MultifacetedProtDB - Bologna Biocomputing Group

EC number	EC number description
3.1.3.16	Hydrolases; Acting on ester bonds; Phosphoric-monoester hydrolases; protein-serine/threonine phosphatase

Structure

PDB	Resolution (Å)	PDB name
1IT6	2.0	CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN CALYCULIN A AND THE CATALYTIC SUBUNIT OF PROTEIN PHOSPHATASE 1
1JK7	1.9	CRYSTAL STRUCTURE OF THE TUMOR-PROMOTER OKADAIC ACID BOUND TO PROTEIN PHOSPHATASE-1
1U32	2.0	Crystal structure of a Protein Phosphatase-1: Calcineurin Hybrid Bound to Okadaic Acid
2BCD	2.1	X-ray crystal structure of Protein Phosphatase-1 with the marine toxin motuporin bound
2BDX	2.3	X-ray Crystal Structure of dihydromicrocystin-LA bound to Protein Phosphatase-1
4UT2	1.96	X-ray structure of the human PP1 gamma catalytic subunit treated with ascorbate
4UT3	2.19	X-ray structure of the human PP1 gamma catalytic subunit treated with hydrogen peroxide
5INB	1.3	RepoMan-PP1g (protein phosphatase 1, gamma isoform) holoenzyme complex
5J28	2.0	Ki67-PP1g (protein phosphatase 1, gamma isoform) holoenzyme complex
7SD0	2.95	Cryo-EM structure of the SHOC2:PP1C:MRAS complex

GO term

GO ontology	GO term	GO description
Biological Process	GO:0000165	MAPK cascade
Biological Process	GO:0007049	cell cycle
Biological Process	GO:0051301	cell division
Biological Process	GO:0032922	circadian regulation of gene expression
Biological Process	GO:0043153	entrainment of circadian clock by photoperiod
Biological Process	GO:0005977	glycogen metabolic process
Biological Process	GO:0030182	neuron differentiation
Biological Process	GO:0060252	positive regulation of glial cell proliferation
Biological Process	GO:0006470	protein dephosphorylation
Biological Process	GO:0042752	regulation of circadian rhythm
Biological Process	GO:0046822	regulation of nucleocytoplasmic transport
Molecular Function	GO:0003723	RNA binding
Molecular Function	GO:0005521	lamin binding
Molecular Function	GO:0046872	metal ion binding
Molecular Function	GO:0017018	myosin phosphatase activity
Molecular Function	GO:0016791	phosphatase activity
Molecular Function	GO:0004721	phosphoprotein phosphatase activity
Molecular Function	GO:0019904	protein domain specific binding
Molecular Function	GO:0019901	protein kinase binding
Molecular Function	GO:0008157	protein phosphatase 1 binding
Molecular Function	GO:0004722	protein serine/threonine phosphatase activity
Molecular Function	GO:0044877	protein-containing complex binding
Cellular Component	GO:0072357	PTW/PP1 phosphatase complex
Cellular Component	GO:0032154	cleavage furrow
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005856	cytoskeleton
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0043197	dendritic spine
Cellular Component	GO:0005925	focal adhesion
Cellular Component	GO:0098978	glutamatergic synapse
Cellular Component	GO:0000776	kinetochore
Cellular Component	GO:0030496	midbody
Cellular Component	GO:0005741	mitochondrial outer membrane
Cellular Component	GO:0005739	mitochondrion
Cellular Component	GO:0016607	nuclear speck
Cellular Component	GO:0005730	nucleolus
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0098793	presynapse
Cellular Component	GO:0032991	protein-containing complex

InterPro	InterPro name
IPR004843	Calcineurin-like phosphoesterase domain, ApaH type
IPR006186	Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
IPR029052	Metallo-dependent phosphatase-like
IPR031675	Serine-threonine protein phosphatase, N-terminal

Pfam	Pfam name
PF00149	Calcineurin-like phosphoesterase
PF16891	Serine-threonine protein phosphatase N-terminal domain

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-141444	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-163560	Triglyceride catabolism	Leaf	R-HSA-1430728	Metabolism
R-HSA-2173788	Downregulation of TGF-beta receptor signaling	Leaf	R-HSA-162582	Signal Transduction
R-HSA-2467813	Separation of Sister Chromatids	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-2500257	Resolution of Sister Chromatid Cohesion	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-400253	Circadian Clock	Root	R-HSA-400253	Circadian Clock
R-HSA-5663220	RHO GTPases Activate Formins	Leaf	R-HSA-162582	Signal Transduction
R-HSA-5673000	RAF activation	Leaf	R-HSA-162582	Signal Transduction
R-HSA-68877	Mitotic Prometaphase	Internal node	R-HSA-1640170	Cell Cycle
R-HSA-9648025	EML4 and NUDC in mitotic spindle formation	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-9726840	SHOC2 M1731 mutant abolishes MRAS complex function	Leaf	R-HSA-1643685	Disease
R-HSA-9726842	Gain-of-function MRAS complexes activate RAF signaling	Leaf	R-HSA-1643685	Disease

Location	ECO term	Pubmed
Chromosome, centromere, kinetochore	ECO:0000269	PubMed:12529430
Cleavage furrow	ECO:0000269	PubMed:12529430
Cytoplasm	ECO:0000269	PubMed:11739654
Cytoplasm, cytoskeleton, microtubule organizing center	ECO:0000269	PubMed:23789093
Midbody	ECO:0000269	PubMed:12529430
Mitochondrion	ECO:0000269	PubMed:17936702
Nucleus
Nucleus speckle	ECO:0000269	PubMed:11739654
Nucleus, nucleolus	ECO:0000269	PubMed:11739654
Nucleus, nucleolus	ECO:0000269	PubMed:20926688
Nucleus, nucleolus	ECO:0000269	PubMed:23789093
Nucleus, nucleoplasm	ECO:0000269	PubMed:11739654

Summary of P36873

Gene: PPP1CC
Protein: Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of P36873

Gene: PPP1CC Protein: Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: PPP1CC
Protein: Serine/threonine-protein phosphatase PP1-gamma catalytic subunit