Protein family
The protein has not catalytic activity
Protein sequence
Protein function
Catalytic activity
PDB | Resolution (Å) | PDB name |
---|---|---|
1JMQ | YAP65 (L30K mutant) WW domain in Complex with GTPPPPYTVG peptide | |
1K5R | YAP65 WW domain S24-Amino-Ethylsulfanyl-Acetic Acid mutant | |
1K9Q | YAP65 WW domain complexed to N-(n-octyl)-GPPPY-NH2 | |
1K9R | YAP65 WW domain complexed to Acetyl-PLPPY | |
2LAW | Structure of the second WW domain from human YAP in complex with a human Smad1 derived peptide | |
2LAX | Structure of first WW domain of human YAP in complex with a human Smad1 doubly-phosphorilated derived peptide. | |
2LAY | Structure of the first WW domain of human YAP in complex with a phosphorylated human Smad1 derived peptide | |
2LTV | YAP WW2 in complex with a Smad7 derived peptide | |
2LTW | YAP WW1 in complex with a Smad7 derived peptide | |
3KYS | 2.8 | Crystal structure of human YAP and TEAD complex |
3MHR | 1.15 | 14-3-3 sigma in complex with YAP pS127-peptide |
4RE1 | 2.2 | Crystal structure of human TEAD1 and disulfide-engineered YAP |
4REX | 1.6 | Crystal structure of the first WW domain of human YAP2 isoform |
5OAQ | 1.95 | TEAD4 COMPLEXED WITH YAP PEPTIDE AND MYRISTATE (COVALENTLY BOUND) |
5YDX | NMR structure of YAP1-2 WW1 domain with LATS1 PPxY motif complex | |
5YDY | NMR structure of YAP1-2 WW2 domain with LATS1 PPxY motif complex | |
6G6X | 1.13 | 14-3-3sigma in complex with a P129beta3P mutated YAP pS127 phosphopeptide |
6G8I | 1.6 | 14-3-3sigma in complex with a R124beta3R mutated YAP pS127 phosphopeptide |
6G8J | 1.47 | 14-3-3sigma in complex with a A130beta3A mutated YAP pS127 phosphopeptide |
6G8K | 1.25 | 14-3-3sigma in complex with a S131beta3S mutated YAP pS127 phosphopeptide |
6G8L | 1.37 | 14-3-3sigma in complex with a L132beta3L mutated YAP pS127 phosphopeptide |
6G8P | 1.9 | 14-3-3sigma in complex with a P129beta3P and L132beta3L mutated YAP pS127 phosphopeptide |
6G8Q | 1.85 | 14-3-3sigma in complex with a A130beta3A and Q133beta3Q mutated YAP pS127 phosphopeptide |
6GE3 | 1.85 | X-ray structure of TEAD4 (wildtype) complexed with YAP (wildtype): The role of residual flexibility and water molecules in the adaptation of a bound intrinsically disordered protein to mutations at a binding interface |
6GE4 | 1.97 | TEAD4 (216-434);E263A COMPLEXED WITH YAP PEPTIDE (60-100) AND MYRISTOATE (COVALENTLY BOUND) AT 1.97A (P41212 CRYSTAL FORM); MYRISTOYLATION WAS DONE BY ADDING MYR-COA |
6GE5 | 2.05 | TEAD4 (216-434);Y429F COMPLEXED WITH YAP PEPTIDE (60-100) AND MYRISTOATE (COVALENTLY BOUND) AT 2.05A (P41212 CRYSTAL FORM); MYRISTOYLATION WAS DONE BY ADDING MYR-COA |
6GE6 | 1.8 | X-ray structure of TEAD4(E263A+Y429F mutant) complexed with YAP(wildtype): The role of residual flexibility and water molecules in the adaptation of a bound intrinsically disordered protein to mutations at a binding interface |
6GEC | 1.7 | TEAD4 (216-434) COMPLEXED WITH YAP PEPTIDE (60-100);S94A AND MYRISTOATE (COVALENTLY BOUND) AT 1.70A (P41212 CRYSTAL FORM); MYRISTOYLATION WAS DONE BY ADDING MYR-COA |
6GEE | 1.96 | TEAD4 (216-434);E263A COMPLEXED WITH YAP PEPTIDE (60-100); S94A AND MYRISTOATE (COVALENTLY BOUND) AT 1.96A (P41212 CRYSTAL FORM); MYRISTOYLATION WAS DONE BY ADDING MYR-COA |
6GEG | 2.23 | TEAD4 (216-434);Y429F COMPLEXED WITH YAP PEPTIDE (60-100); S94A AND MYRISTOATE (COVALENTLY BOUND) AT 2.23A (P41212 CRYSTAL FORM); MYRISTOYLATION WAS DONE BY ADDING MYR-COA |
6GEI | 1.65 | TEAD4 (216-434);E263A+Y429F COMPLEXED WITH YAP PEPTIDE (60- 100);S94A AND MYRISTOATE (COVALENTLY BOUND TO LYS344, NOT CYS367!) AT 1.65A (P41212 CRYSTAL FORM); MYRISTOYLATION WAS DONE BY ADDING MYR-COA |
6GEK | 2.28 | TEAD4 (216-434);Y429F COMPLEXED WITH YAP PEPTIDE (60-100) AND MYRISTOATE (COVALENTLY BOUND) AT 2.28A (P212121 CRYSTAL FORM); MYRISTOYLATION WAS DONE BY ADDING MYR-COA |
6HIK | 1.65 | X-ray structure of TEAD4(Y429H) mutant) complexed with YAP (wildtype): Molecular and structural characterization of a TEAD mutation at the origin of Sveinsson's chorioretinal atrophy |
6HIL | 2.3 | X-ray structure of TEAD1(Y421H mutant) complexed with YAP(wildtype): Molecular and structural characterization of a TEAD mutation at the origin of Sveinsson's chorioretinal atrophy |
6Q2X | 2.1 | TEAD4 (216-434) COMPLEXED WITH YAP PEPTIDE (60-100) AND MYRISTOATE (COVALENTLY BOUND) AT 2.1A (P41212 CRYSTAL FORM) |
