MultifacetedProtDB - Bologna Biocomputing Group

EC number	EC number description
1.17.1.4	Oxidoreductases; Acting on CH or CH2 groups; With NAD+ or NADP+ as acceptor; xanthine dehydrogenase
1.17.3.2	Oxidoreductases; Acting on CH or CH2 groups; With oxygen as acceptor; xanthine oxidase

Structure

PDB	Resolution (Å)	PDB name
2CKJ	3.59	Human milk xanthine oxidoreductase
2E1Q	2.6	Crystal Structure of Human Xanthine Oxidoreductase mutant, Glu803Val

GO term

GO ontology	GO term	GO description
Biological Process	GO:0006196	AMP catabolic process
Biological Process	GO:0046038	GMP catabolic process
Biological Process	GO:0006204	IMP catabolic process
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
Biological Process	GO:0006154	adenosine catabolic process
Biological Process	GO:0000255	allantoin metabolic process
Biological Process	GO:0043605	amide catabolic process
Biological Process	GO:0046059	dAMP catabolic process
Biological Process	GO:0046055	dGMP catabolic process
Biological Process	GO:0006157	deoxyadenosine catabolic process
Biological Process	GO:0006161	deoxyguanosine catabolic process
Biological Process	GO:0006149	deoxyinosine catabolic process
Biological Process	GO:0006147	guanine catabolic process
Biological Process	GO:0009114	hypoxanthine catabolic process
Biological Process	GO:0006148	inosine catabolic process
Biological Process	GO:0016226	iron-sulfur cluster assembly
Biological Process	GO:0007595	lactation
Biological Process	GO:0045602	negative regulation of endothelial cell differentiation
Biological Process	GO:0001937	negative regulation of endothelial cell proliferation
Biological Process	GO:0010629	negative regulation of gene expression
Biological Process	GO:0051898	negative regulation of protein kinase B signaling
Biological Process	GO:0001933	negative regulation of protein phosphorylation
Biological Process	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway
Biological Process	GO:2001213	negative regulation of vasculogenesis
Biological Process	GO:1900745	positive regulation of p38MAPK cascade
Biological Process	GO:2000379	positive regulation of reactive oxygen species metabolic process
Biological Process	GO:0009115	xanthine catabolic process
Molecular Function	GO:0051537	2 iron, 2 sulfur cluster binding
Molecular Function	GO:0071949	FAD binding
Molecular Function	GO:0050660	flavin adenine dinucleotide binding
Molecular Function	GO:0070674	hypoxanthine dehydrogenase activity
Molecular Function	GO:0070675	hypoxanthine oxidase activity
Molecular Function	GO:0005506	iron ion binding
Molecular Function	GO:0043546	molybdopterin cofactor binding
Molecular Function	GO:0042803	protein homodimerization activity
Molecular Function	GO:0004854	xanthine dehydrogenase activity
Molecular Function	GO:0004855	xanthine oxidase activity
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005615	extracellular space
Cellular Component	GO:0005777	peroxisome
Cellular Component	GO:0016529	sarcoplasmic reticulum

InterPro / Pfam

InterPro	InterPro name
IPR000674	Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead
IPR001041	2Fe-2S ferredoxin-type iron-sulfur binding domain
IPR002346	Molybdopterin dehydrogenase, FAD-binding
IPR002888	[2Fe-2S]-binding
IPR005107	CO dehydrogenase flavoprotein, C-terminal
IPR006058	2Fe-2S ferredoxin, iron-sulphur binding site
IPR008274	Aldehyde oxidase/xanthine dehydrogenase, first molybdopterin binding domain
IPR012675	Beta-grasp domain superfamily
IPR014307	Xanthine dehydrogenase, small subunit
IPR016166	FAD-binding domain, PCMH-type
IPR016167	FAD-binding, type PCMH, subdomain 1
IPR016169	FAD-binding, type PCMH, subdomain 2
IPR016208	Aldehyde oxidase/xanthine dehydrogenase
IPR022407	Oxidoreductase, molybdopterin binding site
IPR036010	2Fe-2S ferredoxin-like superfamily
IPR036318	FAD-binding, type PCMH-like superfamily
IPR036683	CO dehydrogenase flavoprotein, C-terminal domain superfamily
IPR036856	Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead superfamily
IPR036884	[2Fe-2S]-binding domain superfamily
IPR037165	Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain superfamily
IPR046867	Aldehyde oxidase/xanthine dehydrogenase, second molybdopterin binding domain

Pfam	Pfam name
PF00111	2Fe-2S iron-sulfur cluster binding domain
PF00941	FAD binding domain in molybdopterin dehydrogenase
PF01315	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF01799	[2Fe-2S] binding domain
PF02738	Molybdopterin cofactor-binding domain
PF03450	CO dehydrogenase flavoprotein C-terminal domain
PF20256	Molybdopterin cofactor-binding domain

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-74259	Purine catabolism	Internal node	R-HSA-1430728	Metabolism
R-HSA-8851680	Butyrophilin (BTN) family interactions	Leaf	R-HSA-168256	Immune System
R-HSA-9748787	Azathioprine ADME	Leaf	R-HSA-9748784	Drug ADME

Location	ECO term	Pubmed
Cytoplasm	ECO:0000250
Peroxisome	ECO:0000250
Secreted

HPO ID	HPO name
HP:0000007	Autosomal recessive inheritance
HP:0000126	Hydronephrosis
HP:0000804	Xanthine nephrolithiasis
HP:0001939	Abnormality of metabolism/homeostasis
HP:0003198	Myopathy
HP:0003534	Reduced xanthine dehydrogenase level
HP:0010933	Hyperxanthinemia
HP:0010934	Xanthinuria
HP:0012330	Pyelonephritis

Tissue	Cell type	Expression level	Reliability
duodenum	enterocytes	Low	Supported
duodenum	enterocytes - Microvilli	Low	Supported
kidney	cells in tubules	Low	Supported
lactating breast	lactating glandular cells	Medium	Supported
small intestine	enterocytes	Low	Supported
small intestine	enterocytes - Microvilli	Low	Supported

Summary of P47989

Gene: XDH, XDHA
Protein: Xanthine dehydrogenase/oxidase

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of P47989

Gene: XDH, XDHA Protein: Xanthine dehydrogenase/oxidase

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: XDH, XDHA
Protein: Xanthine dehydrogenase/oxidase