Protein family
Protein sequence
Protein function
Publications
Catalytic activity
EC number
EC number description
3.1.1.4
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases;
phospholipase A2
3.1.1.5
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases;
lysophospholipase
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0019369 | arachidonic acid metabolic process |
| Biological Process | GO:0050482 | arachidonic acid secretion |
| Biological Process | GO:0071236 | cellular response to antibiotic |
| Biological Process | GO:0051649 | establishment of localization in cell |
| Biological Process | GO:0006071 | glycerol metabolic process |
| Biological Process | GO:0046475 | glycerophospholipid catabolic process |
| Biological Process | GO:0006690 | icosanoid metabolic process |
| Biological Process | GO:0019370 | leukotriene biosynthetic process |
| Biological Process | GO:0006640 | monoacylglycerol biosynthetic process |
| Biological Process | GO:0036151 | phosphatidylcholine acyl-chain remodeling |
| Biological Process | GO:0034638 | phosphatidylcholine catabolic process |
| Biological Process | GO:0034478 | phosphatidylglycerol catabolic process |
| Biological Process | GO:0006663 | platelet activating factor biosynthetic process |
| Biological Process | GO:0002827 | positive regulation of T-helper 1 type immune response |
| Biological Process | GO:0043032 | positive regulation of macrophage activation |
| Biological Process | GO:0010572 | positive regulation of platelet activation |
| Biological Process | GO:0032308 | positive regulation of prostaglandin secretion |
| Biological Process | GO:0001516 | prostaglandin biosynthetic process |
| Biological Process | GO:0042127 | regulation of cell population proliferation |
| Molecular Function | GO:0008374 | O-acyltransferase activity |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0047498 | calcium-dependent phospholipase A2 activity |
| Molecular Function | GO:0005544 | calcium-dependent phospholipid binding |
| Molecular Function | GO:0047499 | calcium-independent phospholipase A2 activity |
| Molecular Function | GO:1902387 | ceramide 1-phosphate binding |
| Molecular Function | GO:0004622 | lysophospholipase activity |
| Molecular Function | GO:0102545 | phosphatidyl phospholipase B activity |
| Molecular Function | GO:0032266 | phosphatidylinositol-3-phosphate binding |
| Molecular Function | GO:0070273 | phosphatidylinositol-4-phosphate binding |
| Molecular Function | GO:0010314 | phosphatidylinositol-5-phosphate binding |
| Molecular Function | GO:0004623 | phospholipase A2 activity |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0000139 | Golgi membrane |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0043231 | intracellular membrane-bounded organelle |
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0005635 | nuclear envelope |
| Cellular Component | GO:0005634 | nucleus |
| InterPro
|
InterPro name |
|---|---|
| IPR000008 | C2 domain |
| IPR002642 | Lysophospholipase, catalytic domain |
| IPR016035 | Acyl transferase/acyl hydrolase/lysophospholipase |
| IPR035892 | C2 domain superfamily |
| IPR041847 | Cytosolic phospholipase A2, C2 domain |
| Pfam
|
Pfam name |
|---|---|
| PF00168 | C2 domain |
| PF01735 | Lysophospholipase catalytic domain |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-111995 | phospho-PLA2 pathway | Leaf | R-HSA-162582 | Signal Transduction |
| R-HSA-1482788 | Acyl chain remodelling of PC | Leaf | R-HSA-1430728 | Metabolism |
| R-HSA-1482798 | Acyl chain remodeling of CL | Leaf | R-HSA-1430728 | Metabolism |
| R-HSA-1482801 | Acyl chain remodelling of PS | Leaf | R-HSA-1430728 | Metabolism |
| R-HSA-1482839 | Acyl chain remodelling of PE | Leaf | R-HSA-1430728 | Metabolism |
| R-HSA-1482922 | Acyl chain remodelling of PI | Leaf | R-HSA-1430728 | Metabolism |
| R-HSA-1482925 | Acyl chain remodelling of PG | Leaf | R-HSA-1430728 | Metabolism |
| R-HSA-1483115 | Hydrolysis of LPC | Leaf | R-HSA-1430728 | Metabolism |
| R-HSA-1483166 | Synthesis of PA | Leaf | R-HSA-1430728 | Metabolism |
| R-HSA-2142753 | Arachidonic acid metabolism | Internal node | R-HSA-1430728 | Metabolism |
| R-HSA-418592 | ADP signalling through P2Y purinoceptor 1 | Leaf | R-HSA-109582 | Hemostasis |
