001221	transcription coregulator binding
Molecular Function	GO:0001222	transcription corepressor binding
Molecular Function	GO:0044325	transmembrane transporter binding
Molecular Function	GO:0031625	ubiquitin protein ligase binding
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse
Cellular Component	GO:0034750	Scrib-APC-beta-catenin complex
Cellular Component	GO:1990909	Wnt signalosome
Cellular Component	GO:0030018	Z disc
Cellular Component	GO:0005912	adherens junction
Cellular Component	GO:0045177	apical part of cell
Cellular Component	GO:0016327	apicolateral plasma membrane
Cellular Component	GO:0016323	basolateral plasma membrane
Cellular Component	GO:0030877	beta-catenin destruction complex
Cellular Component	GO:1990711	beta-catenin-ICAT complex
Cellular Component	GO:1990907	beta-catenin-TCF complex
Cellular Component	GO:0070369	beta-catenin-TCF7L2 complex
Cellular Component	GO:0005923	bicellular tight junction
Cellular Component	GO:0016342	catenin complex
Cellular Component	GO:0005938	cell cortex
Cellular Component	GO:0030054	cell junction
Cellular Component	GO:0071944	cell periphery
Cellular Component	GO:0005911	cell-cell junction
Cellular Component	GO:0005813	centrosome
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0000791	euchromatin
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0005916	fascia adherens
Cellular Component	GO:0016600	flotillin complex
Cellular Component	GO:0005925	focal adhesion
Cellular Component	GO:0098978	glutamatergic synapse
Cellular Component	GO:0030027	lamellipodium
Cellular Component	GO:0016328	lateral plasma membrane
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0031528	microvillus membrane
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0048471	perinuclear region of cytoplasm
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0099092	postsynaptic density, intracellular component
Cellular Component	GO:0045211	postsynaptic membrane
Cellular Component	GO:0098831	presynaptic active zone cytoplasmic component
Cellular Component	GO:0042734	presynaptic membrane
Cellular Component	GO:0032993	protein-DNA complex
Cellular Component	GO:0032991	protein-containing complex
Cellular Component	GO:0000922	spindle pole
Cellular Component	GO:0045202	synapse
Cellular Component	GO:0005667	transcription regulator complex

InterPro / Pfam

InterPro	InterPro name
IPR000225	Armadillo
IPR011989	Armadillo-like helical
IPR013284	Beta-catenin
IPR016024	Armadillo-type fold

Pfam	Pfam name
PF00514	Armadillo/beta-catenin-like repeat

Reactome

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-195253	Degradation of beta-catenin by the destruction complex	Internal node	R-HSA-162582	Signal Transduction
R-HSA-196299	Beta-catenin phosphorylation cascade	Leaf	R-HSA-162582	Signal Transduction
R-HSA-201681	TCF dependent signaling in response to WNT	Internal node	R-HSA-162582	Signal Transduction
R-HSA-201722	Formation of the beta-catenin:TCF transactivating complex	Internal node	R-HSA-162582	Signal Transduction
R-HSA-3134973	LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	Leaf	R-HSA-168256	Immune System
R-HSA-351906	Apoptotic cleavage of cell adhesion proteins	Leaf	R-HSA-5357801	Programmed Cell Death
R-HSA-3769402	Deactivation of the beta-catenin transactivating complex	Leaf	R-HSA-162582	Signal Transduction
R-HSA-381771	Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-4086398	Ca2+ pathway	Leaf	R-HSA-162582	Signal Transduction
R-HSA-418990	Adherens junctions interactions	Internal node	R-HSA-1500931	Cell-Cell communication
R-HSA-4411364	Binding of TCF/LEF:CTNNB1 to target gene promoters	Leaf	R-HSA-162582	Signal Transduction
R-HSA-4641262	Disassembly of the destruction complex and recruitment of AXIN to the membrane	Leaf	R-HSA-162582	Signal Transduction
R-HSA-5218920	VEGFR2 mediated vascular permeability	Leaf	R-HSA-162582	Signal Transduction
R-HSA-525793	Myogenesis	Leaf	R-HSA-1266738	Developmental Biology
R-HSA-5339716	Signaling by GSK3beta mutants	Leaf	R-HSA-1643685	Disease
R-HSA-5358747	CTNNB1 S33 mutants aren't phosphorylated	Leaf	R-HSA-1643685	Disease
R-HSA-5358749	CTNNB1 S37 mutants aren't phosphorylated	Leaf	R-HSA-1643685	Disease
R-HSA-5358751	CTNNB1 S45 mutants aren't phosphorylated	Leaf	R-HSA-1643685	Disease
R-HSA-5358752	CTNNB1 T41 mutants aren't phosphorylated	Leaf	R-HSA-1643685	Disease
R-HSA-5626467	RHO GTPases activate IQGAPs	Leaf	R-HSA-162582	Signal Transduction
R-HSA-8853884	Transcriptional Regulation by VENTX	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-8876493	InlA-mediated entry of Listeria monocytogenes into host cells	Leaf	R-HSA-1643685	Disease
R-HSA-8951430	RUNX3 regulates WNT signaling	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-9754189	Germ layer formation at gastrulation	Leaf	R-HSA-1266738	Developmental Biology
R-HSA-9793380	Formation of paraxial mesoderm	Internal node	R-HSA-1266738	Developmental Biology
R-HSA-9796292	Formation of axial mesoderm	Leaf	R-HSA-1266738	Developmental Biology

