MultifacetedProtDB - Bologna Biocomputing Group

Summary of P41238

Gene: APOBEC1
Protein: C->U-editing enzyme APOBEC-1

Protein family
Protein sequence
Protein function

Catalytic activity

EC number	EC number description
3.5.4.-	Hydrolases; Acting on carbon-nitrogen bonds, other than peptide bonds; In cyclic amidines;
3.5.4.36	Hydrolases; Acting on carbon-nitrogen bonds, other than peptide bonds; In cyclic amidines; mRNA(cytosine6666) deaminase

Publications

Structure

PDB	Resolution (Å)	PDB name
6X91	3.51	Crystal structure of MBP-fused human APOBEC1

GO term

GO ontology	GO term	GO description
Biological Process	GO:0080111	DNA demethylation
Biological Process	GO:0016554	cytidine to uridine editing
Biological Process	GO:0051649	establishment of localization in cell
Biological Process	GO:0006629	lipid metabolic process
Biological Process	GO:0042158	lipoprotein biosynthetic process
Biological Process	GO:0042953	lipoprotein transport
Biological Process	GO:0016556	mRNA modification
Biological Process	GO:0006397	mRNA processing
Biological Process	GO:0048255	mRNA stabilization
Biological Process	GO:0090310	negative regulation of DNA methylation-dependent heterochromatin formation
Biological Process	GO:2000623	negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
Biological Process	GO:0090209	negative regulation of triglyceride metabolic process
Biological Process	GO:1901537	positive regulation of DNA demethylation
Biological Process	GO:0042127	regulation of cell population proliferation
Biological Process	GO:0010332	response to gamma radiation
Biological Process	GO:0006641	triglyceride metabolic process
Molecular Function	GO:0003723	RNA binding
Molecular Function	GO:0140098	catalytic activity, acting on RNA
Molecular Function	GO:0004126	cytidine deaminase activity
Molecular Function	GO:0035925	mRNA 3'-UTR AU-rich region binding
Molecular Function	GO:0008270	zinc ion binding
Cellular Component	GO:0030895	apolipoprotein B mRNA editing enzyme complex
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0045293	mRNA editing complex
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus

InterPro	InterPro name
IPR002125	Cytidine and deoxycytidylate deaminase domain
IPR016192	APOBEC/CMP deaminase, zinc-binding
IPR016193	Cytidine deaminase-like
IPR041547	C->U-editing enzyme APOBEC-1

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-72200	mRNA Editing: C to U Conversion	Internal node	R-HSA-8953854	Metabolism of RNA
R-HSA-75094	Formation of the Editosome	Leaf	R-HSA-8953854	Metabolism of RNA

Location	ECO term	Pubmed
Cytoplasm	ECO:0000269	PubMed:22580899
Nucleus	ECO:0000269	PubMed:24916387

Summary of P41238

Gene: APOBEC1
Protein: C->U-editing enzyme APOBEC-1

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of P41238

Gene: APOBEC1 Protein: C->U-editing enzyme APOBEC-1

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: APOBEC1
Protein: C->U-editing enzyme APOBEC-1