Structure
| PDB | Resolution (Å) | PDB name |
|---|---|---|
| 1IRY | Solution structure of the hMTH1, a nucleotide pool sanitization enzyme | |
| 3Q93 | 1.8 | Crystal Structure of Human 8-oxo-dGTPase (MTH1) |
| 3WHW | 2.701 | MTH1 in complex with Ruthenium-based inhibitor |
| 3ZR0 | 1.8 | Crystal structure of human MTH1 in complex with 8-oxo-dGMP |
| 3ZR1 | 1.9 | Crystal structure of human MTH1 |
| 4C9W | 1.65 | Crystal structure of NUDT1 (MTH1) with R-crizotinib |
| 4C9X | 1.2 | Crystal structure of NUDT1 (MTH1) with S-crizotinib |
| 4N1T | 1.6 | Structure of human MTH1 in complex with TH287 |
| 4N1U | 1.6 | Structure of human MTH1 in complex with TH588 |
| 5ANS | 1.6 | Potent and selective inhibitors of MTH1 probe its role in cancer cell survival |
Showing 1 to 10 of 102 entries
GO term
GO ontology
| GO term | GO description |
|---|---|---|
| Biological Process | GO:0042262 | DNA protection |
| Biological Process | GO:0006281 | DNA repair |
| Biological Process | GO:0007568 | aging |
| Biological Process | GO:0008584 | male gonad development |
| Biological Process | GO:0006152 | purine nucleoside catabolic process |
| Biological Process | GO:0046686 | response to cadmium ion |
| Biological Process | GO:0006979 | response to oxidative stress |
| Cellular Component | GO:0001669 | acrosomal vesicle |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
Showing 1 to 10 of 27 entries
Reactome
| Reactome
| Reactome Name | Node type
| Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-2393930 | Phosphate bond hydrolysis by NUDT proteins | Leaf | R-HSA-1430728 | Metabolism |
Showing 1 to 1 of 1 entries
Subcellular location
| Location
| ECO term
| Pubmed |
|---|---|---|
| Cytoplasm, cytosol | ECO:0000269 | PubMed:12857738 |
| Cytoplasm, cytosol | ECO:0000269 | PubMed:16607562 |
| Cytoplasm, cytosol | ECO:0000269 | PubMed:7782328 |
| Mitochondrion matrix | ECO:0000269 | PubMed:12857738 |
| Mitochondrion matrix | ECO:0000269 | PubMed:16607562 |
| Mitochondrion matrix | ECO:0000269 | PubMed:7782328 |
| Nucleus | ECO:0000269 | PubMed:12857738 |
| Nucleus | ECO:0000269 | PubMed:7782328 |
Showing 1 to 8 of 8 entries
Interactor | Variant | Drug
Tissue and cell type
| Tissue
| Cell type
| Expression level | Reliability |
|---|---|---|---|
| adipose tissue | adipocytes | Low | Approved |
| adrenal gland | glandular cells | Medium | Approved |
| appendix | glandular cells | High | Approved |
| appendix | lymphoid tissue | Low | Approved |
| bone marrow | hematopoietic cells | Low | Approved |
| breast | glandular cells | Low | Approved |
| bronchus | ciliated cells (cilia axoneme) | High | Approved |
| bronchus | ciliated cells (tip of cilia) | High | Approved |
| caudate | neuronal cells | Low | Approved |
| cerebellum | Purkinje cells | Low | Approved |
Showing 1 to 10 of 70 entries