Subcellular location

Location	ECO term	Pubmed
Cell junction	ECO:0000250
Cell junction, adherens junction	ECO:0000269	PubMed:10725230
Cell membrane	ECO:0000269	PubMed:11790773
Cell membrane	ECO:0000269	PubMed:24342833
Cytoplasm	ECO:0000269	PubMed:25183871
Cytoplasm	ECO:0000269	PubMed:29739711
Cytoplasm	ECO:0000269	PubMed:31801859
Cytoplasm, cytoskeleton	ECO:0000250
Cytoplasm, cytoskeleton, cilium basal body	ECO:0000250
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Cytoplasm, cytoskeleton, spindle pole
Nucleus	ECO:0000269	PubMed:24342833
Nucleus	ECO:0000269	PubMed:25183871
Nucleus	ECO:0000269	PubMed:28829046
Nucleus	ECO:0000269	PubMed:29367600
Nucleus	ECO:0000269	PubMed:29739711
Nucleus	ECO:0000269	PubMed:31801859
Synapse	ECO:0000250

Interactor | Variant | Drug

Phenotype

HPO ID	HPO name
HP:0040049	Macular edema
HP:0002315	Headache
HP:0000568	Microphthalmia
HP:0004324	Increased body weight
HP:0025336	Delayed ability to sit
HP:0002637	Cerebral ischemia
HP:0001395	Hepatic fibrosis
HP:0000080	Abnormality of reproductive system physiology
HP:0410019	Epigastric pain
HP:0030242	Portal vein thrombosis
HP:0006254	Elevated circulating alpha-fetoprotein concentration
HP:0002024	Malabsorption
HP:0040075	Hypopituitarism
HP:0000006	Autosomal dominant inheritance
HP:0000430	Underdeveloped nasal alae
HP:0010766	Ectopic calcification
HP:0007924	Slow decrease in visual acuity
HP:0000711	Restlessness
HP:0100014	Epiretinal membrane
HP:0000737	Irritability
HP:0002516	Increased intracranial pressure
HP:0030666	Retinal neovascularization
HP:0003621	Juvenile onset
HP:0002719	Recurrent infections
HP:0012505	Enlarged pituitary gland
HP:0008052	Retinal fold
HP:0001376	Limitation of joint mobility
HP:0030496	Macular exudate
HP:0005214	Intestinal obstruction
HP:0003508	Proportionate short stature
HP:0031526	Subretinal fluid
HP:0008897	Postnatal growth retardation
HP:0007703	Abnormality of retinal pigmentation
HP:0001141	Severely reduced visual acuity
HP:0000739	Anxiety
HP:0007773	Vitreoretinopathy
HP:0002891	Uterine leiomyosarcoma
HP:0012288	Neoplasm of head and neck
HP:0006774	Ovarian papillary adenocarcinoma
HP:0002591	Polyphagia
HP:0025436	Elevated serum 11-deoxycortisol
HP:0000863	Central diabetes insipidus
HP:0004349	Reduced bone mineral density
HP:0030588	Abnormal visual field test
HP:0000822	Hypertension
HP:0100749	Chest pain
HP:0003396	Syringomyelia
HP:0002191	Progressive spasticity
HP:0000533	Chorioretinal atrophy
HP:0002079	Hypoplasia of the corpus callosum
HP:0001263	Global developmental delay
HP:0030348	Increased circulating androgen concentration
HP:0010576	Intracranial cystic lesion
HP:0002015	Dysphagia
HP:0001262	Excessive daytime somnolence
HP:0002376	Developmental regression
HP:0002239	Gastrointestinal hemorrhage
HP:0002900	Hypokalemia
HP:0001824	Weight loss
HP:0000486	Strabismus
HP:0002360	Sleep disturbance
HP:0002240	Hepatomegaly
HP:0003002	Breast carcinoma
HP:0010939	Abnormal nasal bone morphology
HP:0001500	Broad finger
HP:0004298	Abnormality of the abdominal wall
HP:0000545	Myopia
HP:0002144	Tethered cord
HP:0008936	Axial hypotonia
HP:0000252	Microcephaly
HP:0000540	Hypermetropia
HP:0100832	Vitreous floaters
HP:0010614	Fibroma
HP:0003011	Abnormality of the musculature
HP:0002188	Delayed CNS myelination
HP:0001493	Falciform retinal fold
HP:0007685	Peripheral retinal avascularization
HP:0000546	Retinal degeneration
HP:0000819	Diabetes mellitus
HP:0002321	Vertigo
HP:0011750	Neoplasm of the anterior pituitary
HP:0006740	Transitional cell carcinoma of the bladder
HP:0000639	Nystagmus
HP:0033559	Anti-myeloperoxidase antibody positivity
HP:0000007	Autosomal recessive inheritance
