MultifacetedProtDB - Bologna Biocomputing Group

Structure

PDB	Resolution (Å)	PDB name
2OIT	1.65	Crystal Structure of the N-terminal Domain of the Human Proto-oncogene Nup214/CAN
3FHC	2.8	Crystal structure of human Dbp5 in complex with Nup214
3FMO	2.51	Crystal structure of the nucleoporin Nup214 in complex with the DEAD-box helicase Ddx19
3FMP	3.19	Crystal structure of the nucleoporin Nup214 in complex with the DEAD-box helicase Ddx19
5DIS	2.85	Crystal structure of a CRM1-RanGTP-SPN1 export complex bound to a 113 amino acid FG-repeat containing fragment of Nup214
7R5J	50.0	Human nuclear pore complex (dilated)
7R5K	12.0	Human nuclear pore complex (constricted)

GO term

GO ontology	GO term	GO description
Biological Process	GO:0006405	RNA export from nucleus
Biological Process	GO:0006406	mRNA export from nucleus
Biological Process	GO:0000278	mitotic cell cycle
Biological Process	GO:0006913	nucleocytoplasmic transport
Biological Process	GO:0006611	protein export from nucleus
Biological Process	GO:0006606	protein import into nucleus
Biological Process	GO:0051726	regulation of cell cycle
Biological Process	GO:0046822	regulation of nucleocytoplasmic transport
Molecular Function	GO:0005049	nuclear export signal receptor activity
Molecular Function	GO:0008139	nuclear localization sequence binding
Molecular Function	GO:0017056	structural constituent of nuclear pore
Cellular Component	GO:1990876	cytoplasmic side of nuclear pore
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005635	nuclear envelope
Cellular Component	GO:0005643	nuclear pore
Cellular Component	GO:0005654	nucleoplasm

InterPro / Pfam

InterPro	InterPro name
IPR001680	WD40 repeat
IPR015943	WD40/YVTN repeat-like-containing domain superfamily
IPR026054	Nuclear pore complex protein
IPR041553	Nuclear pore complex protein Nup214, phenylalanine-glycine (FG) domain

Pfam	Pfam name
PF18617	Nucleoporin Nup214 phenylalanine-glycine (FG) domain

Reactome

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-1169408	ISG15 antiviral mechanism	Leaf	R-HSA-168256	Immune System
R-HSA-159227	Transport of the SLBP independent Mature mRNA	Leaf	R-HSA-8953854	Metabolism of RNA
R-HSA-159230	Transport of the SLBP Dependant Mature mRNA	Leaf	R-HSA-8953854	Metabolism of RNA
R-HSA-159231	Transport of Mature mRNA Derived from an Intronless Transcript	Leaf	R-HSA-8953854	Metabolism of RNA
R-HSA-159236	Transport of Mature mRNA derived from an Intron-Containing Transcript	Leaf	R-HSA-8953854	Metabolism of RNA
R-HSA-165054	Rev-mediated nuclear export of HIV RNA	Leaf	R-HSA-1643685	Disease
R-HSA-168271	Transport of Ribonucleoproteins into the Host Nucleus	Leaf	R-HSA-1643685	Disease
R-HSA-168276	NS1 Mediated Effects on Host Pathways	Internal node	R-HSA-1643685	Disease
R-HSA-168325	Viral Messenger RNA Synthesis	Leaf	R-HSA-1643685	Disease
R-HSA-168333	NEP/NS2 Interacts with the Cellular Export Machinery	Leaf	R-HSA-1643685	Disease
R-HSA-170822	Regulation of Glucokinase by Glucokinase Regulatory Protein	Leaf	R-HSA-1430728	Metabolism
R-HSA-180746	Nuclear import of Rev protein	Leaf	R-HSA-1643685	Disease
R-HSA-180910	Vpr-mediated nuclear import of PICs	Leaf	R-HSA-1643685	Disease
R-HSA-191859	snRNP Assembly	Leaf	R-HSA-8953854	Metabolism of RNA
R-HSA-3108214	SUMOylation of DNA damage response and repair proteins	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-3232142	SUMOylation of ubiquitinylation proteins	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-3301854	Nuclear Pore Complex (NPC) Disassembly	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-3371453	Regulation of HSF1-mediated heat shock response	Leaf	R-HSA-8953897	Cellular responses to stimuli
R-HSA-4085377	SUMOylation of SUMOylation proteins	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-450520	HuR (ELAVL1) binds and stabilizes mRNA	Leaf	R-HSA-8953854	Metabolism of RNA
R-HSA-4551638	SUMOylation of chromatin organization proteins	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-4570464	SUMOylation of RNA binding proteins	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-4615885	SUMOylation of DNA replication proteins	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-5578749	Transcriptional regulation by small RNAs	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-5619107	Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	Leaf	R-HSA-1643685	Disease
R-HSA-6784531	tRNA processing in the nucleus	Leaf	R-HSA-8953854	Metabolism of RNA
R-HSA-9609690	HCMV Early Events	Leaf	R-HSA-1643685	Disease
R-HSA-9610379	HCMV Late Events	Leaf	R-HSA-1643685	Disease
R-HSA-9705671	SARS-CoV-2 activates/modulates innate and adaptive immune responses	Leaf	R-HSA-1643685	Disease

