Protein family
Protein sequence
Protein function
Catalytic activity
EC number
EC number description
2.7.7.-
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases;
6.1.1.14
Ligases;
Forming carbon-oxygen bonds;
Ligases forming aminoacyl-tRNA and related compounds;
glycine—tRNA ligase
PDB | Resolution (Å) | PDB name |
---|---|---|
2PME | 2.9 | The Apo crystal Structure of the glycyl-tRNA synthetase |
2PMF | 2.85 | The crystal structure of a human glycyl-tRNA synthetase mutant |
2Q5H | 3.0 | Crystal structure of apo-wildtype Glycyl-tRNA synthetase |
2Q5I | 2.8 | Crystal structure of apo S581L Glycyl-tRNA synthetase mutant |
2ZT5 | 2.5 | Crystal structure of human glycyl-trna synthetase (GLYRS) in complex with AP4A (cocrystallized with ATP) |
2ZT6 | 3.08 | Crystal structure of human Glycyl-tRNA synthetase (GlyRS) in complex with AMPCPP |
2ZT7 | 2.7 | Crystal structure of human Glycyl-tRNA synthetase (GlyRS) in complex with Glycine and ATP |
2ZT8 | 3.35 | Crystal structure of human Glycyl-tRNA synthetase (GlyRS) in complex with Gly-AMP analog |
2ZXF | 3.4 | Crystal structure of human glycyl-trna synthetase (GLYRS) in complex with AP4A (cocrystallized with AP4A) |
4KQE | 2.739 | The mutant structure of the human glycyl-tRNA synthetase E71G |
4KR2 | 3.292 | Glycyl-tRNA synthetase in complex with tRNA-Gly |
4KR3 | 3.235 | Glycyl-tRNA synthetase mutant E71G in complex with tRNA-Gly |
4QEI | 2.875 | Two distinct conformational states of GlyRS captured in crystal lattice |
5E6M | 2.927 | Crystal structure of human wild type GlyRS bound with tRNAGly |
GO ontology | GO term | GO description |
---|---|---|
Biological Process | GO:0015966 | diadenosine tetraphosphate biosynthetic process |
Biological Process | GO:0070150 | mitochondrial glycyl-tRNA aminoacylation |
Biological Process | GO:0006418 | tRNA aminoacylation for protein translation |
Molecular Function | GO:0005524 | ATP binding |
Molecular Function | GO:0004081 | bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity |
Molecular Function | GO:0004820 | glycine-tRNA ligase activity |
Molecular Function | GO:0042802 | identical protein binding |
Molecular Function | GO:0046983 | protein dimerization activity |
Molecular Function | GO:0016740 | transferase activity |
Cellular Component | GO:0030424 | axon |
Cellular Component | GO:0005737 | cytoplasm |
Cellular Component | GO:0005829 | cytosol |
Cellular Component | GO:0070062 | extracellular exosome |
Cellular Component | GO:0005759 | mitochondrial matrix |
Cellular Component | GO:0005739 | mitochondrion |
Cellular Component | GO:0030141 | secretory granule |
InterPro | InterPro name |
---|---|
IPR000738 | WHEP-TRS domain |
IPR002314 | Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) |
IPR002315 | Glycyl-tRNA synthetase |
IPR004154 | Anticodon-binding |
IPR006195 | Aminoacyl-tRNA synthetase, class II |
IPR009068 | S15/NS1, RNA-binding |
IPR027031 | Glycyl-tRNA synthetase/DNA polymerase subunit gamma-2 |
IPR033731 | Glycyl-tRNA synthetase-like core domain |
IPR036621 | Anticodon-binding domain superfamily |
IPR045864 | Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL) |
Pfam | Pfam name |
---|---|
PF00458 | WHEP-TRS domain |
PF00587 | tRNA synthetase class II core domain (G, H, P, S and T) |
PF03129 | Anticodon binding domain |
Reactome | Reactome Name | Node type | Reactome Root | Reactome Root Name |
---|---|---|---|---|
R-HSA-379716 | Cytosolic tRNA aminoacylation | Leaf | R-HSA-392499 | Metabolism of proteins |
R-HSA-379726 | Mitochondrial tRNA aminoacylation | Leaf | R-HSA-392499 | Metabolism of proteins |
Location | ECO term | Pubmed |
---|---|---|
Cell projection, axon | ECO:0000269 | PubMed:17035524 |
Cell projection, axon | ECO:0000269 | PubMed:25168514 |
Cytoplasm | ECO:0000269 | PubMed:17035524 |
Cytoplasm | ECO:0000269 | PubMed:17529987 |
Cytoplasm | ECO:0000269 | PubMed:26327585 |
Mitochondrion | ECO:0000269 | PubMed:17529987 |
Mitochondrion | ECO:0000269 | PubMed:26327585 |
Secreted | ECO:0000250 | |
Secreted, extracellular exosome | ECO:0000250 |
HPO ID | HPO name |
---|---|
HP:0000006 | Autosomal dominant inheritance |
HP:0001265 | Hyporeflexia |
HP:0001270 | Motor delay |
HP:0001284 | Areflexia |
HP:0001290 | Generalized hypotonia |
HP:0001324 | Muscle weakness |
HP:0001347 | Hyperreflexia |
HP:0001621 | Weak voice |
HP:0001761 | Pes cavus |
HP:0001763 | Pes planus |
HP:0001765 | Hammertoe |
HP:0002093 | Respiratory insufficiency |
HP:0002172 | Postural instability |
HP:0002317 | Unsteady gait |
HP:0002460 | Distal muscle weakness |
HP:0002495 | Impaired vibratory sensation |
HP:0002650 | Scoliosis |
HP:0002936 | Distal sensory impairment |
HP:0002938 | Lumbar hyperlordosis |
HP:0003273 | Hip contracture |
HP:0003392 | First dorsal interossei muscle weakness |
HP:0003393 | Thenar muscle atrophy |
HP:0003426 | First dorsal interossei muscle atrophy |
HP:0003427 | Thenar muscle weakness |
HP:0003435 | Cold-induced hand cramps |
HP:0003484 | Upper limb muscle weakness |
HP:0003557 | Increased variability in muscle fiber diameter |
HP:0003593 | Infantile onset |
HP:0003677 | Slowly progressive |
HP:0003693 | Distal amyotrophy |
HP:0003803 | Type 1 muscle fiber predominance |
HP:0004322 | Short stature |
HP:0007178 | Motor polyneuropathy |
HP:0007340 | Lower limb muscle weakness |
HP:0008081 | Pes valgus |
HP:0009053 | Distal lower limb muscle weakness |
HP:0009129 | Upper limb amyotrophy |
HP:0009830 | Peripheral neuropathy |
HP:0010546 | Muscle fibrillation |
HP:0011462 | Young adult onset |
HP:0031936 | Delayed ability to walk |
HP:0040131 | Abnormal motor nerve conduction velocity |
Disease name | MONDO ID | ICD10 | ICD10 chapter | OMIM | Orphanet |
---|---|---|---|---|---|
charcot-marie-tooth disease type 2d | MONDO:0011091 | G60 | chapter6, Diseases of the nervous system | OMIM:601472 | Orphanet:99938 |
neuronopathy, distal hereditary motor, type 5a | MONDO:0015353 | G12 | chapter6, Diseases of the nervous system | OMIM:600794 | |
spinal muscular atrophy- infantile- james type | MONDO:0033621 | G12 | chapter6, Diseases of the nervous system | OMIM:619042 |