HP:0002013	Vomiting
HP:0030490	Exudative vitreoretinopathy
HP:0001413	Micronodular cirrhosis
HP:0012378	Fatigue
HP:0002514	Cerebral calcification
HP:0002650	Scoliosis
HP:0003110	Abnormality of urine homeostasis
HP:0000648	Optic atrophy
HP:0200008	Intestinal polyposis
HP:0001482	Subcutaneous nodule
HP:0000742	Self-mutilation
HP:0025269	Panic attack
HP:0012795	Abnormal optic disc morphology
HP:0000044	Hypogonadotropic hypogonadism
HP:0001249	Intellectual disability
HP:0001264	Spastic diplegia
HP:0006744	Adrenocortical carcinoma
HP:0003593	Infantile onset
HP:0002027	Abdominal pain
HP:0006753	Neoplasm of the stomach
HP:0011734	Central adrenal insufficiency
HP:0000518	Cataract
HP:0000365	Hearing impairment
HP:0000998	Hypertrichosis
HP:0030503	Macular telangiectasia
HP:0000455	Broad nasal tip
HP:0007917	Tractional retinal detachment
HP:0001065	Striae distensae
HP:0000718	Aggressive behavior
HP:0000541	Retinal detachment
HP:0009765	Low hanging columella
HP:0002605	Hepatic necrosis
HP:0030521	Bitemporal hemianopia
HP:0007987	Progressive visual field defects
HP:0002885	Medulloblastoma
HP:0000238	Hydrocephalus
HP:0001939	Abnormality of metabolism/homeostasis
HP:0000478	Abnormality of the eye
HP:0007902	Vitreous hemorrhage
HP:0000219	Thin upper lip vermilion
HP:0033128	Delayed ability to crawl
HP:0100245	Desmoid tumors
HP:0010535	Sleep apnea
HP:0000319	Smooth philtrum
HP:0001402	Hepatocellular carcinoma
HP:0010935	Abnormality of the upper urinary tract
HP:0001428	Somatic mutation
HP:0003466	Paradoxical increased cortisol secretion on dexamethasone suppression test
HP:0008245	Pituitary hypothyroidism
HP:0006716	Hereditary nonpolyposis colorectal carcinoma
HP:0100621	Dysgerminoma
HP:0001518	Small for gestational age
HP:0003118	Increased circulating cortisol level
HP:0000135	Hypogonadism
HP:0011451	Primary microcephaly
HP:0001658	Myocardial infarction
HP:0001270	Motor delay
HP:0030434	Pilomatrixoma
HP:0006572	Subacute progressive viral hepatitis
HP:0001252	Hypotonia
HP:0011968	Feeding difficulties
HP:0005584	Renal cell carcinoma
HP:0001085	Papilledema
HP:0100716	Self-injurious behavior
HP:0002829	Arthralgia
HP:0012230	Rhegmatogenous retinal detachment
HP:0003623	Neonatal onset
HP:0001117	Sudden loss of visual acuity
HP:0008069	Neoplasm of the skin
HP:0000708	Atypical behavior
HP:0000859	Hyperaldosteronism
HP:0001257	Spasticity
HP:0000975	Hyperhidrosis
HP:0002797	Osteolysis
HP:0001259	Coma
HP:0000218	High palate
HP:0001256	Intellectual disability, mild
HP:0002017	Nausea and vomiting
HP:0001510	Growth delay
HP:0500022	Abnormal circulating dehydroepiandrosterone concentration
HP:0011748	Adrenocorticotropic hormone deficiency
HP:0007663	Reduced visual acuity
HP:0025380	Increased circulating androstenedione concentration
HP:0025160	Abnormal temper tantrums
HP:0002465	Poor speech
HP:0000126	Hydronephrosis
HP:0012030	Increased urinary cortisol level
HP:0002659	Increased susceptibility to fractures
HP:0001962	Palpitations
HP:0100806	Sepsis
HP:0003326	Myalgia
HP:0012286	Abnormal hypothalamus morphology
HP:0005978	Type II diabetes mellitus
HP:0030078	Lung adenocarcinoma
HP:0000989	Pruritus
HP:0000870	Increased circulating prolactin concentration
HP:0000823	Delayed puberty
HP:0025134	Increased serum estradiol
HP:0031936	Delayed ability to walk
HP:0001004	Lymphedema
HP:0430000	Abnormal frontal bone morphology
HP:0002119	Ventriculomegaly
HP:0001250	Seizure
HP:0000729	Autistic behavior
HP:0011342	Mild global developmental delay
HP:0011530	Retinal hole
HP:0000343	Long philtrum
HP:0001513	Obesity
HP:0001324	Muscle weakness
HP:0003829	Typified by incomplete penetrance
HP:0001999	Abnormal facial shape
HP:0000618	Blindness

