Protein family
The protein has not catalytic activity
Protein sequence
Protein function
Publications
Catalytic activity
| PDB | Resolution (Å) | PDB name |
|---|
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0042113 | B cell activation |
| Biological Process | GO:0023035 | CD40 signaling pathway |
| Biological Process | GO:0071897 | DNA biosynthetic process |
| Biological Process | GO:0039529 | RIG-I signaling pathway |
| Biological Process | GO:0072538 | T-helper 17 type immune response |
| Biological Process | GO:0007202 | activation of phospholipase C activity |
| Biological Process | GO:1990051 | activation of protein kinase C activity |
| Biological Process | GO:0140374 | antiviral innate immune response |
| Biological Process | GO:0071354 | cellular response to interleukin-6 |
| Biological Process | GO:0040029 | epigenetic regulation of gene expression |
| Biological Process | GO:0007005 | mitochondrion organization |
| Biological Process | GO:0044830 | modulation by host of viral RNA genome replication |
| Biological Process | GO:0045892 | negative regulation of DNA-templated transcription |
| Biological Process | GO:0070373 | negative regulation of ERK1 and ERK2 cascade |
| Biological Process | GO:0060766 | negative regulation of androgen receptor signaling pathway |
| Biological Process | GO:0030308 | negative regulation of cell growth |
| Biological Process | GO:0008285 | negative regulation of cell population proliferation |
| Biological Process | GO:2000323 | negative regulation of glucocorticoid receptor signaling pathway |
| Biological Process | GO:0042177 | negative regulation of protein catabolic process |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0010944 | negative regulation of transcription by competitive promoter binding |
| Biological Process | GO:0001649 | osteoblast differentiation |
| Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
| Biological Process | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| Biological Process | GO:0045745 | positive regulation of G protein-coupled receptor signaling pathway |
| Biological Process | GO:1901224 | positive regulation of NIK/NF-kappaB signaling |
| Biological Process | GO:0010942 | positive regulation of cell death |
| Biological Process | GO:0045917 | positive regulation of complement activation |
| Biological Process | GO:0010628 | positive regulation of gene expression |
| Biological Process | GO:0002639 | positive regulation of immunoglobulin production |
| Biological Process | GO:0032740 | positive regulation of interleukin-17 production |
| Biological Process | GO:0051897 | positive regulation of protein kinase B signaling |
| Biological Process | GO:0048661 | positive regulation of smooth muscle cell proliferation |
| Biological Process | GO:0050847 | progesterone receptor signaling pathway |
| Biological Process | GO:0050821 | protein stabilization |
| Biological Process | GO:0006355 | regulation of DNA-templated transcription |
| Biological Process | GO:0042981 | regulation of apoptotic process |
| Biological Process | GO:0007165 | signal transduction |
| Biological Process | GO:0046718 | viral entry into host cell |
| Molecular Function | GO:0001850 | complement component C3a binding |
| Molecular Function | GO:0001851 | complement component C3b binding |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0042826 | histone deacetylase binding |
| Molecular Function | GO:0046982 | protein heterodimerization activity |
| Molecular Function | GO:0031871 | proteinase activated receptor binding |
| Molecular Function | GO:0003714 | transcription corepressor activity |
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005769 | early endosome |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0035632 | mitochondrial prohibitin complex |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005886 | plasma membrane |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-5673000 | RAF activation | Leaf | R-HSA-162582 | Signal Transduction |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | Leaf | R-HSA-1643685 | Disease |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | Leaf | R-HSA-1643685 | Disease |
| R-HSA-8949664 | Processing of SMDT1 | Leaf | R-HSA-382551 | Transport of small molecules |
| R-HSA-9649948 | Signaling downstream of RAS mutants | Leaf | R-HSA-1643685 | Disease |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Cell membrane | ECO:0000269 | PubMed:22997079 |
| Cell membrane | ECO:0000269 | PubMed:24003225 |
| Cytoplasm | ECO:0000269 | PubMed:14500729 |
| Cytoplasm | ECO:0000269 | PubMed:31899195 |
| Mitochondrion inner membrane | ECO:0000269 | PubMed:14500729 |
| Mitochondrion inner membrane | ECO:0000269 | PubMed:20959514 |
| Nucleus | ECO:0000269 | PubMed:14500729 |
| Nucleus | ECO:0000269 | PubMed:20959514 |
| Nucleus | ECO:0000269 | PubMed:31899195 |
| HPO ID
|
HPO name |
|---|---|
