Protein family
Protein sequence
Protein function
Publications
Catalytic activity
EC number
EC number description
1.2.1.19
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor;
aminobutyraldehyde dehydrogenase
1.2.1.3
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor;
aldehyde dehydrogenase (NAD+)
1.2.1.47
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor;
4-trimethylammoniobutyraldehyde dehydrogenase
| PDB | Resolution (Å) | PDB name |
|---|---|---|
| 6QAK | 2.5 | Structure of human ALDH9 in P21212 space group |
| 6QAO | 2.89 | Structure of human aldehyde dehydrogenase 9A1 in P21 space group |
| 6QAP | 2.3 | Structure of the human aldehyde dehydrogenase 9A1 in C2 space group |
| 6VR6 | 2.5 | Structure of ALDH9A1 complexed with NAD+ in space group P1 |
| 6VWF | 2.64 | Structure of ALDH9A1 complexed with NAD+ in space group C222 |
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0045329 | carnitine biosynthetic process |
| Biological Process | GO:0006081 | cellular aldehyde metabolic process |
| Biological Process | GO:0042445 | hormone metabolic process |
| Biological Process | GO:0042136 | neurotransmitter biosynthetic process |
| Biological Process | GO:0051289 | protein homotetramerization |
| Molecular Function | GO:0033737 | 1-pyrroline dehydrogenase activity |
| Molecular Function | GO:0047105 | 4-trimethylammoniobutyraldehyde dehydrogenase activity |
| Molecular Function | GO:0004029 | aldehyde dehydrogenase (NAD+) activity |
| Molecular Function | GO:0019145 | aminobutyraldehyde dehydrogenase activity |
| Molecular Function | GO:0043878 | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity |
| Molecular Function | GO:0036094 | small molecule binding |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| InterPro
|
InterPro name |
|---|---|
| IPR015590 | Aldehyde dehydrogenase domain |
| IPR016160 | Aldehyde dehydrogenase, cysteine active site |
| IPR016161 | Aldehyde/histidinol dehydrogenase |
| IPR016162 | Aldehyde dehydrogenase, N-terminal |
| IPR016163 | Aldehyde dehydrogenase, C-terminal |
| IPR029510 | Aldehyde dehydrogenase, glutamic acid active site |
| Pfam
|
Pfam name |
|---|---|
| PF00171 | Aldehyde dehydrogenase family |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-71262 | Carnitine synthesis | Leaf | R-HSA-1430728 | Metabolism |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Cytoplasm, cytosol | ECO:0000250 |
| HPO ID
|
HPO name |
|---|
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adipose tissue | adipocytes | High | Approved |
| adrenal gland | glandular cells | High | Approved |
| appendix | glandular cells | Medium | Approved |
| appendix | lymphoid tissue | Medium | Approved |
| bone marrow | hematopoietic cells | Medium | Approved |
| breast | adipocytes | Medium | Approved |
| breast | glandular cells | High | Approved |
| breast | myoepithelial cells | High | Approved |
| caudate | glial cells | Medium | Approved |
| caudate | neuronal cells | Low | Approved |
| cerebellum | Purkinje cells | Low | Approved |
| cerebellum | cells in granular layer | Low | Approved |
| cerebellum | cells in molecular layer | Medium | Approved |
| cerebral cortex | endothelial cells | High | Approved |
| cerebral cortex | glial cells | Medium | Approved |
| cerebral cortex | neuropil | Low | Approved |
| cervix | glandular cells | Low | Approved |
| cervix | squamous epithelial cells | Low | Approved |
| colon | endothelial cells | Low | Approved |
| colon | glandular cells | Medium | Approved |
| colon | peripheral nerve/ganglion | Low | Approved |
| duodenum | glandular cells | Medium | Approved |
| endometrium 1 | cells in endometrial stroma | Medium | Approved |
| endometrium 1 | glandular cells | Medium | Approved |
| endometrium 2 | cells in endometrial stroma | Medium | Approved |
| endometrium 2 | glandular cells | Medium | Approved |
| epididymis | glandular cells | High | Approved |
| esophagus | squamous epithelial cells | Medium | Approved |
| fallopian tube | glandular cells | Medium | Approved |
| gallbladder | glandular cells | Medium | Approved |
| heart muscle | cardiomyocytes | Low | Approved |
| hippocampus | glial cells | Medium | Approved |
| hippocampus | neuronal cells | Low | Approved |
| kidney | cells in glomeruli | Low | Approved |
| kidney | cells in tubules | Medium | Approved |
| liver | cholangiocytes | Medium | Approved |
| liver | hepatocytes | High | Approved |
| lung | alveolar cells | Medium | Approved |
| lung | macrophages | Medium | Approved |
| lymph node | germinal center cells | Medium | Approved |
| lymph node | non-germinal center cells | Medium | Approved |
| nasopharynx | respiratory epithelial cells | High | Approved |
| oral mucosa | squamous epithelial cells | Low | Approved |
| ovary | follicle cells | Medium | Approved |
| ovary | ovarian stroma cells | Medium | Approved |
| pancreas | exocrine glandular cells | Medium | Approved |
| pancreas | pancreatic endocrine cells | Low | Approved |
| parathyroid gland | glandular cells | High | Approved |
| placenta | trophoblastic cells | Low | Approved |
| prostate | glandular cells | Medium | Approved |
| rectum | glandular cells | Medium | Approved |
| salivary gland | glandular cells | Medium | Approved |
| seminal vesicle | glandular cells | Medium | Approved |
| skeletal muscle | myocytes | Medium | Approved |
| skin 1 | Langerhans | Medium | Approved |
| skin 1 | fibroblasts | Medium | Approved |
| skin 1 | keratinocytes | Medium | Approved |
| skin 1 | melanocytes | Medium | Approved |
| skin 2 | epidermal cells | Low | Approved |
| small intestine | glandular cells | Medium | Approved |
| smooth muscle | smooth muscle cells | Low | Approved |
| soft tissue 1 | fibroblasts | Medium | Approved |
| soft tissue 1 | peripheral nerve | Medium | Approved |
| soft tissue 2 | fibroblasts | Medium | Approved |
| soft tissue 2 | peripheral nerve | Medium | Approved |
| spleen | cells in red pulp | Medium | Approved |
| spleen | cells in white pulp | High | Approved |
| stomach 1 | glandular cells | Medium | Approved |
| stomach 2 | glandular cells | Medium | Approved |
| testis | Leydig cells | High | Approved |
| testis | cells in seminiferous ducts | High | Approved |
| thyroid gland | glandular cells | High | Approved |
| tonsil | germinal center cells | Medium | Approved |
| tonsil | non-germinal center cells | High | Approved |
| tonsil | squamous epithelial cells | High | Approved |
| urinary bladder | urothelial cells | Medium | Approved |
| vagina | squamous epithelial cells | Low | Approved |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|