Protein family
The protein has not catalytic activity
Protein sequence
Protein function
Catalytic activity
PDB | Resolution (Å) | PDB name |
---|---|---|
4UG0 | 3.6 | STRUCTURE OF THE HUMAN 80S RIBOSOME |
4V6X | 5.0 | Structure of the human 80S ribosome |
5AJ0 | 3.5 | Cryo electron microscopy of actively translating human polysomes (POST state). |
5LKS | 3.6 | Structure-function insights reveal the human ribosome as a cancer target for antibiotics |
5T2C | 3.6 | CryoEM structure of the human ribosome at 3.6 Angstrom resolution |
6IP5 | 3.9 | Cryo-EM structure of the CMV-stalled human 80S ribosome (Structure ii) |
6IP6 | 4.5 | Cryo-EM structure of the CMV-stalled human 80S ribosome with HCV IRES (Structure iii) |
6IP8 | 3.9 | Cryo-EM structure of the HCV IRES dependently initiated CMV-stalled 80S ribosome (Structure iv) |
6LQM | 3.09 | Cryo-EM structure of a pre-60S ribosomal subunit - state C |
6LSR | 3.13 | Cryo-EM structure of a pre-60S ribosomal subunit - state B |
6LSS | 3.23 | Cryo-EM structure of a pre-60S ribosomal subunit - state preA |
6LU8 | 3.13 | Cryo-EM structure of a human pre-60S ribosomal subunit - state A |
6OLE | 3.1 | Human ribosome nascent chain complex (CDH1-RNC) stalled by a drug-like molecule with AP and PE tRNAs |
6OLF | 3.9 | Human ribosome nascent chain complex (CDH1-RNC) stalled by a drug-like molecule with AA and PE tRNAs |
6OLG | 3.4 | Human ribosome nascent chain complex stalled by a drug-like small molecule (CDH1_RNC with PP tRNA) |
6OLI | 3.5 | Structure of human ribosome nascent chain complex selectively stalled by a drug-like small molecule (USO1-RNC) |
6OLZ | 3.9 | Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like molecule with PP tRNA |
6OM0 | 3.1 | Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like molecule with AP and PE tRNAs |
6OM7 | 3.7 | Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like small molecule with AA and PE tRNAs |
6QZP | 2.9 | High-resolution cryo-EM structure of the human 80S ribosome |
6W6L | 3.84 | Cryo-EM structure of the human ribosome-TMCO1 translocon |
6XA1 | 2.8 | Structure of a drug-like compound stalled human translation termination complex |
6Y0G | 3.2 | Structure of human ribosome in classical-PRE state |
6Y2L | 3.0 | Structure of human ribosome in POST state |
6Y57 | 3.5 | Structure of human ribosome in hybrid-PRE state |
6Y6X | 2.8 | Tetracenomycin X bound to the human ribosome |
6Z6L | 3.0 | Cryo-EM structure of human CCDC124 bound to 80S ribosomes |
6Z6M | 3.1 | Cryo-EM structure of human 80S ribosomes bound to EBP1, eEF2 and SERBP1 |
6Z6N | 2.9 | Cryo-EM structure of human EBP1-80S ribosomes (focus on EBP1) |
6ZM7 | 2.7 | SARS-CoV-2 Nsp1 bound to the human CCDC124-80S-EBP1 ribosome complex |
6ZME | 3.0 | SARS-CoV-2 Nsp1 bound to the human CCDC124-80S-eERF1 ribosome complex |
6ZMI | 2.6 | SARS-CoV-2 Nsp1 bound to the human LYAR-80S ribosome complex |
6ZMO | 3.1 | SARS-CoV-2 Nsp1 bound to the human LYAR-80S-eEF1a ribosome complex |
7BHP | 3.3 | Cryo-EM structure of the human Ebp1 - 80S ribosome |
7F5S | 2.72 | human delta-METTL18 60S ribosome |
7OW7 | 2.4 | EIF6-bound large subunit of the human ribosome |
7QVP | 3.0 | Human collided disome (di-ribosome) stalled on XBP1 mRNA |
8A3D | 1.67 | Human mature large subunit of the ribosome with eIF6 and homoharringtonine bound |
GO ontology | GO term | GO description |
---|---|---|
Biological Process | GO:0071346 | cellular response to type II interferon |
Biological Process | GO:0002181 | cytoplasmic translation |
Biological Process | GO:0042592 | homeostatic process |
Biological Process | GO:0060425 | lung morphogenesis |
Biological Process | GO:0048246 | macrophage chemotaxis |
Biological Process | GO:1901194 | negative regulation of formation of translation preinitiation complex |
Biological Process | GO:0017148 | negative regulation of translation |
Biological Process | GO:0032496 | response to lipopolysaccharide |
Biological Process | GO:0006412 | translation |
Molecular Function | GO:0003723 | RNA binding |
Molecular Function | GO:0003729 | mRNA binding |
Molecular Function | GO:0003735 | structural constituent of ribosome |
Cellular Component | GO:0097452 | GAIT complex |
Cellular Component | GO:0005737 | cytoplasm |
Cellular Component | GO:0005829 | cytosol |
Cellular Component | GO:0022625 | cytosolic large ribosomal subunit |
Cellular Component | GO:0022626 | cytosolic ribosome |
Cellular Component | GO:0005925 | focal adhesion |
Cellular Component | GO:0015934 | large ribosomal subunit |
Cellular Component | GO:0016020 | membrane |
Cellular Component | GO:0005730 | nucleolus |
Cellular Component | GO:0005634 | nucleus |
Cellular Component | GO:1990904 | ribonucleoprotein complex |
Cellular Component | GO:0005840 | ribosome |
Cellular Component | GO:0045202 | synapse |
Reactome | Reactome Name | Node type | Reactome Root | Reactome Root Name |
---|---|---|---|---|
R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | Leaf | R-HSA-392499 | Metabolism of proteins |
R-HSA-156902 | Peptide chain elongation | Leaf | R-HSA-392499 | Metabolism of proteins |
R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | Leaf | R-HSA-392499 | Metabolism of proteins |
R-HSA-192823 | Viral mRNA Translation | Leaf | R-HSA-1643685 | Disease |
R-HSA-2408557 | Selenocysteine synthesis | Leaf | R-HSA-1430728 | Metabolism |
R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | Leaf | R-HSA-8953854 | Metabolism of RNA |
R-HSA-72689 | Formation of a pool of free 40S subunits | Leaf | R-HSA-392499 | Metabolism of proteins |
R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | Leaf | R-HSA-392499 | Metabolism of proteins |
R-HSA-72764 | Eukaryotic Translation Termination | Leaf | R-HSA-392499 | Metabolism of proteins |
R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | Leaf | R-HSA-1266738 | Developmental Biology |
R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | Leaf | R-HSA-8953897 | Cellular responses to stimuli |
R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | Leaf | R-HSA-8953854 | Metabolism of RNA |
R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | Leaf | R-HSA-8953854 | Metabolism of RNA |
Location | ECO term | Pubmed |
---|---|---|
Cytoplasm | ECO:0000305 | PubMed:14567916 |
Cytoplasm | ECO:0000305 | PubMed:23636399 |