Protein family
Protein sequence
Protein function
Catalytic activity
EC number
EC number description
1.11.1.12
Oxidoreductases;
Acting on a peroxide as acceptor;
Peroxidases;
phospholipid-hydroperoxide glutathione peroxidase
PDB | Resolution (Å) | PDB name |
---|---|---|
2GS3 | 1.9 | Crystal structure of the selenocysteine to glycine mutant of human glutathione peroxidase 4(GPX4) |
2OBI | 1.55 | Crystal structure of the Selenocysteine to Cysteine Mutant of human phospholipid hydroperoxide glutathione peroxidase (GPx4) |
5H5Q | 1.1 | Crystal structure of human GPX4 in complex with GXpep-1 |
5H5R | 1.2 | Crystal structure of human GPX4 in complex with GXpep-2 |
5H5S | 1.85 | Crystal structure of human GPX4 in complex with GXpep-3 |
6ELW | 1.3 | High resolution structure of selenocysteine containing human GPX4 |
6HKQ | 1.54 | Human GPX4 in complex with covalent Inhibitor ML162 (S enantiomer) |
6HN3 | 1.01 | wildtype form (apo) of human GPX4 with Se-Cys46 |
7L8K | 1.38 | Crystal structure of human GPX4-U46C |
7L8L | 1.61 | Crystal structure of human R152H GPX4-U46C |
7L8M | 2.07 | Crystal structure of human GPX4-U46C mutant K48L |
7L8Q | 1.48 | Crystal structure of human GPX4-U46C with oxidized Cys-46 |
7L8R | 1.52 | Crystal structure of human GPX4-U46C mutant K48A |
7U4I | 1.97 | Crystal structure of human GPX4-U46C-R152H in complex with CDS9 |
7U4J | 1.81 | Crystal structure of human GPX4-U46C-R152H in complex with TMT10 |
7U4K | 1.69 | Crystal structure of human GPX4-U46C-R152H in complex with ML162 |
7U4L | 2.25 | Crystal structure of human GPX4-U46C in complex with MAC-5576 |
7U4M | 1.93 | Crystal structure of human GPX4-U46C in complex with LOC1886 |
7U4N | 1.6 | Crystal structure of human GPX4-U46C in complex with RSL3 |
GO ontology | GO term | GO description |
---|---|---|
Biological Process | GO:0007568 | aging |
Biological Process | GO:0019369 | arachidonic acid metabolic process |
Biological Process | GO:0006325 | chromatin organization |
Biological Process | GO:0006749 | glutathione metabolic process |
Biological Process | GO:0019372 | lipoxygenase pathway |
Biological Process | GO:0042759 | long-chain fatty acid biosynthetic process |
Biological Process | GO:0110076 | negative regulation of ferroptosis |
Biological Process | GO:0006644 | phospholipid metabolic process |
Biological Process | GO:0051258 | protein polymerization |
Biological Process | GO:0050727 | regulation of inflammatory response |
Biological Process | GO:0032355 | response to estradiol |
Biological Process | GO:0006979 | response to oxidative stress |
Biological Process | GO:0007283 | spermatogenesis |
Molecular Function | GO:0004602 | glutathione peroxidase activity |
Molecular Function | GO:0042802 | identical protein binding |
Molecular Function | GO:0004601 | peroxidase activity |
Molecular Function | GO:0047066 | phospholipid-hydroperoxide glutathione peroxidase activity |
Molecular Function | GO:0008430 | selenium binding |
Cellular Component | GO:0005829 | cytosol |
Cellular Component | GO:0070062 | extracellular exosome |
Cellular Component | GO:0005739 | mitochondrion |
Cellular Component | GO:0005635 | nuclear envelope |
Cellular Component | GO:0005634 | nucleus |
Cellular Component | GO:0032991 | protein-containing complex |
