Protein family
Protein sequence
Protein function
Publications
Catalytic activity
EC number
EC number description
2.7.1.153
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor;
phosphatidylinositol-4,5-bisphosphate 3-kinase
2.7.11.1
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases;
non-specific serine/threonine protein kinase
| PDB | Resolution (Å) | PDB name |
|---|
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0007186 | G protein-coupled receptor signaling pathway |
| Biological Process | GO:0060055 | angiogenesis involved in wound healing |
| Biological Process | GO:0006914 | autophagy |
| Biological Process | GO:0016477 | cell migration |
| Biological Process | GO:0006935 | chemotaxis |
| Biological Process | GO:0040016 | embryonic cleavage |
| Biological Process | GO:0006897 | endocytosis |
| Biological Process | GO:0001935 | endothelial cell proliferation |
| Biological Process | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules |
| Biological Process | GO:0006874 | intracellular calcium ion homeostasis |
| Biological Process | GO:0043407 | negative regulation of MAP kinase activity |
| Biological Process | GO:1903298 | negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway |
| Biological Process | GO:0051898 | negative regulation of protein kinase B signaling |
| Biological Process | GO:1903671 | negative regulation of sprouting angiogenesis |
| Biological Process | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway |
| Biological Process | GO:0014065 | phosphatidylinositol 3-kinase signaling |
| Biological Process | GO:0046854 | phosphatidylinositol phosphate biosynthetic process |
| Biological Process | GO:0036092 | phosphatidylinositol-3-phosphate biosynthetic process |
| Biological Process | GO:0016310 | phosphorylation |
| Biological Process | GO:0030168 | platelet activation |
| Biological Process | GO:0070527 | platelet aggregation |
| Biological Process | GO:0035022 | positive regulation of Rac protein signal transduction |
| Biological Process | GO:0010508 | positive regulation of autophagy |
| Biological Process | GO:0010595 | positive regulation of endothelial cell migration |
| Biological Process | GO:0010628 | positive regulation of gene expression |
| Biological Process | GO:0033031 | positive regulation of neutrophil apoptotic process |
| Biological Process | GO:0051000 | positive regulation of nitric-oxide synthase activity |
| Biological Process | GO:0051897 | positive regulation of protein kinase B signaling |
| Biological Process | GO:0001952 | regulation of cell-matrix adhesion |
| Biological Process | GO:2000369 | regulation of clathrin-dependent endocytosis |
| Biological Process | GO:0002931 | response to ischemia |
| Biological Process | GO:0007165 | signal transduction |
| Biological Process | GO:0003376 | sphingosine-1-phosphate receptor signaling pathway |
| Biological Process | GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway |
| Molecular Function | GO:0016303 | 1-phosphatidylinositol-3-kinase activity |
| Molecular Function | GO:0035005 | 1-phosphatidylinositol-4-phosphate 3-kinase activity |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0043560 | insulin receptor substrate binding |
| Molecular Function | GO:0016301 | kinase activity |
| Molecular Function | GO:0035004 | phosphatidylinositol 3-kinase activity |
| Molecular Function | GO:0052812 | phosphatidylinositol-3,4-bisphosphate 5-kinase activity |
| Molecular Function | GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity |
| Molecular Function | GO:0106310 | protein serine kinase activity |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0043231 | intracellular membrane-bounded organelle |
| Cellular Component | GO:0030496 | midbody |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005942 | phosphatidylinositol 3-kinase complex |
| Cellular Component | GO:0005943 | phosphatidylinositol 3-kinase complex, class IA |
