MultifacetedProtDB - Bologna Biocomputing Group

Structure

PDB	Resolution (Å)	PDB name
1J8I		Solution Structure of Human Lymphotactin
1J9O		SOLUTION STRUCTURE OF HUMAN LYMPHOTACTIN
2HDM		Solution structure of V21C/V59C Lymphotactin/XCL1
2JP1		Solution structure of the alternative conformation of XCL1/Lymphotactin
2N54		Solution structure of a disulfide stabilized XCL1 dimer
2NYZ	2.6	Viral Chemokine Binding Protein M3 From Murine Gammaherpesvirus68 In Complex With The C- Chemokine XCL1

GO term

GO ontology	GO term	GO description
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway
Biological Process	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide
Biological Process	GO:0007267	cell-cell signaling
Biological Process	GO:0071347	cellular response to interleukin-1
Biological Process	GO:0071353	cellular response to interleukin-4
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus
Biological Process	GO:0071356	cellular response to tumor necrosis factor
Biological Process	GO:0071346	cellular response to type II interferon
Biological Process	GO:0070098	chemokine-mediated signaling pathway
Biological Process	GO:0048245	eosinophil chemotaxis
Biological Process	GO:0006954	inflammatory response
Biological Process	GO:0031640	killing of cells of another organism
Biological Process	GO:0048247	lymphocyte chemotaxis
Biological Process	GO:0035782	mature natural killer cell chemotaxis
Biological Process	GO:0002548	monocyte chemotaxis
Biological Process	GO:2000562	negative regulation of CD4-positive, alpha-beta T cell proliferation
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity
Biological Process	GO:0045892	negative regulation of DNA-templated transcription
Biological Process	GO:0002725	negative regulation of T cell cytokine production
Biological Process	GO:2000518	negative regulation of T-helper 1 cell activation
Biological Process	GO:0002826	negative regulation of T-helper 1 type immune response
Biological Process	GO:0032703	negative regulation of interleukin-2 production
Biological Process	GO:0032689	negative regulation of type II interferon production
Biological Process	GO:0030593	neutrophil chemotaxis
Biological Process	GO:2000538	positive regulation of B cell chemotaxis
Biological Process	GO:2000563	positive regulation of CD4-positive, alpha-beta T cell proliferation
Biological Process	GO:2000566	positive regulation of CD8-positive, alpha-beta T cell proliferation
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade
Biological Process	GO:0043547	positive regulation of GTPase activity
Biological Process	GO:0010820	positive regulation of T cell chemotaxis
Biological Process	GO:0002726	positive regulation of T cell cytokine production
Biological Process	GO:0001916	positive regulation of T cell mediated cytotoxicity
Biological Process	GO:2000556	positive regulation of T-helper 1 cell cytokine production
Biological Process	GO:2000553	positive regulation of T-helper 2 cell cytokine production
Biological Process	GO:2000513	positive regulation of granzyme A production
Biological Process	GO:0071663	positive regulation of granzyme B production
Biological Process	GO:2000558	positive regulation of immunoglobulin production in mucosal tissue
Biological Process	GO:0032733	positive regulation of interleukin-10 production
Biological Process	GO:0002690	positive regulation of leukocyte chemotaxis
Biological Process	GO:2000503	positive regulation of natural killer cell chemotaxis
Biological Process	GO:0090023	positive regulation of neutrophil chemotaxis
Biological Process	GO:0051281	positive regulation of release of sequestered calcium ion into cytosol
Biological Process	GO:2000412	positive regulation of thymocyte migration
Biological Process	GO:0071636	positive regulation of transforming growth factor beta production
Biological Process	GO:0050727	regulation of inflammatory response
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol
Biological Process	GO:0009615	response to virus
Biological Process	GO:0007165	signal transduction
Molecular Function	GO:0048020	CCR chemokine receptor binding
Molecular Function	GO:0008009	chemokine activity
Molecular Function	GO:0042379	chemokine receptor binding
Molecular Function	GO:0042803	protein homodimerization activity
Cellular Component	GO:0005576	extracellular region
Cellular Component	GO:0005615	extracellular space

InterPro	InterPro name
IPR001811	Chemokine interleukin-8-like domain
IPR008105	C chemokine
IPR036048	Chemokine interleukin-8-like superfamily
IPR039809	Chemokine beta/gamma/delta

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-380108	Chemokine receptors bind chemokines	Leaf	R-HSA-162582	Signal Transduction
R-HSA-416476	G alpha (q) signalling events	Internal node	R-HSA-162582	Signal Transduction

Tissue	Cell type	Expression level	Reliability
appendix	glandular cells	Low	Approved
gallbladder	glandular cells	Medium	Approved
kidney	cells in tubules	Low	Approved
lung	macrophages	Medium	Approved
lymph node	non-germinal center cells	Low	Approved
nasopharynx	respiratory epithelial cells	Low	Approved
tonsil	non-germinal center cells	Medium	Approved

Summary of P47992

Gene: XCL1, LTN, SCYC1
Protein: Lymphotactin

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of P47992

Gene: XCL1, LTN, SCYC1 Protein: Lymphotactin

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: XCL1, LTN, SCYC1
Protein: Lymphotactin