7O07 | 1.2 | 14-3-3sigma covalently bound to peptide (chloroacetamide-Cys interaction) |
8A8Q | 1.465 | Crystal structure of Protein Scalloped in complex with YAP peptide |
8A8R | 1.696 | Crystal structure of TEAD4 in complex with YAP peptide |
GO ontology | GO term | GO description |
---|---|---|
Biological Process | GO:0006974 | DNA damage response |
Biological Process | GO:0060449 | bud elongation involved in lung branching |
Biological Process | GO:0060070 | canonical Wnt signaling pathway |
Biological Process | GO:0061026 | cardiac muscle tissue regeneration |
Biological Process | GO:0000902 | cell morphogenesis |
Biological Process | GO:0008283 | cell population proliferation |
Biological Process | GO:0071480 | cellular response to gamma radiation |
Biological Process | GO:0071300 | cellular response to retinoic acid |
Biological Process | GO:0060242 | contact inhibition |
Biological Process | GO:0003143 | embryonic heart tube morphogenesis |
Biological Process | GO:1903703 | enterocyte differentiation |
Biological Process | GO:0050673 | epithelial cell proliferation |
Biological Process | GO:0097191 | extrinsic apoptotic signaling pathway |
Biological Process | GO:0002067 | glandular epithelial cell differentiation |
Biological Process | GO:0003015 | heart process |
Biological Process | GO:0035329 | hippo signaling |
Biological Process | GO:0070102 | interleukin-6-mediated signaling pathway |
Biological Process | GO:0060576 | intestinal epithelial cell development |
Biological Process | GO:0030216 | keratinocyte differentiation |
Biological Process | GO:0048368 | lateral mesoderm development |
Biological Process | GO:0060487 | lung epithelial cell differentiation |
Biological Process | GO:1902018 | negative regulation of cilium assembly |
Biological Process | GO:1904036 | negative regulation of epithelial cell apoptotic process |
Biological Process | GO:0030857 | negative regulation of epithelial cell differentiation |
Biological Process | GO:2001237 | negative regulation of extrinsic apoptotic signaling pathway |
Biological Process | GO:0045599 | negative regulation of fat cell differentiation |
Biological Process | GO:0010629 | negative regulation of gene expression |
Biological Process | GO:2000737 | negative regulation of stem cell differentiation |
Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
Biological Process | GO:0030903 | notochord development |
Biological Process | GO:0035265 | organ growth |
Biological Process | GO:0048339 | paraxial mesoderm development |
Biological Process | GO:0030859 | polarized epithelial cell differentiation |
Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
Biological Process | GO:0045747 | positive regulation of Notch signaling pathway |
Biological Process | GO:0090263 | positive regulation of canonical Wnt signaling pathway |
Biological Process | GO:0060045 | positive regulation of cardiac muscle cell proliferation |
Biological Process | GO:0030307 | positive regulation of cell growth |
Biological Process | GO:0050679 | positive regulation of epithelial cell proliferation |
Biological Process | GO:0010628 | positive regulation of gene expression |
Biological Process | GO:0033148 | positive regulation of intracellular estrogen receptor signaling pathway |
Biological Process | GO:0045669 | positive regulation of osteoblast differentiation |
Biological Process | GO:1900182 | positive regulation of protein localization to nucleus |
Biological Process | GO:1902459 | positive regulation of stem cell population maintenance |
Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
Biological Process | GO:0050847 | progesterone receptor signaling pathway |
Biological Process | GO:0065003 | protein-containing complex assembly |
Biological Process | GO:0010837 | regulation of keratinocyte proliferation |
Biological Process | GO:0072307 | regulation of metanephric nephron tubule epithelial cell differentiation |
Biological Process | GO:0050767 | regulation of neurogenesis |
Biological Process | GO:0072091 | regulation of stem cell proliferation |
Biological Process | GO:0032570 | response to progesterone |
Biological Process | GO:0035019 | somatic stem cell population maintenance |
Biological Process | GO:0001894 | tissue homeostasis |