Tissue and cell type

Tissue	Cell type	Expression level	Reliability
adrenal gland	glandular cells	High	Supported
appendix	glandular cells	High	Supported
bone marrow	hematopoietic cells	Low	Supported
breast	glandular cells	High	Supported
breast	myoepithelial cells	High	Supported
bronchus	respiratory epithelial cells	High	Supported
caudate	glial cells	Low	Supported
caudate	neuronal cells	Low	Supported
cerebellum	Purkinje cells - cytoplasm/membrane	Medium	Supported
cerebellum	Purkinje cells - nucleus	High	Supported
cerebellum	granular cells - cytoplasm/membrane	High	Supported
cerebellum	molecular layer cells - nucleus	High	Supported
cerebellum	white matter cells - cytoplasm/membrane	High	Supported
cerebral cortex	endothelial cells	Low	Supported
cerebral cortex	glial cells	Low	Supported
cerebral cortex	neuronal cells	Low	Supported
cerebral cortex	neuropil	Medium	Supported
cervix	glandular cells	High	Supported
cervix	squamous epithelial cells	High	Supported
colon	endothelial cells	Medium	Supported
colon	glandular cells	High	Supported
colon	peripheral nerve/ganglion	Medium	Supported
duodenum	glandular cells	High	Supported
endometrium 1	cells in endometrial stroma	Low	Supported
endometrium 1	glandular cells	High	Supported
endometrium 2	cells in endometrial stroma	Low	Supported
endometrium 2	glandular cells	High	Supported
epididymis	glandular cells	High	Supported
esophagus	squamous epithelial cells	High	Supported
fallopian tube	glandular cells	High	Supported
gallbladder	glandular cells	High	Supported
heart muscle	cardiomyocytes	High	Supported
hippocampus	glial cells	Low	Supported
hippocampus	neuronal cells	Low	Supported
kidney	cells in glomeruli	Low	Supported
kidney	cells in tubules	High	Supported
liver	cholangiocytes	High	Supported
liver	hepatocytes	High	Supported
lung	alveolar cells type I	Low	Supported
lung	alveolar cells type II	Medium	Supported
lung	endothelial cells	Medium	Supported
lung	macrophages	Medium	Supported
nasopharynx	respiratory epithelial cells	High	Supported
oral mucosa	squamous epithelial cells	High	Supported
ovary	ovarian stroma cells	Low	Supported
pancreas	exocrine glandular cells	High	Supported
pancreas	pancreatic endocrine cells	Medium	Supported
parathyroid gland	glandular cells	High	Supported
placenta	decidual cells	Medium	Supported
placenta	trophoblastic cells	High	Supported
prostate	glandular cells	High	Supported
rectum	glandular cells	High	Supported
salivary gland	glandular cells	High	Supported
seminal vesicle	glandular cells	High	Supported