Subcellular location

Location	ECO term	Pubmed
Nucleus, nuclear pore complex	ECO:0000269	PubMed:8108440

Interactor | Variant | Drug

Phenotype

HPO ID	HPO name
HP:0000006	Autosomal dominant inheritance
HP:0000007	Autosomal recessive inheritance
HP:0000252	Microcephaly
HP:0000961	Cyanosis
HP:0001250	Seizure
HP:0001251	Ataxia
HP:0001252	Hypotonia
HP:0001257	Spasticity
HP:0001263	Global developmental delay
HP:0001272	Cerebellar atrophy
HP:0001276	Hypertonia
HP:0001290	Generalized hypotonia
HP:0001336	Myoclonus
HP:0001347	Hyperreflexia
HP:0001428	Somatic mutation
HP:0001508	Failure to thrive
HP:0001522	Death in infancy
HP:0002013	Vomiting
HP:0002020	Gastroesophageal reflux
HP:0002033	Poor suck
HP:0002059	Cerebral atrophy
HP:0002069	Bilateral tonic-clonic seizure
HP:0002098	Respiratory distress
HP:0002104	Apnea
HP:0002283	Global brain atrophy
HP:0002376	Developmental regression
HP:0002643	Neonatal respiratory distress
HP:0002783	Recurrent lower respiratory tract infections
HP:0002900	Hypokalemia
HP:0002902	Hyponatremia
HP:0003623	Neonatal onset
HP:0003676	Progressive
HP:0003819	Death in childhood
HP:0004808	Acute myeloid leukemia
HP:0006721	Acute lymphoblastic leukemia
HP:0010982	Polygenic inheritance
HP:0011968	Feeding difficulties
HP:0012510	Extra-axial cerebrospinal fluid accumulation
HP:0040213	Hypopnea

Tissue and cell type

Disease

Disease name	MONDO ID	ICD10	ICD10 chapter	OMIM	Orphanet
leukemia, acute lymphocytic, susceptibility to, 1	MONDO:0013108	C91	chapter2, Neoplasms	OMIM:613065
acute myeloid leukemia	MONDO:0018874	C92	chapter2, Neoplasms	OMIM:601626	Orphanet:519
encephalopathy, acute, infection-induced, susceptibility to, 9	MONDO:0032742	G93	chapter6, Diseases of the nervous system	OMIM:618426

Summary of P35658

Gene: NUP214, CAIN, CAN, KIAA0023
Protein: Nuclear pore complex protein Nup214

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of P35658

Gene: NUP214, CAIN, CAN, KIAA0023 Protein: Nuclear pore complex protein Nup214

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: NUP214, CAIN, CAN, KIAA0023
Protein: Nuclear pore complex protein Nup214