| R-HSA-432142 | Platelet sensitization by LDL | Leaf | R-HSA-109582 | Hemostasis |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | Leaf | R-HSA-5653656 | Vesicle-mediated transport |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Cytoplasm | ECO:0000269 | PubMed:11375391 |
| Golgi apparatus membrane | ECO:0000269 | PubMed:11375391 |
| Nucleus envelope |
| HPO ID
|
HPO name |
|---|---|
| HP:0000007 | Autosomal recessive inheritance |
| HP:0001891 | Iron deficiency anemia |
| HP:0002588 | Duodenal ulcer |
| HP:0002592 | Gastric ulcer |
| HP:0003540 | Impaired platelet aggregation |
| HP:0004791 | Esophageal ulceration |
| HP:0030361 | Abnormal circulating eicosanoid concentration |
| HP:0032244 | Decreased serum thromboxane B2 |
| HP:0032575 | Decreased circulating 12-HETE |
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adipose tissue | adipocytes | Medium | Approved |
| adrenal gland | glandular cells | Medium | Approved |
| appendix | glandular cells | Low | Approved |
| appendix | lymphoid tissue | Low | Approved |
| bone marrow | hematopoietic cells | Low | Approved |
| breast | glandular cells | Medium | Approved |
| breast | myoepithelial cells | Medium | Approved |
| bronchus | respiratory epithelial cells | Medium | Approved |
| caudate | neuronal cells | Low | Approved |
| cerebellum | Purkinje cells | Medium | Approved |
| cerebellum | cells in molecular layer | Low | Approved |
| cerebral cortex | glial cells | Low | Approved |
| cerebral cortex | neuronal cells | Medium | Approved |
| cerebral cortex | neuropil | Low | Approved |
| cervix | glandular cells | Low | Approved |
| cervix | squamous epithelial cells | Low | Approved |
| colon | endothelial cells | Low | Approved |
| colon | glandular cells | Medium | Approved |
| colon | peripheral nerve/ganglion | Medium | Approved |
| duodenum | glandular cells | Medium | Approved |
| endometrium 1 | glandular cells | Medium | Approved |
| endometrium 2 | glandular cells | Medium | Approved |
| epididymis | glandular cells | Low | Approved |
| esophagus | squamous epithelial cells | Low | Approved |
| fallopian tube | glandular cells | Medium | Approved |
| gallbladder | glandular cells | Medium | Approved |
| heart muscle | cardiomyocytes | Low | Approved |
| hippocampus | neuronal cells | Medium | Approved |
| kidney | cells in tubules | Medium | Approved |
| liver | hepatocytes | Medium | Approved |
| lung | macrophages | Medium | Approved |
| lymph node | germinal center cells | Low | Approved |
| lymph node | non-germinal center cells | Low | Approved |
| nasopharynx | respiratory epithelial cells | Medium | Approved |
| oral mucosa | squamous epithelial cells | Low | Approved |
| pancreas | exocrine glandular cells | Low | Approved |
| pancreas | pancreatic endocrine cells | Low | Approved |
| parathyroid gland | glandular cells | High | Approved |
| placenta | trophoblastic cells | Medium | Approved |
| prostate | glandular cells | Low | Approved |
| seminal vesicle | glandular cells | High | Approved |
| skeletal muscle | myocytes | Medium | Approved |
| skin 1 | Langerhans | Medium | Approved |
| skin 1 | fibroblasts | Low | Approved |
| skin 1 | keratinocytes | Medium | Approved |
| skin 2 | epidermal cells | Low | Approved |
| small intestine | glandular cells | Low | Approved |
| smooth muscle | smooth muscle cells | Low | Approved |
| soft tissue 1 | fibroblasts | Low | Approved |
| soft tissue 2 | fibroblasts | Low | Approved |
| soft tissue 2 | peripheral nerve | Low | Approved |
| spleen | cells in red pulp | Low | Approved |
| stomach 1 | glandular cells | Medium | Approved |
| stomach 2 | glandular cells | Medium | Approved |
| testis | Leydig cells | Medium | Approved |
| testis | elongated or late spermatids | Medium | Approved |
| thyroid gland | glandular cells | Low | Approved |
| tonsil | squamous epithelial cells | Low | Approved |
| urinary bladder | urothelial cells | Medium | Approved |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|---|---|---|---|---|
| cryptogenic multifocal ulcerous stenosing enteritis | MONDO:0018765 | K63 | chapter11, Diseases of the digestive system | Orphanet:468635 | |
| cytosolic phospholipase-a2 alpha deficiency associated bleeding disorder | MONDO:0018794 | K63 | chapter11, Diseases of the digestive system | OMIM:618372 | Orphanet:477787 |