| HP:0000006 | Autosomal dominant inheritance |
| HP:0001428 | Somatic mutation |
| HP:0003002 | Breast carcinoma |
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adipose tissue | adipocytes | Medium | Supported |
| adrenal gland | glandular cells | High | Supported |
| appendix | glandular cells | High | Supported |
| appendix | lymphoid tissue | High | Supported |
| bone marrow | hematopoietic cells | High | Supported |
| breast | adipocytes | Medium | Supported |
| breast | glandular cells | High | Supported |
| breast | myoepithelial cells | Medium | Supported |
| bronchus | respiratory epithelial cells | High | Supported |
| caudate | glial cells | High | Supported |
| caudate | neuronal cells | High | Supported |
| cerebellum | Purkinje cells | High | Supported |
| cerebellum | cells in granular layer | Medium | Supported |
| cerebellum | cells in molecular layer | Medium | Supported |
| cerebral cortex | endothelial cells | Medium | Supported |
| cerebral cortex | glial cells | High | Supported |
| cerebral cortex | neuronal cells | Medium | Supported |
| cerebral cortex | neuropil | Low | Supported |
| cervix | glandular cells | High | Supported |
| cervix | squamous epithelial cells | High | Supported |
| colon | glandular cells | High | Supported |
| duodenum | glandular cells | High | Supported |
| endometrium 1 | cells in endometrial stroma | High | Supported |
| endometrium 1 | glandular cells | High | Supported |
| endometrium 2 | cells in endometrial stroma | High | Supported |
| endometrium 2 | glandular cells | High | Supported |
| epididymis | glandular cells | High | Supported |
| esophagus | squamous epithelial cells | High | Supported |
| fallopian tube | glandular cells | High | Supported |
| gallbladder | glandular cells | High | Supported |
| heart muscle | cardiomyocytes | Medium | Supported |
| hippocampus | glial cells | Medium | Supported |
| hippocampus | neuronal cells | High | Supported |
| kidney | bowman's capsule | High | Supported |
| kidney | cells in glomeruli | Medium | Supported |
| kidney | collecting ducts | High | Supported |
| kidney | distal tubules | High | Supported |
| kidney | proximal tubules (cell body) | High | Supported |
| liver | cholangiocytes | High | Supported |
| liver | hepatocytes | High | Supported |
| lung | alveolar cells type I | High | Supported |
| lung | endothelial cells | High | Supported |
| lung | macrophages | High | Supported |
| lymph node | non-germinal center cells | High | Supported |
| oral mucosa | squamous epithelial cells | High | Supported |
| ovary | follicle cells | High | Supported |
| ovary | ovarian stroma cells | High | Supported |
| pancreas | exocrine glandular cells | High | Supported |
| parathyroid gland | glandular cells | High | Supported |
| placenta | decidual cells | Medium | Supported |
| placenta | trophoblastic cells | High | Supported |
| prostate | glandular cells | High | Supported |
| rectum | glandular cells | High | Supported |
| salivary gland | glandular cells | High | Supported |
| seminal vesicle | glandular cells | High | Supported |
| skeletal muscle | myocytes | Medium | Supported |
| skin 1 | cells in basal layer | Medium | Supported |
| skin 1 | cells in granular layer | Medium | Supported |
| skin 1 | cells in spinous layer | Medium | Supported |
| skin 1 | fibrohistiocytic cells | Low | Supported |
| skin 1 | langerhans cells | Medium | Supported |
| skin 1 | lymphocytes | Medium | Supported |
| skin 1 | melanocytes | Medium | Supported |
| skin 2 | cells in basal layer | High | Supported |
| skin 2 | cells in granular layer | High | Supported |
| skin 2 | cells in spinous layer | High | Supported |
| skin 2 | eccrine glands | High | Supported |
| skin 2 | endothelial cells | High | Supported |
| skin 2 | fibrohistiocytic cells | High | Supported |
| skin 2 | langerhans cells | High | Supported |
| skin 2 | lymphocytes | High | Supported |
| skin 2 | melanocytes | High | Supported |
| small intestine | glandular cells | High | Supported |
| smooth muscle | smooth muscle cells | High | Supported |
| soft tissue 1 | fibroblasts | High | Supported |
| soft tissue 2 | fibroblasts | Medium | Supported |
| spleen | cells in red pulp | High | Supported |
| spleen | cells in white pulp | High | Supported |
| stomach 1 | glandular cells | High | Supported |
| stomach 2 | glandular cells | Medium | Supported |
| testis | Leydig cells | High | Supported |
| testis | sertoli cells | Medium | Supported |
| testis | spermatogonia cells | High | Supported |
| thyroid gland | glandular cells | High | Supported |
| tonsil | germinal center cells | High | Supported |
| tonsil | non-germinal center cells | High | Supported |
| tonsil | squamous epithelial cells | High | Supported |
| urinary bladder | urothelial cells | High | Supported |
| vagina | squamous epithelial cells | High | Supported |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|