skin 1	cells in basal layer	High	Supported
skin 1	cells in granular layer	High	Supported
skin 1	cells in spinous layer	High	Supported
skin 1	eccrine glands	High	Supported
skin 1	endothelial cells	High	Supported
skin 1	hair follicles	High	Supported
skin 1	langerhans cells	High	Supported
skin 1	melanocytes	High	Supported
skin 1	sebaceous glands	High	Supported
skin 2	cells in basal layer	High	Supported
skin 2	cells in granular layer	High	Supported
skin 2	cells in spinous layer	High	Supported
skin 2	eccrine glands	High	Supported
skin 2	endothelial cells	High	Supported
skin 2	langerhans cells	High	Supported
skin 2	melanocytes	High	Supported
skin 2	sebaceous glands	High	Supported
small intestine	glandular cells	High	Supported
soft tissue 1	peripheral nerve	Medium	Supported
soft tissue 2	peripheral nerve	Medium	Supported
stomach 1	glandular cells	High	Supported
stomach 2	glandular cells	High	Supported
testis	sertoli cells	Medium	Supported
testis	spermatogonia cells	High	Supported
thyroid gland	glandular cells	High	Supported
tonsil	squamous epithelial cells	High	Supported
urinary bladder	urothelial cells	High	Supported
vagina	squamous epithelial cells	High	Supported

Disease name	MONDO ID	ICD10	ICD10 chapter	OMIM	Orphanet
colorectal cancer	MONDO:0005575	C18	chapter2, Neoplasms	OMIM:114500	Orphanet:466667
malignant mesothelioma	MONDO:0006292	C45	chapter2, Neoplasms	OMIM:156240	Orphanet:50251
hepatocellular carcinoma	MONDO:0007256	C22	chapter2, Neoplasms	OMIM:114550	Orphanet:88673
pilomatrixoma	MONDO:0007564	C44	chapter2, Neoplasms	OMIM:132600	Orphanet:91414
desmoid tumor	MONDO:0007608	D48	chapter2, Neoplasms	OMIM:135290	Orphanet:873
medulloblastoma	MONDO:0007959	C71	chapter2, Neoplasms	OMIM:155255	Orphanet:616
ovarian cancer	MONDO:0008170	C56	chapter2, Neoplasms	OMIM:167000	Orphanet:213500
severe intellectual disability-progressive spastic diplegia syndrome	MONDO:0014035	G11	chapter6, Diseases of the nervous system	OMIM:615075	Orphanet:404473
craniopharyngioma	MONDO:0018907	D44	chapter2, Neoplasms		Orphanet:54595
exudative vitreoretinopathy 7	MONDO:0033123	H35	chapter7, Diseases of the eye and adnexa	OMIM:617572

Summary of P35222

Gene: CTNNB1, CTNNB, OK/SW-cl.35, PRO2286
Protein: Catenin beta-1

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of P35222

Gene: CTNNB1, CTNNB, OK/SW-cl.35, PRO2286 Protein: Catenin beta-1

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: CTNNB1, CTNNB, OK/SW-cl.35, PRO2286
Protein: Catenin beta-1