Reactome | Reactome Name | Node type | Reactome Root | Reactome Root Name |
---|---|---|---|---|
R-HSA-2142688 | Synthesis of 5-eicosatetraenoic acids | Leaf | R-HSA-1430728 | Metabolism |
R-HSA-2142712 | Synthesis of 12-eicosatetraenoic acid derivatives | Leaf | R-HSA-1430728 | Metabolism |
R-HSA-2142770 | Synthesis of 15-eicosatetraenoic acid derivatives | Leaf | R-HSA-1430728 | Metabolism |
R-HSA-9018676 | Biosynthesis of D-series resolvins | Leaf | R-HSA-1430728 | Metabolism |
R-HSA-9018896 | Biosynthesis of E-series 18(S)-resolvins | Leaf | R-HSA-1430728 | Metabolism |
R-HSA-9020265 | Biosynthesis of aspirin-triggered D-series resolvins | Leaf | R-HSA-1430728 | Metabolism |
R-HSA-9023661 | Biosynthesis of E-series 18(R)-resolvins | Leaf | R-HSA-1430728 | Metabolism |
Location | ECO term | Pubmed |
---|---|---|
Cytoplasm | ECO:0000269 | PubMed:11115402 |
Mitochondrion | ECO:0000250 |
HPO ID | HPO name |
---|---|
HP:0000007 | Autosomal recessive inheritance |
HP:0000262 | Turricephaly |
HP:0000358 | Posteriorly rotated ears |
HP:0000470 | Short neck |
HP:0000772 | Abnormal rib morphology |
HP:0000773 | Short ribs |
HP:0000774 | Narrow chest |
HP:0000782 | Abnormal scapula morphology |
HP:0000878 | 11 pairs of ribs |
HP:0000887 | Cupped ribs |
HP:0000926 | Platyspondyly |
HP:0001156 | Brachydactyly |
HP:0001252 | Hypotonia |
HP:0001274 | Agenesis of corpus callosum |
HP:0001290 | Generalized hypotonia |
HP:0001302 | Pachygyria |
HP:0001321 | Cerebellar hypoplasia |
HP:0001582 | Redundant skin |
HP:0001631 | Atrial septal defect |
HP:0001678 | Atrioventricular block |
HP:0001762 | Talipes equinovarus |
HP:0001831 | Short toe |
HP:0002093 | Respiratory insufficiency |
HP:0002132 | Porencephalic cyst |
HP:0002657 | Spondylometaphyseal dysplasia |
HP:0002663 | Delayed epiphyseal ossification |
HP:0002750 | Delayed skeletal maturation |
HP:0002869 | Flared iliac wing |
HP:0003021 | Metaphyseal cupping |
HP:0003025 | Metaphyseal irregularity |
HP:0003026 | Short long bone |
HP:0003085 | Long fibula |
HP:0003180 | Flat acetabular roof |
HP:0003375 | Narrow greater sciatic notch |
HP:0003498 | Disproportionate short stature |
HP:0004279 | Short palm |
HP:0004491 | Large posterior fontanelle |
HP:0004688 | Irregular tarsal bones |
HP:0004991 | Rhizomelic arm shortening |
HP:0005280 | Depressed nasal bridge |
HP:0005616 | Accelerated skeletal maturation |
HP:0005871 | Metaphyseal chondrodysplasia |
HP:0006059 | Cone-shaped metacarpal epiphyses |
HP:0006543 | Cardiorespiratory arrest |
HP:0007187 | Focal lissencephaly |
HP:0008786 | Iliac crest serration |
HP:0008798 | Widened greater sciatic notch |
HP:0008905 | Rhizomelia |
HP:0009381 | Short finger |
HP:0009803 | Short phalanx of finger |
HP:0010049 | Short metacarpal |
HP:0010230 | Cone-shaped epiphyses of the phalanges of the hand |
HP:0010579 | Cone-shaped epiphysis |
HP:0011675 | Arrhythmia |
HP:0012819 | Myocarditis |
HP:0031233 | Horizontal inferior border of scapula |
Disease name | MONDO ID | ICD10 | ICD10 chapter | OMIM | Orphanet |
---|---|---|---|---|---|
spondylometaphyseal dysplasia, sedaghatian type | MONDO:0009593 | Q77 | chapter17, Congenital malformations, deformations and chromosomal abnormalities | OMIM:250220 | Orphanet:93317 |