MultifacetedProtDB - Bologna Biocomputing Group

Structure

PDB	Resolution (Å)	PDB name
1Z5S	3.01	Crystal structure of a complex between UBC9, SUMO-1, RANGAP1 and NUP358/RANBP2
2GRN	1.8	Crystal Structure of human RanGAP1-Ubc9
2GRO	1.7	Crystal Structure of human RanGAP1-Ubc9-N85Q
2GRP	2.05	Crystal Structure of human RanGAP1-Ubc9-Y87A
2GRQ	1.7	Crystal Structure of human RanGAP1-Ubc9-D127A
2GRR	1.3	Crystal Structure of human RanGAP1-Ubc9-D127S
2IO2	2.9	Crystal structure of human Senp2 in complex with RanGAP1-SUMO-1
2IO3	3.2	Crystal structure of human Senp2 in complex with RanGAP1-SUMO-2
2IY0	2.77	SENP1 (mutant) SUMO1 RanGAP
3UIN	2.597	Complex between human RanGAP1-SUMO2, UBC9 and the IR1 domain from RanBP2
3UIO	2.602	Complex between human RanGAP1-SUMO2, UBC9 and the IR1 domain from RanBP2 containing IR2 Motif II
3UIP	2.293	Complex between human RanGAP1-SUMO1, UBC9 and the IR1 domain from RanBP2 containing IR2 Motif II
5D2M	2.4	Complex between human SUMO2-RANGAP1, UBC9 and ZNF451

GO term

GO ontology	GO term	GO description
Biological Process	GO:0090630	activation of GTPase activity
Biological Process	GO:1904117	cellular response to vasopressin
Biological Process	GO:0046826	negative regulation of protein export from nucleus
Biological Process	GO:0051168	nuclear export
Biological Process	GO:0006913	nucleocytoplasmic transport
Biological Process	GO:0016925	protein sumoylation
Biological Process	GO:0048678	response to axon injury
Biological Process	GO:0007165	signal transduction
Molecular Function	GO:0005096	GTPase activator activity
Molecular Function	GO:0003723	RNA binding
Molecular Function	GO:0045296	cadherin binding
Molecular Function	GO:0031267	small GTPase binding
Molecular Function	GO:0031625	ubiquitin protein ligase binding
Cellular Component	GO:0106068	SUMO ligase complex
Cellular Component	GO:0016235	aggresome
Cellular Component	GO:1904115	axon cytoplasm
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:1990723	cytoplasmic periphery of the nuclear pore complex
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0030425	dendrite
Cellular Component	GO:0043231	intracellular membrane-bounded organelle
Cellular Component	GO:0000776	kinetochore
Cellular Component	GO:0072686	mitotic spindle
Cellular Component	GO:0005635	nuclear envelope
Cellular Component	GO:0031965	nuclear membrane
Cellular Component	GO:0005643	nuclear pore
Cellular Component	GO:0044614	nuclear pore cytoplasmic filaments
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0048471	perinuclear region of cytoplasm

InterPro / Pfam

InterPro	InterPro name
IPR001611	Leucine-rich repeat
IPR009109	Ran-GTPase activating protein 1, C-terminal
IPR032675	Leucine-rich repeat domain superfamily
IPR036720	Ran-GTPase activating protein 1, C-terminal domain superfamily

Pfam	Pfam name
PF07834	RanGAP1 C-terminal domain
PF13516	Leucine Rich repeat

Reactome

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-141444	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-165054	Rev-mediated nuclear export of HIV RNA	Leaf	R-HSA-1643685	Disease
R-HSA-2467813	Separation of Sister Chromatids	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-2500257	Resolution of Sister Chromatid Cohesion	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-4615885	SUMOylation of DNA replication proteins	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-5663220	RHO GTPases Activate Formins	Leaf	R-HSA-162582	Signal Transduction
R-HSA-68877	Mitotic Prometaphase	Internal node	R-HSA-1640170	Cell Cycle
R-HSA-9615933	Postmitotic nuclear pore complex (NPC) reformation	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-9648025	EML4 and NUDC in mitotic spindle formation	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-9793242	SUMOylation of nuclear envelope proteins	Leaf	R-HSA-392499	Metabolism of proteins

Subcellular location

Location	ECO term	Pubmed
Chromosome, centromere, kinetochore	ECO:0000269	PubMed:11854305
Cytoplasm	ECO:0000305	PubMed:15037602
Cytoplasm	ECO:0000305	PubMed:8146159
Cytoplasm, cytoskeleton, spindle	ECO:0000269	PubMed:11854305
Cytoplasm, cytoskeleton, spindle	ECO:0000269	PubMed:15037602
Nucleus envelope	ECO:0000269	PubMed:11854305
Nucleus envelope	ECO:0000269	PubMed:15037602
Nucleus, nucleoplasm	ECO:0000269	PubMed:8146159