Biological Process | GO:0001829 | trophectodermal cell differentiation |
Biological Process | GO:0001570 | vasculogenesis |
Biological Process | GO:0042060 | wound healing |
Molecular Function | GO:0140297 | DNA-binding transcription factor binding |
Molecular Function | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
Molecular Function | GO:0003682 | chromatin binding |
Molecular Function | GO:0140678 | molecular function inhibitor activity |
Molecular Function | GO:0070064 | proline-rich region binding |
Molecular Function | GO:0000976 | transcription cis-regulatory region binding |
Molecular Function | GO:0003713 | transcription coactivator activity |
Molecular Function | GO:0003714 | transcription corepressor activity |
Cellular Component | GO:0140552 | TEAD-YAP complex |
Cellular Component | GO:0070161 | anchoring junction |
Cellular Component | GO:0030054 | cell junction |
Cellular Component | GO:0005737 | cytoplasm |
Cellular Component | GO:0005829 | cytosol |
Cellular Component | GO:0001674 | female germ cell nucleus |
Cellular Component | GO:0016020 | membrane |
Cellular Component | GO:0005654 | nucleoplasm |
Cellular Component | GO:0005634 | nucleus |
Reactome | Reactome Name | Node type | Reactome Root | Reactome Root Name |
---|---|---|---|---|
R-HSA-1251985 | Nuclear signaling by ERBB4 | Leaf | R-HSA-162582 | Signal Transduction |
R-HSA-2028269 | Signaling by Hippo | Leaf | R-HSA-162582 | Signal Transduction |
R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | Leaf | R-HSA-74160 | Gene expression (Transcription) |
R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | Leaf | R-HSA-74160 | Gene expression (Transcription) |
R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | Leaf | R-HSA-74160 | Gene expression (Transcription) |
R-HSA-8951671 | RUNX3 regulates YAP1-mediated transcription | Leaf | R-HSA-74160 | Gene expression (Transcription) |
R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | Leaf | R-HSA-1266738 | Developmental Biology |
R-HSA-9796292 | Formation of axial mesoderm | Leaf | R-HSA-1266738 | Developmental Biology |
Location | ECO term | Pubmed |
---|---|---|
Cell junction | ECO:0000250 | |
Cytoplasm | ECO:0000269 | PubMed:18158288 |
Cytoplasm | ECO:0000269 | PubMed:18280240 |
Cytoplasm | ECO:0000269 | PubMed:20048001 |
Cytoplasm | ECO:0000269 | PubMed:22525271 |
Cytoplasm | ECO:0000269 | PubMed:25849865 |
Cytoplasm | ECO:0000269 | PubMed:29400695 |
Nucleus | ECO:0000269 | PubMed:17974916 |
Nucleus | ECO:0000269 | PubMed:18158288 |
Nucleus | ECO:0000269 | PubMed:18280240 |
Nucleus | ECO:0000269 | PubMed:20048001 |
Nucleus | ECO:0000269 | PubMed:21145499 |
Nucleus | ECO:0000269 | PubMed:22525271 |
Nucleus | ECO:0000269 | PubMed:25849865 |
Nucleus | ECO:0000269 | PubMed:28169360 |
Nucleus | ECO:0000269 | PubMed:29400695 |
Nucleus | ECO:0000269 | PubMed:30447097 |
HPO ID | HPO name |
---|---|
HP:0000006 | Autosomal dominant inheritance |
HP:0000175 | Cleft palate |
HP:0000204 | Cleft upper lip |
HP:0000365 | Hearing impairment |
HP:0000407 | Sensorineural hearing impairment |
HP:0000486 | Strabismus |
HP:0000501 | Glaucoma |
HP:0000505 | Visual impairment |
HP:0000508 | Ptosis |
HP:0000518 | Cataract |
HP:0000541 | Retinal detachment |
HP:0000567 | Chorioretinal coloboma |
HP:0000568 | Microphthalmia |
HP:0000612 | Iris coloboma |
HP:0000627 | Posterior embryotoxon |
HP:0000639 | Nystagmus |
HP:0000648 | Optic atrophy |
HP:0000790 | Hematuria |
HP:0001249 | Intellectual disability |
HP:0002744 | Bilateral cleft lip and palate |
HP:0003577 | Congenital onset |
HP:0007957 | Corneal opacity |
Disease name | MONDO ID | ICD10 | ICD10 chapter | OMIM | Orphanet |
---|---|---|---|---|---|
uveal coloboma-cleft lip and palate-intellectual disability | MONDO:0007355 | Q12 | chapter17, Congenital malformations, deformations and chromosomal abnormalities | OMIM:120433 | Orphanet:1473 |
plasma cell myeloma | MONDO:0009693 | C90 | chapter2, Neoplasms | OMIM:254500 | Orphanet:29073 |
plasma cell myeloma | MONDO:0009693 | C90 | chapter2, Neoplasms | OMIM:254500 | Orphanet:314701 |
plasma cell myeloma | MONDO:0009693 | C90 | chapter2, Neoplasms | OMIM:254500 | Orphanet:85443 |
al amyloidosis | MONDO:0019438 | E85 | chapter4, Endocrine, nutritional and metabolic diseases | Orphanet:85443 |