Protein family
The protein has not catalytic activity
Protein sequence
Protein function
Catalytic activity
PDB | Resolution (Å) | PDB name |
---|---|---|
1OW6 | 2.35 | Paxillin LD4 motif bound to the Focal Adhesion Targeting (FAT) domain of the Focal Adhesion Kinase |
1OW7 | 2.6 | Paxillin LD4 motif bound to the Focal Adhesion Targeting (FAT) domain of the Focal Adhesion Kinase |
1OW8 | 2.85 | Paxillin LD2 motif bound to the Focal Adhesion Targeting (FAT) domain of the Focal Adhesion Kinase |
2K2R | The NMR structure of alpha-parvin CH2/paxillin LD1 complex | |
2O9V | 1.63 | The second SH3 domain from Ponsin in complex with the paxillin proline rich region |
2VZD | 2.1 | Crystal structure of the C-terminal calponin homology domain of alpha parvin in complex with paxillin LD1 motif |
2VZG | 1.8 | Crystal structure of the C-terminal calponin homology domain of alpha- parvin in complex with paxillin LD2 motif |
2VZI | 2.2 | Crystal structure of the C-terminal calponin homology domain of alpha- parvin in complex with paxillin LD4 motif |
3GM1 | 2.95 | Crystal Structure of the Focal Adhesion Targeting (FAT) Domain of Pyk2 in Complex with Paxillin LD4 Motif-Derived Peptides |
3PY7 | 2.288 | Crystal structure of full-length Bovine Papillomavirus oncoprotein E6 in complex with LD1 motif of paxillin at 2.3A resolution |
3RQE | 2.8 | Cerebral cavernous malformation 3 (CCM3) in complex with paxillin LD1 |
3RQF | 2.7 | Cerebral cavernous malformation 3 (CCM3) in complex with paxillin LD2 |
3RQG | 2.5 | Cerebral cavernous malformation 3 (CCM3) in complex with paxillin LD4 |
3U3F | 3.101 | Structural basis for the interaction of Pyk2 PAT domain with paxillin LD motifs |
4EDN | 2.9 | Crystal structure of beta-parvin CH2 domain in complex with paxillin LD1 motif |
4R32 | 3.505 | Crystal Structure Analysis of Pyk2 and Paxillin LD motifs |
4XGZ | 2.5 | Crystal structure of human paxillin LD2 motif in complex with Fab fragment |
4XH2 | 2.0 | Crystal structure of human paxillin LD4 motif in complex with Fab fragment |
5UWH | 2.26 | Crystal Structure of Paxillin NES Peptide in complex with CRM1-Ran-RanBP1 |
6IUI | 2.6 | Crystal structure of GIT1 PBD domain in complex with Paxillin LD4 motif |
6PW8 | 1.95 | Hydrocarbon-Stapled Paxillin Peptide Bound to the Focal Adhesion Targeting (FAT) Domain of the Focal Adhesion Kinase (FAK) |
6U4M | Solution structure of paxillin LIM4 | |
6U4N | Solution structure of paxillin LIM4 in complex with kindlin-2 F0 | |
7QB0 | Solution structure of paxillin LIM2/3 |
GO ontology | GO term | GO description |
---|---|---|
Biological Process | GO:0007155 | cell adhesion |
Biological Process | GO:0016477 | cell migration |
Biological Process | GO:0034614 | cellular response to reactive oxygen species |
Biological Process | GO:0043542 | endothelial cell migration |
Biological Process | GO:0060396 | growth hormone receptor signaling pathway |
Biological Process | GO:0051496 | positive regulation of stress fiber assembly |
Biological Process | GO:0007172 | signal complex assembly |
Biological Process | GO:0007165 | signal transduction |
Biological Process | GO:0034446 | substrate adhesion-dependent cell spreading |
Biological Process | GO:0007179 | transforming growth factor beta receptor signaling pathway |
Molecular Function | GO:0008013 | beta-catenin binding |
Molecular Function | GO:0046872 | metal ion binding |
Molecular Function | GO:0038191 | neuropilin binding |
Molecular Function | GO:0019903 | protein phosphatase binding |
Molecular Function | GO:0017166 | vinculin binding |
Cellular Component | GO:0005938 | cell cortex |
Cellular Component | GO:0005911 | cell-cell junction |
Cellular Component | GO:0005829 | cytosol |
Cellular Component | GO:0005925 | focal adhesion |
Cellular Component | GO:0030027 | lamellipodium |
Cellular Component | GO:0005875 | microtubule associated complex |
Cellular Component | GO:0005886 | plasma membrane |
Cellular Component | GO:0001725 | stress fiber |
Reactome | Reactome Name | Node type | Reactome Root | Reactome Root Name |
---|---|---|---|---|
R-HSA-180292 | GAB1 signalosome | Leaf | R-HSA-162582 | Signal Transduction |
R-HSA-4420097 | VEGFA-VEGFR2 Pathway | Internal node | R-HSA-162582 | Signal Transduction |
R-HSA-445355 | Smooth Muscle Contraction | Leaf | R-HSA-397014 | Muscle contraction |
R-HSA-446343 | Localization of the PINCH-ILK-PARVIN complex to focal adhesions | Leaf | R-HSA-1500931 | Cell-Cell communication |
R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex components | Leaf | R-HSA-1500931 | Cell-Cell communication |
R-HSA-8849471 | PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases | Leaf | R-HSA-162582 | Signal Transduction |
Location | ECO term | Pubmed |
---|---|---|
Cell junction, focal adhesion | ECO:0000269 | PubMed:20489202 |
Cell junction, focal adhesion | ECO:0000269 | PubMed:23128389 |
Cell junction, focal adhesion | ECO:0000269 | PubMed:25015296 |
Cytoplasm, cell cortex | ECO:0000269 | |
Cytoplasm, cytoskeleton | ECO:0000269 | PubMed:20489202 |