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Tissue	Cell type	Expression level	Reliability
adipose tissue	adipocytes	Low	Supported
adrenal gland	glandular cells	High	Supported
appendix	glandular cells	Medium	Supported
appendix	lymphoid tissue	Medium	Supported
bone marrow	hematopoietic cells	High	Supported
breast	adipocytes	Medium	Supported
breast	glandular cells	Medium	Supported
breast	myoepithelial cells	Medium	Supported
bronchus	respiratory epithelial cells	Medium	Supported
caudate	glial cells	Low	Supported
caudate	neuronal cells	Medium	Supported
cerebellum	Purkinje cells	High	Supported
cerebellum	cells in granular layer	Low	Supported
cerebellum	cells in molecular layer	Medium	Supported
cerebral cortex	endothelial cells	Medium	Supported
cerebral cortex	glial cells	Medium	Supported
cerebral cortex	neuronal cells	High	Supported
cervix	glandular cells	High	Supported
cervix	squamous epithelial cells	Medium	Supported
colon	endothelial cells	Medium	Supported
colon	glandular cells	High	Supported
duodenum	glandular cells	Medium	Supported
endometrium 1	cells in endometrial stroma	Medium	Supported
endometrium 1	glandular cells	Medium	Supported
endometrium 2	cells in endometrial stroma	Medium	Supported
endometrium 2	glandular cells	Medium	Supported
epididymis	glandular cells	High	Supported
esophagus	squamous epithelial cells	High	Supported
fallopian tube	glandular cells	High	Supported
gallbladder	glandular cells	High	Supported
heart muscle	cardiomyocytes	Medium	Supported
hippocampus	glial cells	Low	Supported
hippocampus	neuronal cells	Medium	Supported
kidney	cells in glomeruli	High	Supported
kidney	cells in tubules	High	Supported
liver	cholangiocytes	Medium	Supported
liver	hepatocytes	Medium	Supported
lung	alveolar cells type I	High	Supported
lung	alveolar cells type II	High	Supported
lung	endothelial cells	High	Supported
lung	macrophages	High	Supported
lymph node	germinal center cells	High	Supported
lymph node	non-germinal center cells	High	Supported
nasopharynx	respiratory epithelial cells	High	Supported
oral mucosa	squamous epithelial cells	High	Supported
ovary	ovarian stroma cells	Medium	Supported
pancreas	exocrine glandular cells	High	Supported
pancreas	pancreatic endocrine cells	High	Supported
parathyroid gland	glandular cells	High	Supported
placenta	cytotrophoblasts	High	Supported
placenta	endothelial cells	High	Supported
placenta	hofbauer cells	High	Supported
placenta	syncytiotrophoblasts - cell body	High	Supported
placenta	syncytiotrophoblasts - microvilli	High	Supported
prostate	glandular cells	High	Supported
rectum	glandular cells	High	Supported
salivary gland	glandular cells	High	Supported
seminal vesicle	glandular cells	High	Supported
skeletal muscle	myocytes	Medium	Supported
skin 1	cells in basal layer	Medium	Supported
skin 1	cells in granular layer	Medium	Supported
skin 1	cells in spinous layer	High	Supported
skin 1	endothelial cells	Medium	Supported
skin 1	fibrohistiocytic cells	Medium	Supported
skin 1	langerhans cells	Medium	Supported
skin 1	lymphocytes	Medium	Supported
skin 2	cells in basal layer	High	Supported
skin 2	cells in granular layer	High	Supported
skin 2	cells in spinous layer	High	Supported
skin 2	endothelial cells	Low	Supported
skin 2	fibrohistiocytic cells	Low	Supported
skin 2	langerhans cells	High	Supported
skin 2	lymphocytes	Low	Supported
skin 2	melanocytes	Medium	Supported
small intestine	glandular cells	High	Supported
smooth muscle	smooth muscle cells	Medium	Supported
soft tissue 1	chondrocytes	Low	Supported
soft tissue 1	fibroblasts	Medium	Supported
soft tissue 1	peripheral nerve	Medium	Supported
soft tissue 2	fibroblasts	Medium	Supported
spleen	cells in red pulp	Medium	Supported
spleen	cells in white pulp	Medium	Supported
stomach 1	glandular cells	High	Supported
stomach 2	glandular cells	High	Supported
testis	Leydig cells	High	Supported
testis	peritubular cells	Low	Supported
testis	sertoli cells	High	Supported
testis	spermatogonia cells	Low	Supported
thyroid gland	glandular cells	Medium	Supported
tonsil	germinal center cells	High	Supported
tonsil	non-germinal center cells	Medium	Supported
tonsil	squamous epithelial cells	High	Supported
urinary bladder	urothelial cells	High	Supported
vagina	squamous epithelial cells	High	Supported

Summary of P46060

Gene: RANGAP1, KIAA1835, SD
Protein: Ran GTPase-activating protein 1

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of P46060

Gene: RANGAP1, KIAA1835, SD Protein: Ran GTPase-activating protein 1

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: RANGAP1, KIAA1835, SD
Protein: Ran GTPase-activating protein 1