| Cellular Component | GO:0005886 | plasma membrane |
| InterPro
|
InterPro name |
|---|---|
| IPR000341 | Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain |
| IPR000403 | Phosphatidylinositol 3-/4-kinase, catalytic domain |
| IPR001263 | Phosphoinositide 3-kinase, accessory (PIK) domain |
| IPR002420 | C2 phosphatidylinositol 3-kinase-type domain |
| IPR003113 | Phosphatidylinositol 3-kinase, adaptor-binding domain |
| IPR011009 | Protein kinase-like domain superfamily |
| IPR015433 | Phosphatidylinositol kinase |
| IPR016024 | Armadillo-type fold |
| IPR018936 | Phosphatidylinositol 3/4-kinase, conserved site |
| IPR029071 | Ubiquitin-like domain superfamily |
| IPR035892 | C2 domain superfamily |
| IPR036940 | Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily |
| IPR037702 | PI3Kbeta, catalytic domain |
| IPR042236 | Phosphoinositide 3-kinase, accessory (PIK) domain superfamily |
| Pfam
|
Pfam name |
|---|---|
| PF00454 | Phosphatidylinositol 3- and 4-kinase |
| PF00613 | Phosphoinositide 3-kinase family, accessory domain (PIK domain) |
| PF00792 | Phosphoinositide 3-kinase C2 |
| PF00794 | PI3-kinase family, ras-binding domain |
| PF02192 | PI3-kinase family, p85-binding domain |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-109704 | PI3K Cascade | Internal node | R-HSA-162582 | Signal Transduction |
| R-HSA-112399 | IRS-mediated signalling | Internal node | R-HSA-162582 | Signal Transduction |
| R-HSA-114604 | GPVI-mediated activation cascade | Leaf | R-HSA-109582 | Hemostasis |
| R-HSA-1257604 | PIP3 activates AKT signaling | Internal node | R-HSA-162582 | Signal Transduction |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | Leaf | R-HSA-1430728 | Metabolism |
| R-HSA-186763 | Downstream signal transduction | Leaf | R-HSA-162582 | Signal Transduction |
| R-HSA-198203 | PI3K/AKT activation | Leaf | R-HSA-162582 | Signal Transduction |
| R-HSA-201556 | Signaling by ALK | Internal node | R-HSA-162582 | Signal Transduction |
| R-HSA-202424 | Downstream TCR signaling | Leaf | R-HSA-168256 | Immune System |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | Leaf | R-HSA-168256 | Immune System |
| R-HSA-210993 | Tie2 Signaling | Leaf | R-HSA-109582 | Hemostasis |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | Leaf | R-HSA-1643685 | Disease |
| R-HSA-2424491 | DAP12 signaling | Leaf | R-HSA-168256 | Immune System |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | Leaf | R-HSA-168256 | Immune System |
| R-HSA-373753 | Nephrin family interactions | Leaf | R-HSA-1500931 | Cell-Cell communication |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | Internal node | R-HSA-162582 | Signal Transduction |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | Internal node | R-HSA-168256 | Immune System |
| R-HSA-5673001 | RAF/MAP kinase cascade | Internal node | R-HSA-162582 | Signal Transduction |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | Leaf | R-HSA-162582 | Signal Transduction |
| R-HSA-8853659 | RET signaling | Leaf | R-HSA-1266738 | Developmental Biology |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | Leaf | R-HSA-162582 | Signal Transduction |
| R-HSA-912526 | Interleukin receptor SHC signaling | Leaf | R-HSA-168256 | Immune System |
| R-HSA-912631 | Regulation of signaling by CBL | Leaf | R-HSA-168256 | Immune System |
| R-HSA-9673767 | Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants | Leaf | R-HSA-1643685 | Disease |
| R-HSA-9673770 | Signaling by PDGFRA extracellular domain mutants | Leaf | R-HSA-1643685 | Disease |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | Leaf | R-HSA-168256 | Immune System |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Cytoplasm | ECO:0000269 | PubMed:21383062 |
| Nucleus | ECO:0000269 | PubMed:21383062 |
| HPO ID
|
HPO name |
|---|
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adrenal gland | glandular cells | Medium | Approved |
| appendix | glandular cells | Medium | Approved |
