MultifacetedProtDB - Bologna Biocomputing Group

PDB	Resolution (Å)	PDB name
3SHW	2.9	Crystal structure of ZO-1 PDZ3-SH3-Guk supramodule complex with Connexin-45 peptide

GO ontology	GO term	GO description
Biological Process	GO:0086053	AV node cell to bundle of His cell communication by electrical coupling
Biological Process	GO:0086021	SA node cell to atrial cardiac muscle cell communication by electrical coupling
Biological Process	GO:0086014	atrial cardiac muscle cell action potential
Biological Process	GO:0048738	cardiac muscle tissue development
Biological Process	GO:0048468	cell development
Biological Process	GO:0007043	cell-cell junction assembly
Biological Process	GO:0007267	cell-cell signaling
Biological Process	GO:0007268	chemical synaptic transmission
Biological Process	GO:0016264	gap junction assembly
Biological Process	GO:0006936	muscle contraction
Biological Process	GO:0001570	vasculogenesis
Biological Process	GO:0007601	visual perception
Molecular Function	GO:0005243	gap junction channel activity
Molecular Function	GO:0086077	gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling
Molecular Function	GO:0086020	gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling
Molecular Function	GO:0005216	monoatomic ion channel activity
Cellular Component	GO:0005922	connexin complex
Cellular Component	GO:0005789	endoplasmic reticulum membrane
Cellular Component	GO:0005921	gap junction
Cellular Component	GO:0014704	intercalated disc
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0045202	synapse

InterPro	InterPro name
IPR000500	Connexin
IPR002265	Gap junction alpha-6 protein (Cx45)
IPR013092	Connexin, N-terminal
IPR017990	Connexin, conserved site
IPR019570	Gap junction protein, cysteine-rich domain
IPR038359	Connexin, N-terminal domain superfamily

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-112303	Electric Transmission Across Gap Junctions	Leaf	R-HSA-112316	Neuronal System
R-HSA-190861	Gap junction assembly	Internal node	R-HSA-5653656	Vesicle-mediated transport

Location	ECO term	Pubmed
Cell junction, gap junction
Cell membrane