| appendix | lymphoid tissue | Medium | Approved |
| bone marrow | hematopoietic cells | Medium | Approved |
| breast | glandular cells | Medium | Approved |
| breast | myoepithelial cells | Medium | Approved |
| bronchus | respiratory epithelial cells | Medium | Approved |
| caudate | glial cells | Low | Approved |
| caudate | neuronal cells | Medium | Approved |
| cerebellum | Purkinje cells | Medium | Approved |
| cerebellum | cells in granular layer | Medium | Approved |
| cerebral cortex | endothelial cells | Low | Approved |
| cerebral cortex | glial cells | Medium | Approved |
| cerebral cortex | neuronal cells | Medium | Approved |
| cerebral cortex | neuropil | Medium | Approved |
| cervix | glandular cells | Low | Approved |
| cervix | squamous epithelial cells | Medium | Approved |
| colon | endothelial cells | Medium | Approved |
| colon | glandular cells | Medium | Approved |
| colon | peripheral nerve/ganglion | Low | Approved |
| duodenum | glandular cells | Medium | Approved |
| endometrium 1 | cells in endometrial stroma | Low | Approved |
| endometrium 1 | glandular cells | Medium | Approved |
| endometrium 2 | glandular cells | Medium | Approved |
| epididymis | glandular cells | Medium | Approved |
| esophagus | squamous epithelial cells | Medium | Approved |
| fallopian tube | glandular cells | Medium | Approved |
| gallbladder | glandular cells | Medium | Approved |
| heart muscle | cardiomyocytes | Medium | Approved |
| hippocampus | glial cells | Medium | Approved |
| hippocampus | neuronal cells | Medium | Approved |
| kidney | cells in tubules | Medium | Approved |
| liver | cholangiocytes | Low | Approved |
| liver | hepatocytes | Medium | Approved |
| lung | alveolar cells | Low | Approved |
| lung | macrophages | Medium | Approved |
| lymph node | germinal center cells | Low | Approved |
| lymph node | non-germinal center cells | Low | Approved |
| nasopharynx | respiratory epithelial cells | Medium | Approved |
| oral mucosa | squamous epithelial cells | Medium | Approved |
| ovary | ovarian stroma cells | Low | Approved |
| pancreas | exocrine glandular cells | Medium | Approved |
| pancreas | pancreatic endocrine cells | Medium | Approved |
| parathyroid gland | glandular cells | Medium | Approved |
| placenta | decidual cells | Medium | Approved |
| placenta | trophoblastic cells | Medium | Approved |
| prostate | glandular cells | Medium | Approved |
| rectum | glandular cells | Medium | Approved |
| salivary gland | glandular cells | Medium | Approved |
| seminal vesicle | glandular cells | Medium | Approved |
| skeletal muscle | myocytes | Low | Approved |
| skin 1 | Langerhans | Medium | Approved |
| skin 1 | fibroblasts | Low | Approved |
| skin 1 | keratinocytes | Medium | Approved |
| skin 1 | melanocytes | Low | Approved |
| skin 2 | epidermal cells | Medium | Approved |
| small intestine | glandular cells | Medium | Approved |
| smooth muscle | smooth muscle cells | Medium | Approved |
| soft tissue 1 | chondrocytes | Low | Approved |
| soft tissue 1 | fibroblasts | Low | Approved |
| soft tissue 2 | fibroblasts | Low | Approved |
| spleen | cells in red pulp | Low | Approved |
| spleen | cells in white pulp | Medium | Approved |
| stomach 1 | glandular cells | Medium | Approved |
| stomach 2 | glandular cells | Medium | Approved |
| testis | Leydig cells | Medium | Approved |
| testis | cells in seminiferous ducts | Medium | Approved |
| thyroid gland | glandular cells | Medium | Approved |
| tonsil | germinal center cells | Medium | Approved |
| tonsil | non-germinal center cells | Medium | Approved |
| tonsil | squamous epithelial cells | Medium | Approved |
| urinary bladder | urothelial cells | Medium | Approved |
| vagina | squamous epithelial cells | Medium | Approved |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|---|---|---|---|---|
| nk-cell enteropathy | MONDO:0016996 | K63 | chapter11, Diseases of the digestive system | Orphanet:263665 |